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Cellosaurus U-937 (CVCL_0007)

[Text version]
Cell line name U-937
Synonyms U937; U 937
Accession CVCL_0007
Resource Identification Initiative To cite this cell line use: U-937 (RRID:CVCL_0007)
Comments Group: Space-flown cell line (cellonaut).
Problematic cell line: Partially contaminated. Some ATCC stocks were cross-contaminated by K-562 initially (PubMed=7759961). The problem was corrected and subsequent stocks have been confirmed to carry only U-937.
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: Human Protein Atlas, Cell Atlas panel.
Part of: LL-100 blood cancer cell line panel.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00168.
Population: Caucasian.
Characteristics: Can be induced to differentiate into macrophages by several factors such as phorbol ester (PMA) and 12-O-tetradecanoyl-13-phorbol acetate (TPA).
Doubling time: 95-100 hours (PubMed=178611); ~30-40 hours (DSMZ=ACC-5).
Karyotypic information: Has lost chromosome Y.
Microsatellite instability: Stable (MSS) (PubMed=10739008; PubMed=11226526).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Proteomics.
Omics: Proteomics; 2DE-MS.
Omics: Proteomics; Expression; Large antibody panel staining analysis.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Anecdotal: Have been flown in space on shuttle flight STS-76 and on Shenzhou-8 to study growth and cytoskeletal changes in microgravity (PubMed=10352142; DOI=10.1016/j.actaastro.2013.06.007).
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; HGNC:16063; MLLT10 + HGNC; HGNC:15514; PICALM; Name(s)=PICALM-MLLT10, CALM-AF10 (PubMed=8643484; PubMed=25485619).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Gly129fs*51 (c.387_388insCGCC); Zygosity=Hemizygous (PubMed=10966170; DepMap=ACH-000406).
  • Mutation; HGNC; HGNC:9644; PTPN11; Simple; p.Gly60Arg (c.178G>C); ClinVar=VCV000372590; Zygosity=Heterozygous (DepMap=ACH-000406).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; c.559+1G>A (p.Val173Trpfs*59); ClinVar=VCV000428908; Zygosity=Homozygous; Note=Splice donor mutation (PubMed=1571549; DepMap=ACH-000406).
  • Mutation; HGNC; HGNC:12796; WT1; Simple; p.Arg301Ter (c.901C>T) (p.Arg352Ter, c.1054C>T) (p.Arg374Ter, c.1120C>T); ClinVar=VCV000449416; Zygosity=Heterozygous (DepMap=ACH-000406).
HLA typing Source: IPD-IMGT/HLA=11507
Class II
HLA-DRDRB1*16:01

Source: PubMed=26589293
Class I
HLA-AA*03:01,03:01
HLA-BB*18:01,51:01
HLA-CC*01:02,07:01
Class II
HLA-DRDRB1*16:01,16:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0
East Asian, North2.39
East Asian, South0
South Asian0
European, North71.54
European, South26.06
Disease Adult acute monocytic leukemia (NCIt: C8263)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_3680 (EL 1)CVCL_E1N8 (HyCyte U-937 KO-hPTPRA)CVCL_E7RW (iLite Type I IFN Assay Ready Cells)
CVCL_2082 (JOSK-I)CVCL_8141 (JOSK-K)CVCL_2083 (JOSK-M)
CVCL_8142 (JOSK-S)CVCL_B3XU (MBU-7)CVCL_B3XV (MBU-8)
CVCL_8442 (MOBS-1)CVCL_L107 (PH [Human])CVCL_9997 (SAML-1)
CVCL_6444 (SC [Human contaminated U-937])CVCL_1775 (TUR)CVCL_2810 (U-937 cl1-14)
CVCL_2811 (U-937 cl1-22)CVCL_8765 (U-937 DE-4)CVCL_U631 (U-937 GTB)
CVCL_C8E1 (U-937 INPP5D KO)CVCL_WV56 (U-937 RERC)CVCL_X000 (U-937-AG)
CVCL_C8Y0 (U-937-Luc)CVCL_WV55 (U-937/CR)CVCL_VG84 (U-M)
CVCL_M769 (U1/HIV-1)CVCL_M770 (U38)CVCL_8927 (U937(CD59+))
CVCL_8932 (U937(CD59-))CVCL_E9WW (U937(G))CVCL_E9WX (U937(V))
CVCL_A5BW (U937-ASPI3K)CVCL_2Z95 (U937-DC-SIGN)CVCL_4V23 (U937/ara-C)
CVCL_Y170 (U937/clone21)CVCL_Y171 (U937/clone36)CVCL_Y172 (U937/clone41)
CVCL_Y173 (U937/clone49)CVCL_A5ZK (U937/EVI1)CVCL_X608 (U937/HIV-2MS)
CVCL_Y174 (U937/UK110)CVCL_Y175 (U937/UK711)CVCL_8466 (YAA)
CVCL_8467 (YAP)
Sex of cell Male
Age at sampling 37Y
Category Cancer cell line
STR profile Source(s): AddexBio=C0003005/72; ATCC=CRL-1593.2; CCRID; CLS=300368; COG; DSMZ=ACC-5; ECACC=85011440; JCRB=IFO50038; JCRB=JCRB9021; KCLB=21593.1; PubMed=11416159; PubMed=15637111; PubMed=25877200; PubMed=34707142; RCB=RCB1978; Technion Genomics Center

