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Cellosaurus RPE1-SS6 (CVCL_C8DS)

[Text version]
Cell line name RPE1-SS6
Synonyms RPE1SS6
Accession CVCL_C8DS
Resource Identification Initiative To cite this cell line use: RPE1-SS6 (RRID:CVCL_C8DS)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Characteristics: This cell line has a stable aneuploid karyotype, the parent cell line was transiently treated with the TTK inhibitor reversine to induce random chromosome gains and losses (PubMed=33505028).
Karyotypic information: Contains an extra Chr 7 (PubMed=33505028).
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Derived from site: In situ; Eye, retina, retinal pigment epithelium; UBERON=UBERON_0001782.
Cell type: Retinal pigment epithelial cell; CL=CL_0002586.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_4388 (hTERT-RPE1)
Sex of cell Female
Age at sampling 1Y
Category Telomerase immortalized cell line
Publications

PubMed=33505028; DOI=10.1038/s41586-020-03114-6; PMCID=PMC8262644
Cohen-Sharir Y., McFarland J.M., Abdusamad M., Marquis C., Bernhard S.V., Kazachkova M., Tang H., Ippolito M.R., Laue K., Zerbib J., Malaby H.L.H., Jones A., Stautmeister L.-M., Bockaj I., Wardenaar R., Lyons N., Nagaraja A.K., Bass A.J., Spierings D.C.J., Foijer F., Beroukhim R., Santaguida S., Golub T.R., Stumpff J., Storchova Z., Ben-David U.
Aneuploidy renders cancer cells vulnerable to mitotic checkpoint inhibition.
Nature 590:486-491(2021)

Cross-references
Cell line databases/resources DepMap; ACH-002464
Encyclopedic resources Wikidata; Q123033375
Entry history
Entry creation29-Jun-2023
Last entry update19-Dec-2024
Version number5