| Cell line name |
U937-ASPI3K |
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| Accession |
CVCL_A5BW |
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| Resource Identification Initiative |
To cite this cell line use: U937-ASPI3K (RRID:CVCL_A5BW) |
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| Comments |
Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:795; ATM (Note=In antisense orientation).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P17493; Streptoalloteichus hindustanus ble (BleoR).
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175. |
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| Sequence variations |
- Gene fusion; HGNC; HGNC:16063; MLLT10 + HGNC; HGNC:15514; PICALM; Name(s)=PICALM-MLLT10, CALM-AF10 (from parent cell line).
- Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Gly129fs*51 (c.387_388insCGCC); Zygosity=Hemizygous (from parent cell line).
- Mutation; HGNC; HGNC:9644; PTPN11; Simple; p.Gly60Arg (c.178G>C); ClinVar=VCV000372590; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; c.559+1G>A (p.Val173Trpfs*59); ClinVar=VCV000428908; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
- Mutation; HGNC; HGNC:12796; WT1; Simple; p.Arg301Ter (c.901C>T) (p.Arg352Ter, c.1054C>T) (p.Arg374Ter, c.1120C>T); ClinVar=VCV000449416; Zygosity=Heterozygous (from parent cell line).
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| Disease |
Adult acute monocytic leukemia (NCIt: C8263)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0007 (U-937) |
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| Sex of cell |
Male |
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| Age at sampling |
37Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=12840909; DOI=10.1007/BF02888177
Jian-Feng Zhou, Wen-Li Liu, Lan Sun, Han-Ying Sun, Yi Tang;
Multiple defects of cell cycle checkpoints in U937-ASPI3K, an U937 cell mutant stably expressing anti-sense ATM gene cDNA.
J. Tongji Med. Univ. 20:273-276(2000) PubMed=12578639
Jian-Feng Zhou, Wen-Li Liu, Yi Tang, Qi-Lin Dai, Lan Sun;
Establishment of the cell line U937-ASPI3K with stable expression of antisense ATM/PI3K.
Zhongguo Shi Yan Xue Ye Xue Za Zhi 9:22-25(2001) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_A5BW
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| Encyclopedic resources |
Wikidata; Q107117182
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| Entry history |
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| Entry creation | 20-May-2021 |
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| Last entry update | 19-Dec-2024 |
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| Version number | 9 |
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