Markers:
AmelogeninX
CSF1PO10,12 (DSMZ=ACC-5; PubMed=15637111)
12 (AddexBio=C0003005/72; ATCC=CRL-1593.2; CCRID; CLS=300368; COG; ECACC=85011440; JCRB=IFO50038; JCRB=JCRB9021; KCLB=21593.1; PubMed=25877200; PubMed=34707142; RCB=RCB1978; Technion Genomics Center)
D1S165617.3
D2S44110
D2S133817 (DSMZ=ACC-5)
17,20 (ATCC=CRL-1593.2; CCRID; CLS=300368; COG; PubMed=34707142; Technion Genomics Center)
D3S135816 (ATCC=CRL-1593.2; CCRID; CLS=300368; COG; PubMed=25877200; PubMed=34707142; Technion Genomics Center)
16,17 (DSMZ=ACC-5)
D5S81810,12 (PubMed=15637111)
10,12,13 (DSMZ=ACC-5)
12 (AddexBio=C0003005/72; ATCC=CRL-1593.2; CCRID; CLS=300368; COG; ECACC=85011440; JCRB=IFO50038; JCRB=JCRB9021; KCLB=21593.1; PubMed=25877200; PubMed=34707142; RCB=RCB1978; Technion Genomics Center)
D7S8209,11
D8S117912,13
D10S124814
D12S39117,18
D13S31710,12
D16S53912
D18S5113,14
D19S43314,16
D21S1127 (DSMZ=ACC-5; PubMed=15637111)
27,29 (ATCC=CRL-1593.2; CCRID; CLS=300368; COG; PubMed=25877200; PubMed=34707142; Technion Genomics Center)
D22S104517
FGA22,25
Penta D12,13 (ATCC=CRL-1593.2; CLS=300368; COG; PubMed=25877200; Technion Genomics Center)
13 (DSMZ=ACC-5; PubMed=15637111)
Penta E13
TH016,9.3 (AddexBio=C0003005/72; ATCC=CRL-1593.2; CCRID; CLS=300368; COG; DSMZ=ACC-5; ECACC=85011440; JCRB=IFO50038; JCRB=JCRB9021; PubMed=11416159; PubMed=15637111; PubMed=25877200; PubMed=34707142; RCB=RCB1978; Technion Genomics Center)
9.3 (KCLB=21593.1)
TPOX8,11
vWA14,15 (AddexBio=C0003005/72; ATCC=CRL-1593.2; CCRID; CLS=300368; COG; DSMZ=ACC-5; ECACC=85011440; JCRB=IFO50038; JCRB=JCRB9021; PubMed=11416159; PubMed=15637111; PubMed=25877200; RCB=RCB1978; Technion Genomics Center)
15 (KCLB=21593.1; PubMed=34707142)

