Cellosaurus logo
expasy logo

Cellosaurus SKBR3-AZDRb (CVCL_EI05)

[Text][XML][JSON]
Cell line name SKBR3-AZDRb
Accession CVCL_EI05
Resource Identification Initiative To cite this cell line use: SKBR3-AZDRb (RRID:CVCL_EI05)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_132986; Sapitinib (AZD8931).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; HGNC:1748; CDH1; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Homozygous (from parent cell line).
Disease Breast adenocarcinoma (NCIt: C5214)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0033 (SK-BR-3)
Sex of cell Female
Age at sampling 43Y
Category Cancer cell line
Publications

PubMed=26883193; DOI=10.18632/oncotarget.7317; PMCID=PMC4905492
Helen Creedon, Laura Gomez-Cuadrado, Zygimante Tarnauskaite, Jozef Balla, Marta Canel, Kenneth G. MacLeod, Bryan Serrels, Craig Fraser, Asier Unciti-Broceta, Natasha Tracey, Thierry Le Bihan ...Show all 15 authors... , Teresa Klinowska, Andrew H. Sims, Adam Byron, Valerie G. Brunton; Show fewer authors
Identification of novel pathways linking epithelial-to-mesenchymal transition with resistance to HER2-targeted therapy.
Oncotarget 7:11539-11552(2016)

Cross-references
Cell line databases/resources cancercelllines; CVCL_EI05
Encyclopedic resources Wikidata; Q54954665
Entry history
Entry creation13-Jul-2016
Last entry update19-Dec-2024
Version number12