Cellosaurus logo
expasy logo

Cellosaurus hTERT-RPE1 (CVCL_4388)

[Text version]
Cell line name hTERT-RPE1
Synonyms hTERT RPE1; hTERT-RPE-1; hTERT RPE-1; hTERT-RPE; TERT-RPE1; RPE-1; RPE1; RPE1-hTERT; RPE1-hTert; RPE-hTERT
Accession CVCL_4388
Resource Identification Initiative To cite this cell line use: hTERT-RPE1 (RRID:CVCL_4388)
Comments Genetic integration: Method=Transfection; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Omics: Phenotyping; CRISPR screening.
Omics: Proteomics.
Omics: Transcriptomics; RNAseq.
Misspelling: hTERT1-RPE1; Note=Occasionally.
Derived from site: In situ; Eye, retina, retinal pigment epithelium; UBERON=UBERON_0001782.
Cell type: Retinal pigment epithelial cell; CL=CL_0002586.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_B365 (RPE-340)
Children:
CVCL_VP32 (hTERT-RPE1 FRT/TR)CVCL_E3VG (hTERT-RPE1 PBRM1 KO 1)CVCL_E3VH (hTERT-RPE1 PBRM1 KO 2)
CVCL_E3VI (hTERT-RPE1 PBRM1 KO 3)CVCL_E3WG (hTERT-RPE1 SMARCA4 KO 1C9)CVCL_E3WH (hTERT-RPE1 SMARCA4 KO 1D2)
CVCL_E3WI (hTERT-RPE1 SMARCA4 KO 1H1)CVCL_E3WJ (hTERT-RPE1 SMARCA4 KO 2BS)CVCL_E3WK (hTERT-RPE1 SMARCA4 KO TH12)
CVCL_C1AM (RPE1_APC_836)CVCL_C1AN (RPE1_APC_845)CVCL_C1AP (RPE1_ARID1A_1.C7)
CVCL_C1AQ (RPE1_ARID1A_D5)CVCL_C1AR (RPE1_ATM_303)CVCL_C1AS (RPE1_ATM_306)
CVCL_C1AT (RPE1_CDKN2A_7)CVCL_C1AU (RPE1_CDKN2C_241)CVCL_C1AV (RPE1_CDKN2C_242)
CVCL_C1AW (RPE1_EZH2_2)CVCL_C1AX (RPE1_EZH2_A1)CVCL_C1AY (RPE1_EZH2_A4)
CVCL_C1CL (RPE1_HPRT1_E10)CVCL_C1AZ (RPE1_MLL2_8)CVCL_C1B0 (RPE1_MSH2_393)
CVCL_C1B1 (RPE1_MSH2_394)CVCL_C1B2 (RPE1_MSH2_405)CVCL_C1B3 (RPE1_MSH6_266)
CVCL_C1B4 (RPE1_MSH6_269)CVCL_C1B5 (RPE1_MSH6_271)CVCL_C1CG (RPE1_MTAP_5)
CVCL_C1CH (RPE1_MTAP_6)CVCL_C1CI (RPE1_MTAP_7)CVCL_C1B6 (RPE1_NOTCH1_2)
CVCL_C1B7 (RPE1_NOTCH1_B6)CVCL_C1B8 (RPE1_NOTCH1_C2)CVCL_C1B9 (RPE1_PTCH1_3)
CVCL_C1BA (RPE1_PTCH1_6)CVCL_C1BB (RPE1_PTEN_2)CVCL_C1BC (RPE1_PTEN_8)
CVCL_C1BD (RPE1_STAG2_2)CVCL_C1BE (RPE1_STAG2_5)CVCL_C1BF (RPE1_STAG2_8)
CVCL_C1BG (RPE1_TET2_C9)CVCL_C1BH (RPE1_TET2_D2)CVCL_C1BI (RPE1_TET2_E7)
CVCL_C1BJ (RPE1_TP53_219)CVCL_C1BK (RPE1_TP53_221)CVCL_C1BL (RPE1_TP53_224)
CVCL_C8DM (RPE1-SS111)CVCL_C8DN (RPE1-SS119)CVCL_C8DP (RPE1-SS31)
CVCL_C8DQ (RPE1-SS48)CVCL_C8DR (RPE1-SS51)CVCL_C8DS (RPE1-SS6)
CVCL_C8DT (RPE1-SS77)
Sex of cell Female
Age at sampling 1Y
Category Telomerase immortalized cell line
STR profile Source(s): ATCC=CRL-4000; PubMed=25877200