Run an STR similarity search on this cell line
Web pages Info; -; -; https://web.archive.org/web/20201109215324/www.infarktforschung.de/macrophages_cell_lines.html
Info; ATCC; -; https://www.atcc.org/en/support/technical-support/faqs/growth-and-morphology-of-atcc-item-crl-1593-2
Info; COPE; -; http://www.cells-talk.com/index.php/page/copelibrary?key=U937
Info; HPA; -; https://www.proteinatlas.org/learn/cellines
Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/u/cell-lines-detail-315.html
Info; Wikipedia; -; https://en.wikipedia.org/wiki/U937_cells
Provider; NIBSC; 0012; http://www.nibsc.org/Default.aspx?pageid=597&id=0012&theme=default
Publications

DOI=10.1007/978-1-4757-1647-4_13
June Lee Biedler;
Chromosome abnormalities in human tumor cells in culture.
(In book chapter) Human tumor cells in vitro; Fogh, Jorgen (eds.); pp.359-394; Springer; New York; USA (1975)

PubMed=178611; DOI=10.1002/ijc.2910170504
Christer Sundstrom, Kenneth Nilsson;
Establishment and characterization of a human histiocytic lymphoma cell line (U-937).
Int. J. Cancer 17:565-577(1976)

PubMed=1083890; DOI=10.1084/jem.143.6.1528; PMCID=PMC2190228
Peter Ralph, Malcolm A.S. Moore, Kenneth Nilsson;
Lysozyme synthesis by established human and murine histiocytic lymphoma cell lines.
J. Exp. Med. 143:1528-1533(1976)

PubMed=6091813; DOI=10.1182/blood.V64.5.1059.1059
Antonio Palumbo, Jun Minowada, Jan Erikson, Carlo Maria Croce, Giovanni Rovera;
Lineage infidelity of a human myelogenous leukemia cell line.
Blood 64:1059-1063(1984)

PubMed=6582512; DOI=10.1073/pnas.81.2.568; PMCID=PMC344720
Michael Jules Mattes, Carlos Cordon-Cardo, John L. Lewis Jr., Lloyd John Old, Kenneth Oliver Lloyd;
Cell surface antigens of human ovarian and endometrial carcinoma defined by mouse monoclonal antibodies.
Proc. Natl. Acad. Sci. U.S.A. 81:568-572(1984)

PubMed=2985879; DOI=10.1016/0145-2126(85)90084-0
Hans Gunther Drexler, Gerhard Gaedicke, Jun Minowada;
Isoenzyme studies in human leukemia-lymphoma cell lines -- 1 Carboxylic esterase.
Leuk. Res. 9:209-229(1985)

PubMed=3159941; DOI=10.1016/0145-2126(85)90134-1
Hans Gunther Drexler, Gerhard Gaedicke, Jun Minowada;
Isoenzyme studies in human leukemia-lymphoma cell lines -- III Beta-hexosaminidase (E.C. 3.2.1.30).
Leuk. Res. 9:549-559(1985)

PubMed=3874327; DOI=10.1016/0145-2126(85)90133-x
Hans Gunther Drexler, Gerhard Gaedicke, Jun Minowada;
Isoenzyme studies in human leukemia-lymphoma cells lines -- II. Acid phosphatase.
Leuk. Res. 9:537-548(1985)

DOI=10.1159/000415060
Shigeru Morikawa, Takayuki Harada, Taizo Katoh, Makoto Nagasaki, Hiroko Nakano, Keiko Morikawa;
Heterogeneity of cellular origins in human malignant lymphoma cell line derived from histo-monocytic lineage cells.
(In book chapter) Cellular, molecular, genetic approaches to immunodiagnosis and immunotherapy. 8th International conference on labeled antibodies, Tokyo, November 1985; Kano, Kyoichi & Mori, Shigeo & Sugisaki, Testuzo & Torisu, Motomichi (eds.); pp.373-380; Karger; Basel; Switzerland (1988)

PubMed=2140233; DOI=10.1111/j.1440-1827.1990.tb01549.x
Akinobu Nakano, Takayuki Harada, Shigeru Morikawa, Yuzuru Kato;
Expression of leukocyte common antigen (CD45) on various human leukemia/lymphoma cell lines.
Acta Pathol. Jpn. 40:107-115(1990)

