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Cellosaurus SK-BR-3-LR (CVCL_4V52)

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Cell line name SK-BR-3-LR
Accession CVCL_4V52
Resource Identification Initiative To cite this cell line use: SK-BR-3-LR (RRID:CVCL_4V52)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_49603; Lapatinib (Tykerb; Tyverb).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; HGNC:1748; CDH1; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Homozygous (from parent cell line).
Disease Breast adenocarcinoma (NCIt: C5214)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0033 (SK-BR-3)
Sex of cell Female
Age at sampling 43Y
Category Cancer cell line
Publications

PubMed=23811285; DOI=10.1016/j.canlet.2013.06.022
Quan-Ren Wang, Hai-Tian Quan, Jie Zhao, Cheng-Ying Xie, Lei Wang, Li-Guang Lou;
RON confers lapatinib resistance in HER2-positive breast cancer cells.
Cancer Lett. 340:43-50(2013)

Cross-references
Cell line databases/resources cancercelllines; CVCL_4V52
Encyclopedic resources Wikidata; Q54953621
Entry history
Entry creation14-Dec-2015
Last entry update19-Dec-2024
Version number13