Cell line name |
U937-ASPI3K |
Accession |
CVCL_A5BW |
Resource Identification Initiative |
To cite this cell line use: U937-ASPI3K (RRID:CVCL_A5BW) |
Comments |
Population: Caucasian. Transfected with: HGNC; 795; ATM (anti-sense). Transfected with: UniProtKB; P17493; Streptoalloteichus hindustanus ble (BleoR). Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175. |
Sequence variations |
- Gene fusion; HGNC; 16063; MLLT10 + HGNC; 15514; PICALM; Name(s)=PICALM-MLLT10, CALM-AF10 (from parent cell line).
- Mutation; HGNC; 9588; PTEN; Simple; p.Gly129fs*51 (c.387_388insCGCC); Zygosity=Hemizygous (from parent cell line).
- Mutation; HGNC; 9644; PTPN11; Simple; p.Gly60Arg (c.178G>C); ClinVar=VCV000372590; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; c.559+1G>A (p.Val173Trpfs*59); ClinVar=VCV000428908; Zygosity=Homozygous; Note=Splice donor mutation (Cosmic-CLP).
- Mutation; HGNC; 12796; WT1; Simple; p.Arg301Ter (c.901C>T) (p.Arg352Ter, c.1054C>T) (p.Arg374Ter, c.1120C>T); ClinVar=VCV000449416; Zygosity=Heterozygous (from parent cell line).
|
Disease |
Adult acute monocytic leukemia (NCIt: C8263) Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_0007 (U-937) |
Sex of cell |
Male |
Age at sampling |
37Y |
Category |
Cancer cell line |
Publications | PubMed=12840909; DOI=10.1007/BF02888177 Zhou J.-F., Liu W.-L., Sun L., Sun H.-Y., Tang Y. Multiple defects of cell cycle checkpoints in U937-ASPI3K, an U937 cell mutant stably expressing anti-sense ATM gene cDNA. J. Tongji Med. Univ. 20:273-276(2000) PubMed=12578639 Zhou J.-F., Liu W.-L., Tang Y., Dai Q.-L., Sun L. Establishment of the cell line U937-ASPI3K with stable expression of antisense ATM/PI3K. Zhongguo Shi Yan Xue Ye Xue Za Zhi 9:22-25(2001) |
Cross-references |
Cell line databases/resources |
cancercelllines; CVCL_A5BW
|
Encyclopedic resources |
Wikidata; Q107117182
|
Entry history |
Entry creation | 20-May-2021 |
Last entry update | 05-Oct-2023 |
Version number | 6 |
---|