Cell line name |
MABS-1 |
Accession |
CVCL_RX32 |
Resource Identification Initiative |
To cite this cell line use: MABS-1 (RRID:CVCL_RX32) |
Comments |
Problematic cell line: Contaminated. Parent cell line (MOBS-1) has been shown to be a U-937 derivative. Population: Caucasian. Doubling time: 20 hours (DOI=10.15369/sujms1989.9.45). Derived from sampling site: Pleural effusion. |
Sequence variations |
- Gene fusion; HGNC; 16063; MLLT10 + HGNC; 15514; PICALM; Name(s)=PICALM-MLLT10, CALM-AF10 (from parent cell line).
- Mutation; HGNC; 9588; PTEN; Simple; p.Gly129fs*51 (c.387_388insCGCC); Zygosity=Hemizygous (from parent cell line).
- Mutation; HGNC; 9644; PTPN11; Simple; p.Gly60Arg (c.178G>C); ClinVar=VCV000372590; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; c.559+1G>A (p.Val173Trpfs*59); ClinVar=VCV000428908; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
- Mutation; HGNC; 12796; WT1; Simple; p.Arg301Ter (c.901C>T) (p.Arg352Ter, c.1054C>T) (p.Arg374Ter, c.1120C>T); ClinVar=VCV000449416; Zygosity=Heterozygous (from parent cell line).
|
Disease |
Adult acute monocytic leukemia (NCIt: C8263) Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_8442 (MOBS-1) Children:
|
Sex of cell |
Male |
Age at sampling |
37Y |
Category |
Cancer cell line |
Publications | DOI=10.15369/sujms1989.9.45 Matsuda I., Iwamoto S., Aoki K., Matsumoto M., Shibuya I., Hagiwara T., Tsuruoka N., Takeda M., Okamoto K. Establishment of a novel human macrophage-like cell line, MABS-1, derived from a human monocytic leukemia cell line, MOBS-1. Showa Univ. J. Med. Sci. 9:45-55(1997) |
Cross-references |
Encyclopedic resources |
Wikidata; Q54903939
|
Entry history |
Entry creation | 05-Mar-2018 |
Last entry update | 21-Mar-2023 |
Version number | 9 |
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