Cellosaurus cell line hTERT-RPE1 (CVCL

Cellosaurus hTERT-RPE1 (CVCL_4388)

[Text version]

Cell line name

hTERT-RPE1

Synonyms

hTERT RPE1; hTERT-RPE-1; hTERT RPE-1; hTERT-RPE; TERT-RPE1; RPE-1; RPE1; RPE1-hTERT; RPE1-hTert; RPE-hTERT

Accession

CVCL_4388

Resource Identification Initiative

To cite this cell line use: hTERT-RPE1 (RRID:CVCL_4388)

Comments

Transfected with: HGNC; 11730; TERT.
Transfected with: UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph).
Omics: Deep proteome analysis.
Omics: Transcriptome analysis by RNAseq.
Misspelling: hTERT1-RPE1; Note=Occasionally.
Derived from site: In situ; Eye, retina, retinal pigment epithelium; UBERON=UBERON_0001782.
Cell type: Retinal pigment epithelial cell; CL=CL_0002586.

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Parent: CVCL_B365 (RPE-340)
Children:

CVCL_VP32 (hTERT-RPE1 FRT/TR)	CVCL_C1AM (RPE1_APC_836)	CVCL_C1AN (RPE1_APC_845)
CVCL_C1AP (RPE1_ARID1A_1.C7)	CVCL_C1AQ (RPE1_ARID1A_D5)	CVCL_C1AR (RPE1_ATM_303)
CVCL_C1AS (RPE1_ATM_306)	CVCL_C1AT (RPE1_CDKN2A_7)	CVCL_C1AU (RPE1_CDKN2C_241)
CVCL_C1AV (RPE1_CDKN2C_242)	CVCL_C1AW (RPE1_EZH2_2)	CVCL_C1AX (RPE1_EZH2_A1)
CVCL_C1AY (RPE1_EZH2_A4)	CVCL_C1CL (RPE1_HPRT1_E10)	CVCL_C1AZ (RPE1_MLL2_8)
CVCL_C1B0 (RPE1_MSH2_393)	CVCL_C1B1 (RPE1_MSH2_394)	CVCL_C1B2 (RPE1_MSH2_405)
CVCL_C1B3 (RPE1_MSH6_266)	CVCL_C1B4 (RPE1_MSH6_269)	CVCL_C1B5 (RPE1_MSH6_271)
CVCL_C1CG (RPE1_MTAP_5)	CVCL_C1CH (RPE1_MTAP_6)	CVCL_C1CI (RPE1_MTAP_7)
CVCL_C1B6 (RPE1_NOTCH1_2)	CVCL_C1B7 (RPE1_NOTCH1_B6)	CVCL_C1B8 (RPE1_NOTCH1_C2)
CVCL_C1B9 (RPE1_PTCH1_3)	CVCL_C1BA (RPE1_PTCH1_6)	CVCL_C1BB (RPE1_PTEN_2)
CVCL_C1BC (RPE1_PTEN_8)	CVCL_C1BD (RPE1_STAG2_2)	CVCL_C1BE (RPE1_STAG2_5)
CVCL_C1BF (RPE1_STAG2_8)	CVCL_C1BG (RPE1_TET2_C9)	CVCL_C1BH (RPE1_TET2_D2)
CVCL_C1BI (RPE1_TET2_E7)	CVCL_C1BJ (RPE1_TP53_219)	CVCL_C1BK (RPE1_TP53_221)
CVCL_C1BL (RPE1_TP53_224)	CVCL_C8DM (RPE1-SS111)	CVCL_C8DN (RPE1-SS119)
CVCL_C8DP (RPE1-SS31)	CVCL_C8DQ (RPE1-SS48)	CVCL_C8DR (RPE1-SS51)
CVCL_C8DS (RPE1-SS6)	CVCL_C8DT (RPE1-SS77)

Sex of cell

Female

Age at sampling

Category

Telomerase immortalized cell line

STR profile

Source(s): ATCC; PubMed=25877200

Markers:

Amelogenin	X
CSF1PO	12,14
D3S1358	15,16
D5S818	11
D7S820	10,11
D8S1179	10
D13S317	11,12
D16S539	11
D18S51	14,16
D21S11	31,32.2
FGA	20,23
Penta D	9,11
Penta E	12,14
TH01	9
TPOX	8
vWA	17,18

Web pages

http://www.cellimagelibrary.org/images/35201
http://www.immanis.com/TelomeraseImmortalizedCellLineCulturingGuide.pdf

Publications

PubMed=9454332; DOI=10.1126/science.279.5349.349
Bodnar A.G., Ouellette M.M., Frolkis M., Holt S.E., Chiu C.-P., Morin G.B., Harley C.B., Shay J.W., Lichtsteiner S., Wright W.E.
Extension of life-span by introduction of telomerase into normal human cells.
Science 279:349-352(1998)

PubMed=11980883
Rambhatla L., Chiu C.-P., Glickman R.D., Rowe-Rendleman C.
In vitro differentiation capacity of telomerase immortalized human RPE cells.
Invest. Ophthalmol. Vis. Sci. 43:1622-1630(2002)

PubMed=25177495; DOI=10.1155/2014/801787
Kuznetsova A.V., Kurinov A.M., Aleksandrova M.A.
Cell models to study regulation of cell transformation in pathologies of retinal pigment epithelium.
J. Ophthalmol. 2014:801787.1-801787.18(2014)

PubMed=28350380; DOI=10.1038/sdata.2017.33
Harenza J.L., Diamond M.A., Adams R.N., Song M.M., Davidson H.L., Hart L.S., Dent M.H., Fortina P., Reynolds C.P., Maris J.M.
Transcriptomic profiling of 39 commonly-used neuroblastoma cell lines.
Sci. Data 4:170033-170033(2017)

Cross-references

Cell line collections (Providers)

ATCC; CRL-4000

Cell line databases/resources

Cell_Model_Passport; SIDM00409

Anatomy/cell type resources

BTO; BTO:0004790

Biological sample resources

4DN; 4DNSRHGVFSRJ
BioSample; SAMN03472089

Chemistry resources

ChEMBL-Cells; CHEMBL3307755
ChEMBL-Targets; CHEMBL615013
PubChem_Cell_line; CVCL_4388

Encyclopedic resources