AC   CVCL_4388
DR   BTO; BTO:0004790
DR   ATCC; CRL-4000
DR   BioSample; SAMN03472089
DR   Cell_Model_Passport; SIDM00409
DR   ChEMBL-Cells; CHEMBL3307755
DR   ChEMBL-Targets; CHEMBL615013
DR   GEO; GSM2371252
DR   PRIDE; PXD004915
DR   PubChem_Cell_line; CVCL_4388
DR   Wikidata; Q54896633
RX   PubMed=9454332;
RX   PubMed=11980883;
RX   PubMed=25177495;
RX   PubMed=25877200;
RX   PubMed=28350380;
RX   PubMed=30971826;
CC   Transfected with: HGNC; 11730; TERT.
CC   Transfected with: UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
CC   Omics: CRISPR phenotypic screen.
CC   Omics: Deep proteome analysis.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Misspelling: hTERT1-RPE1; Note=Occasionally.
CC   Derived from site: In situ; Eye, retina, retinal pigment epithelium; UBERON=UBERON_0001782.
CC   Cell type: Retinal pigment epithelial cell; CL=CL_0002586.
ST   Source(s): ATCC; PubMed=25877200
ST   Amelogenin: X
ST   CSF1PO: 12,14
ST   D13S317: 11,12
ST   D16S539: 11
ST   D18S51: 14,16
ST   D21S11: 31,32.2
ST   D3S1358: 15,16
ST   D5S818: 11
ST   D7S820: 10,11
ST   D8S1179: 10
ST   FGA: 20,23
ST   Penta D: 9,11
ST   Penta E: 12,14
ST   TH01: 9
ST   TPOX: 8
ST   vWA: 17,18
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_B365 ! RPE-340
SX   Female
AG   1Y
CA   Telomerase immortalized cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 24
RX   PubMed=9454332; DOI=10.1126/science.279.5349.349;
RA   Bodnar A.G., Ouellette M.M., Frolkis M., Holt S.E., Chiu C.-P.,
RA   Morin G.B., Harley C.B., Shay J.W., Lichtsteiner S.P., Wright W.E.;
RT   "Extension of life-span by introduction of telomerase into normal
RT   human cells.";
RL   Science 279:349-352(1998).
RX   PubMed=11980883;
RA   Rambhatla L., Chiu C.-P., Glickman R.D., Rowe-Rendleman C.;
RT   "In vitro differentiation capacity of telomerase immortalized human
RT   RPE cells.";
RL   Invest. Ophthalmol. Vis. Sci. 43:1622-1630(2002).
RX   PubMed=25177495; DOI=10.1155/2014/801787;
RA   Kuznetsova A.V., Kurinov A.M., Aleksandrova M.A.;
RT   "Cell models to study regulation of cell transformation in pathologies
RT   of retinal pigment epithelium.";
RL   J. Ophthalmol. 2014:801787.1-801787.18(2014).
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M.,
RA   Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S.,
RA   Neve R.M.;
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
RX   PubMed=28350380; DOI=10.1038/sdata.2017.33;
RA   Harenza J.L., Diamond M.A., Adams R.N., Song M.M., Davidson H.L.,
RA   Hart L.S., Dent M.H., Fortina P., Reynolds C.P., Maris J.M.;
RT   "Transcriptomic profiling of 39 commonly-used neuroblastoma cell
RT   lines.";
RL   Sci. Data 4:170033-170033(2017).
RX   PubMed=30971826; DOI=10.1038/s41586-019-1103-9;
RA   Behan F.M., Iorio F., Picco G., Goncalves E., Beaver C.M.,
RA   Migliardi G., Santos R., Rao Y., Sassi F., Pinnelli M., Ansari R.,
RA   Harper S., Jackson D.A., McRae R., Pooley R., Wilkinson P.,
RA   van der Meer D.J., Dow D., Buser-Doepner C.A., Bertotti A., Trusolino L.,
RA   Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.;
RT   "Prioritization of cancer therapeutic targets using CRISPR-Cas9
RT   screens.";
RL   Nature 568:511-516(2019).