ID   ELD-1
AC   CVCL_VN20
DR   cancercelllines; CVCL_VN20
DR   Wikidata; Q93539948
RX   CelloPub=CLPUB00437;
RX   PubMed=15922715;
WW   Info; KAKEN; 09670754; https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-09670754/
CC   Problematic cell line: Contaminated. Grand-parent cell line (MOBS-1) has been shown to be a U-937 derivative.
CC   Population: Caucasian.
CC   Sequence variation: Gene fusion; HGNC; HGNC:16063; MLLT10 + HGNC; HGNC:15514; PICALM; Name(s)=PICALM-MLLT10, CALM-AF10 (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Gly129fs*51 (c.387_388insCGCC); Zygosity=Hemizygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9644; PTPN11; Simple; p.Gly60Arg (c.178G>C); ClinVar=VCV000372590; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; c.559+1G>A (p.Val173Trpfs*59); ClinVar=VCV000428908; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:12796; WT1; Simple; p.Arg301Ter (c.901C>T) (p.Arg352Ter, c.1054C>T) (p.Arg374Ter, c.1120C>T); ClinVar=VCV000449416; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C8263; Adult acute monocytic leukemia
DI   ORDO; Orphanet_514; Acute monoblastic/monocytic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_RX32 ! MABS-1
SX   Male
AG   37Y
CA   Cancer cell line
DT   Created: 07-09-18; Last updated: 10-04-25; Version: 12
CH   CVCL_VN21 ! ELD-1 C-11
CH   CVCL_VN22 ! ELD-1 C-8
CH   CVCL_VN23 ! ELD-1 D-9
//
RX   PubMed=15922715; DOI=10.1016/j.cellimm.2005.01.008;
RA   Iwamoto, Sanju
RA   Ishida, Makoto
RA   Tamaoki, Satoshi
RA   Hagiwara, Tamio
RA   Sueki, Hirohiko
RA   Miyazaki, Akira
RT   "A human Langerhans cell-like cell line, ELD-1, promotes CD8 T cells
RT   to produce IFN-gamma through CD70-dependent alternative pathway.";
RL   Cell. Immunol. 232:49-56(2004).
//
RX   CelloPub=CLPUB00437;
RA   Iwamoto, Sanju
RA   Sugisaki, Keizo
RA   Shibuya, Isao
RA   Takeda, Minoru
RT   "Characterization of a novel human Langerhans cell type dendritic cell
RT   line, ELD-1.";
RL   Dendritic Cells 9:41-47(1999).
//