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Cellosaurus SKBR3-NR (CVCL_LG18)

[Text version]
Cell line name SKBR3-NR
Accession CVCL_LG18
Resource Identification Initiative To cite this cell line use: SKBR3-NR (RRID:CVCL_LG18)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:61397; Neratinib (Nerlynx; HKI-272).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; 1748; CDH1; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Homozygous (from parent cell line).
Disease Breast adenocarcinoma (NCIt: C5214)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0033 (SK-BR-3)
Sex of cell Female
Age at sampling 43Y
Category Cancer cell line

PubMed=24876102; DOI=10.1158/0008-5472.CAN-13-2053
Rani S., Corcoran C., Shiels L., Germano S., Breslin S., Madden S.F., McDermott M.S., Browne B.C., O'Donovan N., Crown J., Gogarty M., Byrne A.T., O'Driscoll L.
Neuromedin U: a candidate biomarker and therapeutic target to predict and overcome resistance to HER-tyrosine kinase inhibitors.
Cancer Res. 74:3821-3833(2014)

Cell line databases/resources cancercelllines; CVCL_LG18
Encyclopedic resources Wikidata; Q54954674
Entry history
Entry creation15-Nov-2017
Last entry update05-Oct-2023
Version number10