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Cellosaurus RPE1-SS6 (CVCL_C8DS)

[Text version]
Cell line name RPE1-SS6
Synonyms RPE1SS6
Accession CVCL_C8DS
Resource Identification Initiative To cite this cell line use: RPE1-SS6 (RRID:CVCL_C8DS)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Characteristics: This cell line has a stable aneuploid karyotype, the parent cell line was transiently treated with the TTK inhibitor reversine to induce random chromosome gains and losses (PubMed=33505028).
Karyotypic information: Contains an extra Chr 7 (PubMed=33505028).
Transfected with: HGNC; 11730; TERT.
Transfected with: UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Derived from site: In situ; Eye, retina, retinal pigment epithelium; UBERON=UBERON_0001782.
Cell type: Retinal pigment epithelial cell; CL=CL_0002586.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_4388 (hTERT-RPE1)
Sex of cell Female
Age at sampling 1Y
Category Telomerase immortalized cell line

PubMed=33505028; DOI=10.1038/s41586-020-03114-6
Cohen-Sharir Y., McFarland J.M., Abdusamad M., Marquis C., Bernhard S.V., Kazachkova M., Tang H., Ippolito M.R., Laue K., Zerbib J., Malaby H.L.H., Jones A., Stautmeister L.M., Bockaj I., Wardenaar R., Lyons N., Nagaraja A.K., Bass A.J., Spierings D.C.J., Foijer F., Beroukhim R., Santaguida S., Golub T.R., Stumpff J., Storchova Z., Ben-David U.
Aneuploidy renders cancer cells vulnerable to mitotic checkpoint inhibition.
Nature 590:486-491(2021)

Cell line databases/resources DepMap; ACH-002464
Entry history
Entry creation29-Jun-2023
Last entry update05-Oct-2023
Version number2