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Cellosaurus SC [Human contaminated U-937] (CVCL_6444)

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Cell line name SC [Human contaminated U-937]
Synonyms 28SC
Accession CVCL_6444
Resource Identification Initiative To cite this cell line use: SC [Human contaminated U-937] (RRID:CVCL_6444)
Comments Group: Patented cell line.
Problematic cell line: Contaminated. On the basis of the STR profile it seems to be a U-937 derivative.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00525.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-9855.
Population: Caucasian.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; HGNC:16063; MLLT10 + HGNC; HGNC:15514; PICALM; Name(s)=PICALM-MLLT10, CALM-AF10 (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Gly129fs*51 (c.387_388insCGCC); Zygosity=Hemizygous (from parent cell line).
  • Mutation; HGNC; HGNC:9644; PTPN11; Simple; p.Gly60Arg (c.178G>C); ClinVar=VCV000372590; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; c.559+1G>A (p.Val173Trpfs*59); ClinVar=VCV000428908; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
  • Mutation; HGNC; HGNC:12796; WT1; Simple; p.Arg301Ter (c.901C>T) (p.Arg352Ter, c.1054C>T) (p.Arg374Ter, c.1120C>T); ClinVar=VCV000449416; Zygosity=Heterozygous (from parent cell line).
Disease Adult acute monocytic leukemia (NCIt: C8263)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0007 (U-937)
Children:
CVCL_EP74 (28SC-ES)
Sex of cell Male
Age at sampling 37Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-3622

Markers:
AmelogeninX
CSF1PO10,12
D5S81810,12
D7S8209,11
D13S31710,12
D16S53912
TH016,9.3
TPOX8,11
vWA15

Run an STR similarity search on this cell line
Web pages Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

Patent=US5447861
Geary W. Collins, Michael T. Largen;
Continuous mammalian cell lines having monocyte/macrophage characteristics and their establishment in vitro.
Patent number US5447861, 05-Sep-1995

Cross-references
Cell line collections (Providers) ATCC; CRL-3622
ATCC; CRL-9855 - Discontinued
Cell line databases/resources CLO; CLO_0008954
cancercelllines; CVCL_6444
Encyclopedic resources Wikidata; Q54952220
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number24