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Cellosaurus MBU-8 (CVCL_B3XV)

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Cell line name MBU-8
Accession CVCL_B3XV
Resource Identification Initiative To cite this cell line use: MBU-8 (RRID:CVCL_B3XV)
Comments Population: Caucasian.
Doubling time: 30-40 hours (Direct_author_submission); ~30 hours (DSMZ=ACC-910).
Karyotypic information: Compared to the parent cell line, has a complete trisomy of chromosome 18 as well as a partial trisomy of 7 and tetrasomy of 8p (PubMed=34707142).
Miscellaneous: Doubling time from personal communication of Diesch, Jeannine.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; HGNC:16063; MLLT10 + HGNC; HGNC:15514; PICALM; Name(s)=PICALM-MLLT10, CALM-AF10 (PubMed=34707142).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Gly129fs*51 (c.387_388insCGCC); Zygosity=Hemizygous (from parent cell line).
  • Mutation; HGNC; HGNC:9644; PTPN11; Simple; p.Gly60Arg (c.178G>C); ClinVar=VCV000372590; Zygosity=Heterozygous (PubMed=34707142).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; c.559+1G>A (p.Val173Trpfs*59); ClinVar=VCV000428908; Zygosity=Homozygous; Note=Splice donor mutation (PubMed=34707142).
  • Mutation; HGNC; HGNC:12796; WT1; Simple; p.Arg301Ter (c.901C>T) (p.Arg352Ter, c.1054C>T) (p.Arg374Ter, c.1120C>T); ClinVar=VCV000449416; Zygosity=Heterozygous (PubMed=34707142).
Disease Adult acute monocytic leukemia (NCIt: C8263)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0007 (U-937)
Sex of cell Male
Age at sampling 37Y
Category Cancer cell line
STR profile Source(s): DSMZ=ACC-910; PubMed=34707142

Markers:
AmelogeninX
CSF1PO12
D2S133817,20
D3S135816
D5S81812
D7S8209,11
D8S117912,13
D13S31710,12
D16S53912
D18S5113,14
D19S43314,16
D21S1127,29
FGA22,25
Penta D12,13
Penta E13
TH016,9.3
TPOX8,11
vWA14,15

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Publications

PubMed=34707142; DOI=10.1038/s41598-021-00623-w; PMCID=PMC8551338
Michael Maher, Jeannine Diesch, Marguerite-Marie Le Pannerer, Marta Cabezon, Mar Mallo, Sara Vergara, Aleix Mendez Lopez, Alba Mesa Tudel, Francesc Sole, Marc Sorigue, Lurdes Zamora ...Show all 13 authors... , Isabel Granada, Marcus Buschbeck; Show fewer authors
Divergent leukaemia subclones as cellular models for testing vulnerabilities associated with gains in chromosomes 7, 8 or 18.
Sci. Rep. 11:21145.1-21145.11(2021)

Cross-references
Cell line collections (Providers) DSMZ; ACC-910
Cell line databases/resources cancercelllines; CVCL_B3XV
DSMZCellDive; ACC-910
Encyclopedic resources Wikidata; Q110433018
Entry history
Entry creation16-Dec-2021
Last entry update19-Dec-2024
Version number10