Cellosaurus cell line MABS-1 (CVCL

Cellosaurus MABS-1 (CVCL_RX32)

[Text version]

Cell line name

MABS-1

Accession

CVCL_RX32

Resource Identification Initiative

To cite this cell line use: MABS-1 (RRID:CVCL_RX32)

Comments

Problematic cell line: Contaminated. Parent cell line (MOBS-1) has been shown to be a U-937 derivative.
Population: Caucasian.
Doubling time: 20 hours (DOI=10.15369/sujms1989.9.45).
Derived from sampling site: Pleural effusion.

Sequence variations

Gene fusion; HGNC; 16063; MLLT10 + HGNC; 15514; PICALM; Name(s)=PICALM-MLLT10, CALM-AF10 (from parent cell line).
Mutation; HGNC; 9588; PTEN; Simple; p.Gly129fs*51 (c.387_388insCGCC); Zygosity=Hemizygous (from parent cell line).
Mutation; HGNC; 9644; PTPN11; Simple; p.Gly60Arg (c.178G>C); ClinVar=VCV000372590; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 11998; TP53; Simple; c.559+1G>A (p.Val173Trpfs*59); ClinVar=VCV000428908; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
Mutation; HGNC; 12796; WT1; Simple; p.Arg301Ter (c.901C>T) (p.Arg352Ter, c.1054C>T) (p.Arg374Ter, c.1120C>T); ClinVar=VCV000449416; Zygosity=Heterozygous (from parent cell line).

Disease

Adult acute monocytic leukemia (NCIt: C8263)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Parent: CVCL_8442 (MOBS-1)
Children:

CVCL_VN20 (ELD-1)

Sex of cell

Male

Age at sampling

37Y