| Cell line name |
ELD-1 C-8 |
| Synonyms |
ELD-1 subclone C-8; C-8 |
| Accession |
CVCL_VN22 |
| Resource Identification Initiative |
To cite this cell line use: ELD-1 C-8 (RRID:CVCL_VN22) |
| Comments |
Problematic cell line: Contaminated. Ancestral cell line (MOBS-1) has been shown to be a U-937 derivative. Population: Caucasian. Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175. |
| Sequence variations |
- Gene fusion; HGNC; HGNC:16063; MLLT10 + HGNC; HGNC:15514; PICALM; Name(s)=PICALM-MLLT10, CALM-AF10 (from parent cell line).
- Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Gly129fs*51 (c.387_388insCGCC); Zygosity=Hemizygous (from parent cell line).
- Mutation; HGNC; HGNC:9644; PTPN11; Simple; p.Gly60Arg (c.178G>C); ClinVar=VCV000372590; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; c.559+1G>A (p.Val173Trpfs*59); ClinVar=VCV000428908; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
- Mutation; HGNC; HGNC:12796; WT1; Simple; p.Arg301Ter (c.901C>T) (p.Arg352Ter, c.1054C>T) (p.Arg374Ter, c.1120C>T); ClinVar=VCV000449416; Zygosity=Heterozygous (from parent cell line).
|
| Disease |
Adult acute monocytic leukemia (NCIt: C8263) Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514) |
| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
| Hierarchy |
Parent: CVCL_VN20 (ELD-1) |
| Sex of cell |
Male |
| Age at sampling |
37Y |
| Category |
Cancer cell line |
| Publications | DOI=10.14930/jsma1939.62.310 Satoshi Tamaoki, Sanju Iwamoto, Makoto Ishida, Keizo Sugisaki, Kentaro Nakamura; Roles of cytokines in interferon-gamma; generation by allogeneic response between CD8 T cells and a human dendritic cell-like cell line, ELD-1 -- a model of study for CD8 T cell promotion independent helper T cells. Showa Igakkai Zasshi 62:310-320(2002) PubMed=15922715; DOI=10.1016/j.cellimm.2005.01.008 Sanju Iwamoto, Makoto Ishida, Satoshi Tamaoki, Tamio Hagiwara, Hirohiko Sueki, Akira Miyazaki; A human Langerhans cell-like cell line, ELD-1, promotes CD8 T cells to produce IFN-gamma through CD70-dependent alternative pathway. Cell. Immunol. 232:49-56(2004) |
| Cross-references |
| Cell line databases/resources |
cancercelllines; CVCL_VN22
|
| Encyclopedic resources |
Wikidata; Q93539956
|
| Entry history |
| Entry creation | 07-Sep-2018 |
| Last entry update | 19-Dec-2024 |
| Version number | 11 |
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