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Cellosaurus U937/clone36 (CVCL_Y171)

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Cell line name U937/clone36
Accession CVCL_Y171
Resource Identification Initiative To cite this cell line use: U937/clone36 (RRID:CVCL_Y171)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_4911; Etoposide (VP-16).
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; HGNC:16063; MLLT10 + HGNC; HGNC:15514; PICALM; Name(s)=PICALM-MLLT10, CALM-AF10 (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Gly129fs*51 (c.387_388insCGCC); Zygosity=Hemizygous (from parent cell line).
  • Mutation; HGNC; HGNC:9644; PTPN11; Simple; p.Gly60Arg (c.178G>C); ClinVar=VCV000372590; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; c.559+1G>A (p.Val173Trpfs*59); ClinVar=VCV000428908; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
Disease Adult acute monocytic leukemia (NCIt: C8263)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0007 (U-937)
Sex of cell Male
Age at sampling 37Y
Category Cancer cell line
Publications

PubMed=14973057; DOI=10.1158/0008-5472.CAN-3263-2
Kohichiroh Yasui, Saori Mihara, Chen Zhao, Hiroyuki Okamoto, Fumiko Saito-Ohara, Akihiro Tomida, Tadao Funato, Akira Yokomizo, Seiji Naito, Issei Imoto, Takashi Tsuruo, Johji Inazawa;
Alteration in copy numbers of genes as a mechanism for acquired drug resistance.
Cancer Res. 64:1403-1410(2004)

Cross-references
Cell line databases/resources cancercelllines; CVCL_Y171
CGH-DB; 9117-4
Encyclopedic resources Wikidata; Q54973780
Entry history
Entry creation07-Nov-2014
Last entry update19-Dec-2024
Version number15