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Cellosaurus RPE1_PTEN_2 (CVCL_C1BB)

[Text version]
Cell line name RPE1_PTEN_2
Accession CVCL_C1BB
Resource Identification Initiative To cite this cell line use: RPE1_PTEN_2 (RRID:CVCL_C1BB)
Comments Part of: Cancer Pathway Knockout Panel.
Knockout cell: Method=CRISPR/Cas9; HGNC; 9588; PTEN.
Transfected with: HGNC; 11730; TERT.
Transfected with: UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph).
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Eye, retina, retinal pigment epithelium; UBERON=UBERON_0001782.
Cell type: Retinal pigment epithelial cell; CL=CL_0002586.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_4388 (hTERT-RPE1)
Sex of cell Female
Age at sampling 1Y
Category Telomerase immortalized cell line
Publications

PubMed=35692635; DOI=10.1016/j.isci.2022.104437
Cook A.L., Wyhs N., Sur S., Ptak B., Popoli M., Dobbyn L., Papadopoulos T., Bettegowda C., Papadopoulos N., Vogelstein B., Zhou S., Kinzler K.W.
An isogenic cell line panel for sequence-based screening of targeted anticancer drugs.
IScience 25:104437.1-104437.14(2022)

Cross-references
Encyclopedic resources Wikidata; Q114312857
Sequence databases EGA; EGAD00001008559
Entry history
Entry creation22-Sep-2022
Last entry update29-Jun-2023
Version number4