Cellosaurus cell line RPE1-SS77 (CVCL

Cellosaurus RPE1-SS77 (CVCL_C8DT)

Cross-references
Cell line name	RPE1-SS77
Synonyms	RPE1SS77
Accession	CVCL_C8DT
Resource Identification Initiative	To cite this cell line use: RPE1-SS77 (RRID:CVCL_C8DT)
Comments	Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). Characteristics: Control cell line for a set of aneuploid derivatives (PubMed=33505028). Genetic integration: Method=Transfection; Gene=HGNC; HGNC:11730; TERT. Genetic integration: Method=Transfection; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR). Derived from site: In situ; Eye, retina, retinal pigment epithelium; UBERON=UBERON_0001782. Cell type: Retinal pigment epithelial cell; CL=CL_0002586.
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_4388 (hTERT-RPE1)
Sex of cell	Female
Age at sampling	1Y
Category	Telomerase immortalized cell line
Publications	PubMed=33505028; DOI=10.1038/s41586-020-03114-6; PMCID=PMC8262644 Yael Cohen-Sharir, James M. McFarland, Mai Abdusamad, Carolyn Marquis, Sara V. Bernhard, Mariya Kazachkova, Helen Tang, Marica Rssaria Ippolito, Kathrin Laue, Johanna Zerbib, Heidi L.H. Malaby ...Show all 26 authors... , Andrew Jones, Lisa-Marie Stautmeister, Irena Bockaj, Rene Wardenaar, Nicholas Lyons, Ankur K. Nagaraja, Adam J. Bass, Diana C.J. Spierings, Floris Foijer, Rameen Beroukhim, Stefano Santaguida, Todd Robert Golub, Jason Stumpff, Zuzana Storchova, Uri Ben-David; Show fewer authors Aneuploidy renders cancer cells vulnerable to mitotic checkpoint inhibition. Nature 590:486-491(2021)
Cell line databases/resources	DepMap; ACH-002463
Encyclopedic resources	Wikidata; Q123033376
Entry history
Entry creation	29-Jun-2023
Last entry update	19-Dec-2024
Version number	5