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Cellosaurus U1/HIV-1 (CVCL_M769)

[Text version]
Cell line name U1/HIV-1
Synonyms U1
Accession CVCL_M769
Resource Identification Initiative To cite this cell line use: U1/HIV-1 (RRID:CVCL_M769)
Comments Population: Caucasian.
Virology: Latently infected with HIV-1 isolate NY5. The two main sites of integrations are in chromosome 2 and chromosome X (PubMed=28086908).
Doubling time: 36 hours (BEI_Resources=ARP-165).
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; HGNC:16063; MLLT10 + HGNC; HGNC:15514; PICALM; Name(s)=PICALM-MLLT10, CALM-AF10 (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Gly129fs*51 (c.387_388insCGCC); Zygosity=Hemizygous (from parent cell line).
  • Mutation; HGNC; HGNC:9644; PTPN11; Simple; p.Gly60Arg (c.178G>C); ClinVar=VCV000372590; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; c.559+1G>A (p.Val173Trpfs*59); ClinVar=VCV000428908; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
  • Mutation; HGNC; HGNC:12796; WT1; Simple; p.Arg301Ter (c.901C>T) (p.Arg352Ter, c.1054C>T) (p.Arg374Ter, c.1120C>T); ClinVar=VCV000449416; Zygosity=Heterozygous (from parent cell line).
Disease Adult acute monocytic leukemia (NCIt: C8263)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0007 (U-937)
Sex of cell Male
Age at sampling 37Y
Category Cancer cell line
Publications

PubMed=3313729; DOI=10.1126/science.3313729
Thomas M. Folks, Jesse Shawn Justement, Audrey L. Kinter, Charles Anthony Dinarello, Anthony Stephen Fauci;
Cytokine-induced expression of HIV-1 in a chronically infected promonocyte cell line.
Science 238:800-802(1987)

PubMed=2449497; DOI=10.4049/jimmunol.140.4.1117
Thomas M. Folks, Jesse Shawn Justement, Audrey L. Kinter, Steven Schnittman, Jan Marc Orenstein, Guido Poli, Anthony Stephen Fauci;
Characterization of a promonocyte clone chronically infected with HIV and inducible by 13-phorbol-12-myristate acetate.
J. Immunol. 140:1117-1122(1988)

PubMed=28086908; DOI=10.1186/s12977-016-0325-2; PMCID=PMC5237276
Jori Symons, Abha Chopra, Eva Malatinkova, Ward De Spiegelaere, Shay Leary, Don Cooper, Chike O. Abana, Ajantha Rhodes, Simin D. Rezaei, Linos Vandekerckhove, Simon Mallal ...Show all 13 authors... , Sharon Ruth Lewin, Paul Urquhart Cameron; Show fewer authors
HIV integration sites in latently infected cell lines: evidence of ongoing replication.
Retrovirology 14:2.1-2.11(2017)

Cross-references
Cell line collections (Providers) BEI_Resources; ARP-165
Cell line databases/resources cancercelllines; CVCL_M769
Lonza; 1169
Chemistry resources ChEMBL-Cells; CHEMBL3307351
ChEMBL-Targets; CHEMBL614246
PubChem_Cell_line; CVCL_M769
Encyclopedic resources Wikidata; Q54973623
Entry history
Entry creation05-Nov-2013
Last entry update19-Dec-2024
Version number24