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Cellosaurus hTERT-RPE1 PBRM1 KO 2 (CVCL_E3VH)

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Cell line name hTERT-RPE1 PBRM1 KO 2
Synonyms RPE1 PBRM1 KO2; hTERT-RPE1 knockout for PBRM1 clone 2; hTERT-RPE1 knockout for PBRM1 clone B16
Accession CVCL_E3VH
Resource Identification Initiative To cite this cell line use: hTERT-RPE1 PBRM1 KO 2 (RRID:CVCL_E3VH)
Comments Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:30064; PBRM1.
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Derived from site: In situ; Eye, retina, retinal pigment epithelium; UBERON=UBERON_0001782.
Cell type: Retinal pigment epithelial cell; CL=CL_0002586.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_4388 (hTERT-RPE1)
Sex of cell Female
Age at sampling 1Y
Category Telomerase immortalized cell line
Publications

PubMed=35902118; DOI=10.1101/gad.349249.121; PMCID=PMC9480851
Feng H.-G., Lane K.A., Roumeliotis T.I., Jeggo P.A., Somaiah N., Choudhary J.S., Downs J.A.
PBAF loss leads to DNA damage-induced inflammatory signaling through defective G2/M checkpoint maintenance.
Genes Dev. 36:790-806(2022)

Cross-references
Cell line collections (Providers) CancerTools; 161857
Entry history
Entry creation19-Dec-2024
Last entry update19-Dec-2024
Version number1