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Cellosaurus SKBR-3-OE (CVCL_A2FE)

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Cell line name SKBR-3-OE
Accession CVCL_A2FE
Resource Identification Initiative To cite this cell line use: SKBR-3-OE (RRID:CVCL_A2FE)
Comments Population: Caucasian.
Characteristics: Using CRISPR/Cas9 a construct containing a CAG promoter-driven IGF2R gene was introduced in the AAVS1 safe harbor locus.
Genetic integration: Method=CRISPR/Cas9; Gene=HGNC; HGNC:5467; IGF2R.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; HGNC:1748; CDH1; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Homozygous (from parent cell line).
Disease Breast adenocarcinoma (NCIt: C5214)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0033 (SK-BR-3)
Sex of cell Female
Age at sampling 43Y
Category Cancer cell line
Publications

PubMed=33123265; DOI=10.3892/ol.2020.12216; PMCID=PMC7586281
Xin-Yu Ma, Ru Cao, Hai-Yan Xiao, Zhong-Wei Cao;
Establishment of a type II insulin-like growth factor receptor gene site-integrated SKBR3 cell line using CRISPR/Cas9.
Oncol. Lett. 20:354.1-354.9(2020)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A2FE
Encyclopedic resources Wikidata; Q105511095
Entry history
Entry creation12-Jan-2021
Last entry update19-Dec-2024
Version number7