PubMed=2243057; DOI=10.1007/BF02624468
Zwe-Ling Kong, Misao Miwa, Hiroki Murakami, Kazuki Shinohara;
Establishment of a macrophagelike cell line derived from U-937, human histiocytic lymphoma, grown serum-free.
In Vitro Cell. Dev. Biol. 26:949-954(1990)

DOI=10.1007/978-94-011-3550-4_20
Kazuki Shinohara, Zwe-Ling Kong, Hiroki Murakami;
Characterization of a human derived macrophage-like cell line, U-M.
(In book chapter) Animal cell culture and production of biologicals; Sasaki, Ryuzo & Ikura, Koji (eds.); pp.181-186; Springer; Dordrecht; Netherlands (1991)

PubMed=1913629; DOI=10.1016/0304-3835(91)90051-I
Kenneth S.-S. Chang, W.-T. Liu, Steven F. Josephs;
Regulation of cellular trans-activating activities in two different promonocytic leukemia cell lines.
Cancer Lett. 60:75-83(1991)

PubMed=1571549; DOI=10.1182/blood.V79.9.2378.2378
Koichi Sugimoto, Hideo Toyoshima, Ryuichi Sakai, Kiyoshi Miyagawa, Koichi Hagiwara, Fuyuki Ishikawa, Fumimaro Takaku, Yoshio Yazaki, Hisamaru Hirai;
Frequent mutations in the p53 gene in human myeloid leukemia cell lines.
Blood 79:2378-2383(1992)

PubMed=8300570; DOI=10.1016/S0021-9258(17)41964-8
Eric H. Rubin, Panayotis Pantazis, Ajit Bharti, Deborah Toppmeyer, Beppino Carlo Giovanella, Donald William Kufe;
Identification of a mutant human topoisomerase I with intact catalytic activity and resistance to 9-nitro-camptothecin.
J. Biol. Chem. 269:2433-2439(1994)

PubMed=7759961; DOI=10.1002/jlb.57.5.804
Yvonne A. Reid, Linda McGuire, Kathleen O'Neill, Marvin L. Macy, Tchaw-Ren Chen, Patrick R. McClintock, Catherine S. Dorotinsky, Robert J. Hay;
Cell line cross-contamination of U-937.
J. Leukoc. Biol. 57:804-804(1995)

PubMed=8547074; DOI=10.1111/j.1365-2141.1995.tb05302.x
Reiner Siebert, Christoph P. Willers, Alexander Schramm, Alexander Fossa, Irina M. Gana Dresen, Michael J. Uppenkamp, Mohammad Resa Nowrousian, Siegfried Seeber, Bertram Opalka;
Homozygous loss of the MTS1/p16 and MTS2/p15 genes in lymphoma and lymphoblastic leukaemia cell lines.
Br. J. Haematol. 91:350-354(1995)

PubMed=8558913
S. Morita, S. Tsuchiya, Hiromi Fujie, Masayuki Itano, Yoshiyuki Ohashi, Masayoshi Minegishi, Masue Imaizumi, M. Endo, Nagako Takano, Tasuke Konno;
Cell surface c-kit receptors in human leukemia cell lines and pediatric leukemia: selective preservation of c-kit expression on megakaryoblastic cell lines during adaptation to in vitro culture.
Leukemia 10:102-105(1996)

PubMed=8558920
Wilhelm Gerhard Dirks, Margarete Zaborski, Kathrin Jager, Cecile Challier, Mami Shiota, Hilmar Quentmeier, Hans Gunther Drexler;
The (2;5)(p23;q35) translocation in cell lines derived from malignant lymphomas: absence of t(2;5) in Hodgkin-analogous cell lines.
Leukemia 10:142-149(1996)

PubMed=8643484; DOI=10.1073/pnas.93.10.4804; PMCID=PMC39360
Martin Heinz Dreyling, Jose Angel Martinez-Climent, Meng Zheng, Jen-i Mao, Janet Davison Rowley, Stefan Klaus Bohlander;
The t(10;11)(p13;q14) in the U937 cell line results in the fusion of the AF10 gene and CALM, encoding a new member of the AP-3 clathrin assembly protein family.
Proc. Natl. Acad. Sci. U.S.A. 93:4804-4809(1996)

