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Cellosaurus SK-BR-3/PacR (CVCL_B7P8)

[Text version]
Cell line name SK-BR-3/PacR
Accession CVCL_B7P8
Resource Identification Initiative To cite this cell line use: SK-BR-3/PacR (RRID:CVCL_B7P8)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:45863; Paclitaxel (Taxol).
Miscellaneous: Cell line no longer available (personal communication of Daniel P.).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; 1748; CDH1; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Homozygous (from parent cell line).
Disease Breast adenocarcinoma (NCIt: C5214)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0033 (SK-BR-3)
Sex of cell Female
Age at sampling 43Y
Category Cancer cell line

PubMed=27664577; DOI=10.1016/j.taap.2016.09.020
Nemcova-Furstova V., Kopperova D., Balusikova K., Ehrlichova M., Brynychova V., Vaclavikova R., Daniel P., Soucek P., Kovar J.
Characterization of acquired paclitaxel resistance of breast cancer cells and involvement of ABC transporters.
Toxicol. Appl. Pharmacol. 310:215-228(2016)

PubMed=29625142; DOI=10.1016/j.taap.2018.04.002
Jelinek M., Balusikova K., Daniel P., Nemcova-Furstova V., Kirubakaran P., Jacek M., Wei L.-F., Wang X., Vondrasek J., Ojima I., Kovar J.
Substituents at the C3' and C3'N positions are critical for taxanes to overcome acquired resistance of cancer cells to paclitaxel.
Toxicol. Appl. Pharmacol. 347:79-91(2018)

Cell line databases/resources cancercelllines; CVCL_B7P8
Encyclopedic resources Wikidata; Q112930399
Entry history
Entry creation23-Jun-2022
Last entry update05-Oct-2023
Version number5