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Cellosaurus MOBS-1 (CVCL_8442)

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Cell line name MOBS-1
Accession CVCL_8442
Resource Identification Initiative To cite this cell line use: MOBS-1 (RRID:CVCL_8442)
Comments Problematic cell line: Contaminated. Shown to be a U-937 derivative (PubMed=12592342; PubMed=20143388). Originally thought to originate from the peripheral blood of a 57 year old male patient with monocytic leukemia (M5b).
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00239.
Population: Caucasian.
Doubling time: 12 hours (DOI=10.15369/sujms1989.9.45).
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; HGNC:16063; MLLT10 + HGNC; HGNC:15514; PICALM; Name(s)=PICALM-MLLT10, CALM-AF10 (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Gly129fs*51 (c.387_388insCGCC); Zygosity=Hemizygous (from parent cell line).
  • Mutation; HGNC; HGNC:9644; PTPN11; Simple; p.Gly60Arg (c.178G>C); ClinVar=VCV000372590; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; c.559+1G>A (p.Val173Trpfs*59); ClinVar=VCV000428908; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
  • Mutation; HGNC; HGNC:12796; WT1; Simple; p.Arg301Ter (c.901C>T) (p.Arg352Ter, c.1054C>T) (p.Arg374Ter, c.1120C>T); ClinVar=VCV000449416; Zygosity=Heterozygous (from parent cell line).
Disease Adult acute monocytic leukemia (NCIt: C8263)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0007 (U-937)
Children:
CVCL_RX32 (MABS-1)
Sex of cell Male
Age at sampling 37Y
Category Cancer cell line
Web pages Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

DOI=10.15369/sujms1989.9.45
Isao Matsuda, Sanju Iwamoto, Kazuko Aoki, Michihiro Matsumoto, Isao Shibuya, Tamio Hagiwara, Nobuyoshi Tsuruoka, Minoru Takeda, Kenichi Okamoto;
Establishment of a novel human macrophage-like cell line, MABS-1, derived from a human monocytic leukemia cell line, MOBS-1.
Showa Univ. J. Med. Sci. 9:45-55(1997)

PubMed=10233379; DOI=10.1111/j.1365-2141.1999.01284.x
Feng Xu, Tomohiko Taki, Hong-Wei Yang, Ryoji Hanada, Teruaki Hongo, Hiroaki Ohnishi, Miyuki Kobayashi, Fumio Bessho, Masayoshi Yanagisawa, Yasuhide Hayashi;
Tandem duplication of the FLT3 gene is found in acute lymphoblastic leukaemia as well as acute myeloid leukaemia but not in myelodysplastic syndrome or juvenile chronic myelogenous leukaemia in children.
Br. J. Haematol. 105:155-162(1999)

PubMed=12592342; DOI=10.1038/sj.leu.2402799
Hans Gunther Drexler, Wilhelm Gerhard Dirks, Yoshinobu Matsuo, Roderick A.F. MacLeod;
False leukemia-lymphoma cell lines: an update on over 500 cell lines.
Leukemia 17:416-426(2003)

PubMed=20143388; DOI=10.1002/ijc.25242
Amanda Capes-Davis, George Theodosopoulos, Isobel Atkin, Hans Gunther Drexler, Arihiro Kohara, Roderick A.F. MacLeod, John R.W. Masters, Yukio Nakamura, Yvonne A. Reid, Roger Robert Reddel, Robert Ian Freshney;
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

Cross-references
Cell line databases/resources cancercelllines; CVCL_8442
Biological sample resources BioSample; SAMN03151984
Encyclopedic resources Wikidata; Q54906291
Polymorphism and mutation databases Cosmic; 998752
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number28