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Cellosaurus MABS-1 (CVCL_RX32)

[Text version]
Cell line name MABS-1
Accession CVCL_RX32
Resource Identification Initiative To cite this cell line use: MABS-1 (RRID:CVCL_RX32)
Comments Problematic cell line: Contaminated. Parent cell line (MOBS-1) has been shown to be a U-937 derivative.
Population: Caucasian.
Doubling time: 20 hours (DOI=10.15369/sujms1989.9.45).
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; 16063; MLLT10 + HGNC; 15514; PICALM; Name(s)=PICALM-MLLT10, CALM-AF10 (from parent cell line).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Gly129fs*51 (c.387_388insCGCC); Zygosity=Hemizygous (from parent cell line).
  • Mutation; HGNC; 9644; PTPN11; Simple; p.Gly60Arg (c.178G>C); ClinVar=VCV000372590; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; c.559+1G>A (p.Val173Trpfs*59); ClinVar=VCV000428908; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
  • Mutation; HGNC; 12796; WT1; Simple; p.Arg301Ter (c.901C>T) (p.Arg352Ter, c.1054C>T) (p.Arg374Ter, c.1120C>T); ClinVar=VCV000449416; Zygosity=Heterozygous (from parent cell line).
Disease Adult acute monocytic leukemia (NCIt: C8263)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_8442 (MOBS-1)
Sex of cell Male
Age at sampling 37Y
Category Cancer cell line

Matsuda I., Iwamoto S., Aoki K., Matsumoto M., Shibuya I., Hagiwara T., Tsuruoka N., Takeda M., Okamoto K.
Establishment of a novel human macrophage-like cell line, MABS-1, derived from a human monocytic leukemia cell line, MOBS-1.
Showa Univ. J. Med. Sci. 9:45-55(1997)

Cell line databases/resources cancercelllines; CVCL_RX32
Encyclopedic resources Wikidata; Q54903939
Entry history
Entry creation05-Mar-2018
Last entry update05-Oct-2023
Version number11