Markers:
AmelogeninX
CSF1PO12,14
D2S133819,24
D3S135815,16
D5S81811
D7S82010,11
D8S117910
D13S31711,12
D16S53911
D18S5114,16
D19S43314,16.2
D21S1131,32.2
FGA20,23
Penta D9,11
Penta E12,14
TH019
TPOX8
vWA17,18

Run an STR similarity search on this cell line
Web pages Info; CIL; 35201; https://www.cellimagelibrary.org/images/35201
Info; HPA; -; https://www.proteinatlas.org/learn/cellines
Publications

PubMed=9454332; DOI=10.1126/science.279.5349.349
Bodnar A.G., Ouellette M.M., Frolkis M., Holt S.E., Chiu C.-P., Morin G.B., Harley C.B., Shay J.W., Lichtsteiner S.P., Wright W.E.
Extension of life-span by introduction of telomerase into normal human cells.
Science 279:349-352(1998)

PubMed=11980883
Rambhatla L., Chiu C.-P., Glickman R.D., Rowe-Rendleman C.
In vitro differentiation capacity of telomerase immortalized human RPE cells.
Invest. Ophthalmol. Vis. Sci. 43:1622-1630(2002)

PubMed=25177495; DOI=10.1155/2014/801787; PMCID=PMC4142280
Kuznetsova A.V., Kurinov A.M., Aleksandrova M.A.
Cell models to study regulation of cell transformation in pathologies of retinal pigment epithelium.
J. Ophthalmol. 2014:801787.1-801787.18(2014)

PubMed=25877200; DOI=10.1038/nature14397
Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S., Neve R.M.
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=28350380; DOI=10.1038/sdata.2017.33; PMCID=PMC5369315
Harenza J.L., Diamond M.A., Adams R.N., Song M.M., Davidson H.L., Hart L.S., Dent M.H., Fortina P., Reynolds C.P., Maris J.M.
Transcriptomic profiling of 39 commonly-used neuroblastoma cell lines.
Sci. Data 4:170033.1-170033.8(2017)

PubMed=30971826; DOI=10.1038/s41586-019-1103-9
Behan F.M., Iorio F., Picco G., Goncalves E., Beaver C.M., Migliardi G., Santos R., Rao Y., Sassi F., Pinnelli M., Ansari R., Harper S., Jackson D.A., McRae R., Pooley R., Wilkinson P., van der Meer D.J., Dow D., Buser-Doepner C.A., Bertotti A., Trusolino L., Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Nature 568:511-516(2019)

Cross-references
Cell line collections (Providers) ATCC; CRL-4000
Cell line databases/resources Cell_Model_Passport; SIDM00409
Anatomy/cell type resources BTO; BTO_0004790
Biological sample resources 4DN; 4DNSRHGVFSRJ
BioSample; SAMN03472089
CRISP screens repositories BioGRID_ORCS_Cell_line; 157
Chemistry resources ChEMBL-Cells; CHEMBL3307755
ChEMBL-Targets; CHEMBL615013
PubChem_Cell_line; CVCL_4388
Encyclopedic resources Wikidata; Q54896633
Experimental variables resources EFO; EFO_0022539
Gene expression databases GEO; GSM2371252
GEO; GSM7701393
GEO; GSM7701394
Proteomic databases PRIDE; PXD004915
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number29