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Cellosaurus SK-BR-3/PacR (CVCL_B7P8)

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Cell line name SK-BR-3/PacR
Accession CVCL_B7P8
Resource Identification Initiative To cite this cell line use: SK-BR-3/PacR (RRID:CVCL_B7P8)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_45863; Paclitaxel (Taxol).
Miscellaneous: Cell line no longer available (personal communication of Daniel, Petr).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; HGNC:1748; CDH1; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Homozygous (from parent cell line).
Disease Breast adenocarcinoma (NCIt: C5214)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0033 (SK-BR-3)
Sex of cell Female
Age at sampling 43Y
Category Cancer cell line
Publications

PubMed=27664577; DOI=10.1016/j.taap.2016.09.020
Vlasta Nemcova-Furstova, Dana Kopperova, Kamila Balusikova, Marie Ehrlichova, Veronika Brynychova, Radka Vaclavikova, Petr Daniel, Pavel Soucek, Jan Kovar;
Characterization of acquired paclitaxel resistance of breast cancer cells and involvement of ABC transporters.
Toxicol. Appl. Pharmacol. 310:215-228(2016)

PubMed=29625142; DOI=10.1016/j.taap.2018.04.002; PMCID=PMC5937276
Michael Jelinek, Kamila Balusikova, Petr Daniel, Vlasta Nemcova-Furstova, Palani Kirubakaran, Martin Jacek, Long-Fei Wei, Xin Wang, Jiri Vondrasek, Iwao Ojima, Jan Kovar;
Substituents at the C3' and C3'N positions are critical for taxanes to overcome acquired resistance of cancer cells to paclitaxel.
Toxicol. Appl. Pharmacol. 347:79-91(2018)

Cross-references
Cell line databases/resources cancercelllines; CVCL_B7P8
Encyclopedic resources Wikidata; Q112930399
Entry history
Entry creation23-Jun-2022
Last entry update19-Dec-2024
Version number7