PubMed=9371509
Ahamed Saleem, Nageatte Ibrahim, Milan Patel, Xi-Guang Li, Elora Gupta, John T. Mendoza, Panayotis Pantazis, Eric H. Rubin;
Mechanisms of resistance in a human cell line exposed to sequential topoisomerase poisoning.
Cancer Res. 57:5100-5106(1997)

PubMed=9510473; DOI=10.1111/j.1349-7006.1998.tb00476.x; PMCID=PMC5921588
Noriko Hosoya, Akira Hangaishi, Seishi Ogawa, Kiyoshi Miyagawa, Kinuko Mitani, Yoshio Yazaki, Hisamaru Hirai;
Frameshift mutations of the hMSH6 gene in human leukemia cell lines.
Jpn. J. Cancer Res. 89:33-39(1998)

PubMed=9685479; DOI=10.1093/nar/26.16.3651; PMCID=PMC147775
Magnus Hultdin, Elisabeth Gronlund, Karl-Frederik Norrback, E. Eriksson-Lindstrom, Tom Just, Goran Roos;
Telomere analysis by fluorescence in situ hybridization and flow cytometry.
Nucleic Acids Res. 26:3651-3656(1998)

PubMed=9738977; DOI=10.1111/j.1349-7006.1998.tb03275.x; PMCID=PMC5921886
Jun Takizawa, Ritsuro Suzuki, Hiroyuki Kuroda, Atae Utsunomiya, Yoshitoyo Kagami, Tatsuroh Joh, Yoshifusa Aizawa, Ryuzo Ueda, Masao Seto;
Expression of the TCL1 gene at 14q32 in B-cell malignancies but not in adult T-cell leukemia.
Jpn. J. Cancer Res. 89:712-718(1998)

PubMed=10352142; DOI=10.1096/fasebj.13.9001.s23
Jason P. Hatton, Francois Gaubert, Marian L. Lewis, Yann Darsel, Philippe Ohlmann, Jean-Pierre Cazenave, Didier Schmitt;
The kinetics of translocation and cellular quantity of protein kinase C in human leukocytes are modified during spaceflight.
FASEB J. 13 Suppl. 1:S23-S33(1999)

PubMed=10676951; DOI=10.1038/35000501
Ash Arash Alizadeh, Michael Bruce Eisen, R. Eric Davis, Chi Ma, Izidore S. Lossos, Andreas Rosenwald, Jennifer Connolly Boldrick, Hajeer Sabet, Truc Tran, Xin Yu, John I. Powell ...Show all 31 authors... , Li-Ming Yang, Gerald E. Marti, Troy Moore, James Hudson Jr., Li-Sheng Lu, David B. Lewis, Robert Tibshirani, Gavin Sherlock, Wing-Chung Chan, Timothy Charles Greiner, Dennis D. Weisenburger, James Olen Armitage, Roger Allen Warnke, Ronald Levy, Wyndham H. Wilson, Michael Rhodes Grever, John C. Byrd, David Botstein, Patrick O'Reilly Brown, Louis Michael Staudt; Show fewer authors
Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling.
Nature 403:503-511(2000)

PubMed=10739008; DOI=10.1016/S0145-2126(99)00182-4
Kaoru Inoue, Takashi Kohno, Satoshi Takakura, Yasuhide Hayashi, Hideaki Mizoguchi, Jun Yokota;
Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines.
Leuk. Res. 24:255-262(2000)

PubMed=10966170; DOI=10.1034/j.1600-0609.2000.90181.x
Anni Aggerholm, Kirsten Gronbaek, Per Guldberg, Peter Hokland;
Mutational analysis of the tumour suppressor gene MMAC1/PTEN in malignant myeloid disorders.
Eur. J. Haematol. 65:109-113(2000)

PubMed=11226526; DOI=10.1016/S0145-2126(00)00121-1
Kaoru Inoue, Takashi Kohno, Satoshi Takakura, Yasuhide Hayashi, Hideaki Mizoguchi, Jun Yokota;
Corrigendum to: Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines Leukemia Research 24 (2000), 255-262.
Leuk. Res. 25:275-278(2001)

