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Cellosaurus RPE1_PTEN_2 (CVCL_C1BB)

[Text version]
Cell line name RPE1_PTEN_2
Accession CVCL_C1BB
Resource Identification Initiative To cite this cell line use: RPE1_PTEN_2 (RRID:CVCL_C1BB)
Comments Part of: Cancer Pathway Knockout Panel.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:9588; PTEN.
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Eye, retina, retinal pigment epithelium; UBERON=UBERON_0001782.
Cell type: Retinal pigment epithelial cell; CL=CL_0002586.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_4388 (hTERT-RPE1)
Sex of cell Female
Age at sampling 1Y
Category Telomerase immortalized cell line
Publications

PubMed=35692635; DOI=10.1016/j.isci.2022.104437; PMCID=PMC9184558
Cook A.L., Wyhs N., Sur S., Ptak B., Popoli M., Dobbyn L., Papadopoulos T., Bettegowda C., Papadopoulos N., Vogelstein B., Zhou S.-B., Kinzler K.W.
An isogenic cell line panel for sequence-based screening of targeted anticancer drugs.
iScience 25:104437.1-104437.13(2022)

Cross-references
Encyclopedic resources Wikidata; Q114312857
Sequence databases EGA; EGAD00001008559
Entry history
Entry creation22-Sep-2022
Last entry update10-Apr-2025
Version number8