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Cellosaurus SKBR3-LR (CVCL_LG17)

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Cell line name SKBR3-LR
Accession CVCL_LG17
Resource Identification Initiative To cite this cell line use: SKBR3-LR (RRID:CVCL_LG17)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_49603; Lapatinib (Tykerb; Tyverb).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; HGNC:1748; CDH1; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Homozygous (from parent cell line).
Disease Breast adenocarcinoma (NCIt: C5214)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0033 (SK-BR-3)
Sex of cell Female
Age at sampling 43Y
Category Cancer cell line
Publications

PubMed=24876102; DOI=10.1158/0008-5472.CAN-13-2053
Sweta Rani, Claire Corcoran, Liam Shiels, Serena Germano, Susan Breslin, Stephen F. Madden, Martina S. McDermott, Brigid C. Browne, Norma O'Donovan, John Crown, Martina Gogarty ...Show all 13 authors... , Annette Therese Byrne, Lorraine O'Driscoll; Show fewer authors
Neuromedin U: a candidate biomarker and therapeutic target to predict and overcome resistance to HER-tyrosine kinase inhibitors.
Cancer Res. 74:3821-3833(2014)

Cross-references
Cell line databases/resources cancercelllines; CVCL_LG17
Encyclopedic resources Wikidata; Q54954672
Entry history
Entry creation15-Nov-2017
Last entry update19-Dec-2024
Version number11