PubMed=11416159; DOI=10.1073/pnas.121616198; PMCID=PMC35459
John R.W. Masters, Jim A. Thomson, Bernadette Daly-Burns, Yvonne A. Reid, Wilhelm Gerhard Dirks, Phil Packer, Lorraine H. Toji, Tadao Ohno, Hideyuki Tanabe, Colin Francis Arlett, Lloyd R. Kelland ...Show all 16 authors... , Maureen Harrison, Arvind K. Virmani, Timothy H. Ward, Karen L. Ayres, Paul G. Debenham; Show fewer authors
Short tandem repeat profiling provides an international reference standard for human cell lines.
Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001)

PubMed=11701946; DOI=10.1159/000048774
Jonathan C. Strefford, Nicola J. Foot, Tracy Chaplin, Michael J. Neat, R. Timothy D. Oliver, Bryan D. Young, Louise K. Jones;
The characterisation of the lymphoma cell line U937, using comparative genomic hybridisation and multi-plex FISH.
Cytogenet. Cell Genet. 94:9-14(2001)

PubMed=12393283; DOI=10.1016/S0165-4608(02)00565-4
Ji-Yun Lee, Chul-Hoon Lee, Sung Han Shim, Han-Kyu Seo, Jee-Hong Kyhm, Sechin Cho, Youl-Hee Cho;
Molecular cytogenetic analysis of the monoblastic cell line U937: karyotype clarification by G-banding, whole chromosome painting, microdissection and reverse painting, and comparative genomic hybridization.
Cancer Genet. Cytogenet. 137:124-132(2002)

PubMed=15637111; DOI=10.1096/fj.04-3062fje
Walther Parson, Romana Kirchebner, Roswitha Muhlmann, Kathrin Renner, Anita Kofler, Stefan Schmidt, Reinhard Kofler;
Cancer cell line identification by short tandem repeat profiling: power and limitations.
FASEB J. 19:434-436(2005)

PubMed=15843827; DOI=10.1038/sj.leu.2403749
Anna K. Hagstrom-Andersson, Patrik Eden, David Lindgren, Jens Nilsson, Carin Lassen, Jesper Heldrup, Magnus Fontes, Ake Borg, Felix Mitelman, Bertil Johansson, Mattias Hoglund, Thoas Fioretos;
Gene expression profiling of leukemic cell lines reveals conserved molecular signatures among subtypes with specific genetic aberrations.
Leukemia 19:1042-1050(2005)

PubMed=16311011; DOI=10.1016/j.tiv.2005.10.012
Takao Ashikaga, Yukiko Yoshida, Morihiko Hirota, Katsurako Yoneyama, Hiroshi Itagaki, Hitoshi Sakaguchi, Masaaki Miyazawa, Yuichi Ito, Hiroyuki Suzuki, Hidekazu Toyoda;
Development of an in vitro skin sensitization test using human cell lines: the human Cell Line Activation Test (h-CLAT). I. Optimization of the h-CLAT protocol.
Toxicol. In Vitro 20:767-773(2006)

PubMed=16337770; DOI=10.1016/j.tiv.2005.10.014
Hitoshi Sakaguchi, Takao Ashikaga, Masaaki Miyazawa, Yukiko Yoshida, Yuichi Ito, Katsurako Yoneyama, Morihiko Hirota, Hiroshi Itagaki, Hidekazu Toyoda, Hiroyuki Suzuki;
Development of an in vitro skin sensitization test using human cell lines; human Cell Line Activation Test (h-CLAT). II. An inter-laboratory study of the h-CLAT.
Toxicol. In Vitro 20:774-784(2006)

PubMed=16408098; DOI=10.1038/sj.leu.2404081
Hilmar Quentmeier, Roderick A.F. MacLeod, Margarete Zaborski, Hans Gunther Drexler;
JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
Leukemia 20:471-476(2006)

