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Cellosaurus ELD-1 (CVCL_VN20)

[Text version]
Cell line name ELD-1
Accession CVCL_VN20
Resource Identification Initiative To cite this cell line use: ELD-1 (RRID:CVCL_VN20)
Comments Problematic cell line: Contaminated. Grand-parent cell line (MOBS-1) has been shown to be a U-937 derivative.
Population: Caucasian.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; 16063; MLLT10 + HGNC; 15514; PICALM; Name(s)=PICALM-MLLT10, CALM-AF10 (from parent cell line).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Gly129fs*51 (c.387_388insCGCC); Zygosity=Hemizygous (from parent cell line).
  • Mutation; HGNC; 9644; PTPN11; Simple; p.Gly60Arg (c.178G>C); ClinVar=VCV000372590; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; c.559+1G>A (p.Val173Trpfs*59); ClinVar=VCV000428908; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
  • Mutation; HGNC; 12796; WT1; Simple; p.Arg301Ter (c.901C>T) (p.Arg352Ter, c.1054C>T) (p.Arg374Ter, c.1120C>T); ClinVar=VCV000449416; Zygosity=Heterozygous (from parent cell line).
Disease Adult acute monocytic leukemia (NCIt: C8263)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_RX32 (MABS-1)
CVCL_VN21 (ELD-1 C-11)CVCL_VN22 (ELD-1 C-8)CVCL_VN23 (ELD-1 D-9)
Sex of cell Male
Age at sampling 37Y
Category Cancer cell line
Web pages https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09670754/

Iwamoto S., Sugisaki K., Shibuya I., Takeda M.
Characterization of a novel human Langerhans cell type dendritic cell line, ELD-1.
Dendritic Cells 9:41-47(1999)

PubMed=15922715; DOI=10.1016/j.cellimm.2005.01.008
Iwamoto S., Ishida M., Tamaoki S., Hagiwara T., Sueki H., Miyazaki A.
A human Langerhans cell-like cell line, ELD-1, promotes CD8 T cells to produce IFN-gamma through CD70-dependent alternative pathway.
Cell. Immunol. 232:49-56(2004)

Cell line databases/resources cancercelllines; CVCL_VN20
Encyclopedic resources Wikidata; Q93539948
Entry history
Entry creation07-Sep-2018
Last entry update05-Oct-2023
Version number10