PubMed=16957166; DOI=10.1369/jhc.6A7001.2006; PMCID=PMC3958123
Ann-Catrin Andersson, Sara Stromberg, Helena Backvall, Caroline Kampf, Mathias Uhlen, Kenneth Wester, Fredrik Ponten;
Analysis of protein expression in cell microarrays: a tool for antibody-based proteomics.
J. Histochem. Cytochem. 54:1413-1423(2006)

PubMed=20801507; DOI=10.1016/j.leukres.2010.07.040
Luigi Minafra, Gianluca Di Cara, Nadia Ninfa Albanese, Patrizia Cancemi;
Proteomic differentiation pattern in the U937 cell line.
Leuk. Res. 35:226-236(2011)

PubMed=21269460; DOI=10.1186/1752-0509-5-17; PMCID=PMC3039570
Thomas R. Burkard, Melanie Planyavsky, Ines Kaupe, Florian P. Breitwieser, Tilmann Burckstummer, Keiryn L. Bennett, Giulio Superti-Furga, Jacques Colinge;
Initial characterization of the human central proteome.
BMC Syst. Biol. 5:17.1-17.13(2011)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

DOI=10.1016/j.actaastro.2013.06.007
Katrin Paulsen, Svantje Tauber, Nadine Golz, Dana Michaela Simmet, Stephanie Engeli, Maria Birlem, Claudia Dumrese, Anissja Karer, Sandra Hunziker, Josefine Biskup, Shalimar Konopasek ...Show all 19 authors... , Durie Suh, Eva Breuer-Hurlimann, Christoph Signer, Anna Wang, Chen Sang, Karl-Heinrich Grote, Feng-Yuan Zhuang, Oliver Ullrich; Show fewer authors
Severe disruption of the cytoskeleton and immunologically relevant surface molecules in a human macrophageal cell line in microgravity -- results of an in vitro experiment on board of the Shenzhou-8 space mission.
Acta Astronaut. 94:277-292(2013)

PubMed=25485619; DOI=10.1038/nbt.3080
Christiaan Klijn, Steffen Durinck, Eric W. Stawiski, Peter M. Haverty, Zhao-Shi Jiang, Han-Bin Liu, Jeremiah Degenhardt, Oleg Mayba, Florian Gnad, Jin-Feng Liu, Gregoire Pau ...Show all 30 authors... , Jens Reeder, Yi Cao, Kiran Mukhyala, Suresh K. Selvaraj, Ma-Mie Yu, Gregory J. Zynda, Matthew J. Brauer, Thomas D. Wu, Robert Clifford Gentleman, Gerard Manning, Robert L. Yauch, Richard Bourgon, David Stokoe, Zora Modrusan, Richard M. Neve, Frederic J. de Sauvage, Jeffrey Settleman, Somasekar Seshagiri, Ze-Min Zhang; Show fewer authors
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=29787063; DOI=10.1007/978-3-319-16104-4_14
Wasaporn Chanput, Vera Peters, Harry J. Wichers;
THP-1 and U937 cells.
(In book chapter) The impact of food bioactives on health. In vitro and ex vivo models; Verhoeckx, Kitty & Cotter, Paul David & Lopez-Exposito, Ivan & Kleiveland, Charlotte Ramstad & Lea, Tor & Mackie, Alan Robert & Requena, Teresa & Swiatecka, Dominika & Wichers, Harry J. (eds.); pp.147-159; Springer; Cham; Switzerland (2015)

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Kar-Tong Tan, Ling-Wen Ding, Qiao-Yang Sun, Zhen-Tang Lao, Wenwen Chien, Xi Ren, Jin-Fen Xiao, Xin-Yi Loh, Liang Xu, Michael Lill, Anand Mayakonda ...Show all 14 authors... , De-Chen Lin, Henry He Yang, Harold Phillip Koeffler; Show fewer authors
Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.
BMC Cancer 18:940.1-940.13(2018)

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Cord C. Uphoff, Claudia Pommerenke, Sabine A. Denkmann, Hans Gunther Drexler;
Screening human cell lines for viral infections applying RNA-Seq data analysis.
PLoS ONE 14:e0210404.1-e0210404.22(2019)

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Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
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Nature 569:503-508(2019)

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The LL-100 panel: 100 cell lines for blood cancer studies.
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Cell 180:387-402.e16(2020)

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Detailed molecular cytogenetic characterisation of the myeloid cell line U937 reveals the fate of homologous chromosomes and shows that centromere capture is a feature of genome instability.
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Int. J. Mol. Sci. 24:5377.1-5377.34(2023)

Cross-references
Cell line collections (Providers) AddexBio; C0003005/72
ATCC; CRL-1593 - Discontinued
ATCC; CRL-1593.2
BCRC; 60435
BCRJ; 0242
CCTCC; GDC0080
CLS; 300368
DSMZ; ACC-5
ECACC; 85011440
ICLC; HTL94002
IZSLER; BS TCL 73
JCRB; IFO50038
JCRB; JCRB9021
KCB; KCB 200676YJ
KCLB; 21593.1
NCBI_Iran; C130
RCB; RCB1978 - Discontinued
TKG; TKG 0279 - Discontinued
Ubigene; YC-C021
Cell line databases/resources CLO; CLO_0009450
CLO; CLO_0009465
MCCL; MCC:0000470
CLDB; cl4597
CLDB; cl4599
CLDB; cl4600
CLDB; cl4601
CLDB; cl4602
CLDB; cl4603
CLDB; cl4604
CLDB; cl4605
CLDB; cl4606
CLDB; cl4608
cancercelllines; CVCL_0007
CCRID; 1101HUM-PUMC000059
CCRID; 3101HUMTCHu159
CCRID; 4201HUM-CCTCC00080
Cell_Model_Passport; SIDM01195
DepMap; ACH-000406
DSMZCellDive; ACC-5
IPD-IMGT/HLA; 11507
LINCS_HMS; 50869
LINCS_LDP; LCL-1125
Lonza; 135
TOKU-E; 3382
Anatomy/cell type resources BTO; BTO_0001412
Biological sample resources BioSample; SAMN03472409
BioSample; SAMN03473173
BioSample; SAMN03473567
BioSample; SAMN10988180
CRISP screens repositories BioGRID_ORCS_Cell_line; 154
Chemistry resources ChEMBL-Cells; CHEMBL3308006
ChEMBL-Targets; CHEMBL612794
PharmacoDB; U937_1624_2019
PubChem_Cell_line; CVCL_0007
Encyclopedic resources Wikidata; Q7863610
Experimental variables resources EFO; EFO_0001257
Gene expression databases ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-7721
ArrayExpress; E-MTAB-7722
GEO; GSE66854
GEO; GSM2020
GEO; GSM236809
GEO; GSM236845
GEO; GSM482491
GEO; GSM743413
GEO; GSM887724
GEO; GSM888818
GEO; GSM1028244
GEO; GSM1028245
GEO; GSM1374975
GEO; GSM1670560
GEO; GSM7701385
GEO; GSM7701386
GEO; GSM7701402
GEO; GSM7701403
Medical resources MeSH; D020298
Polymorphism and mutation databases Cosmic; 787483
Cosmic; 798666
Cosmic; 821044
Cosmic; 850382
Cosmic; 852000
Cosmic; 919123
Cosmic; 922162
Cosmic; 932770
Cosmic; 947364
Cosmic; 975307
Cosmic; 991558
Cosmic; 994178
Cosmic; 999781
Cosmic; 1012127
Cosmic; 1019837
Cosmic; 1067446
Cosmic; 1070690
Cosmic; 1078726
Cosmic; 1082516
Cosmic; 1086353
Cosmic; 1089523
Cosmic; 1107178
Cosmic; 1127260
Cosmic; 1150904
Cosmic; 1176581
Cosmic; 1181605
Cosmic; 1191692
Cosmic; 1465967
Cosmic; 1523828
Cosmic; 1524826
Cosmic; 1582388
Cosmic; 1601066
Cosmic; 1604865
Cosmic; 1995661
Cosmic; 2301570
Cosmic; 2361376
Cosmic; 2750876
IARC_TP53; 2199
LiGeA; CCLE_826
Progenetix; CVCL_0007
Proteomic databases PRIDE; PXD001521
PRIDE; PXD001522
PRIDE; PXD001523
Sequence databases EGA; EGAS00001000610
EGA; EGAS00001002554
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number50