Cell line name |
U1/HIV-1 |
Synonyms |
U1 |
Accession |
CVCL_M769 |
Resource Identification Initiative |
To cite this cell line use: U1/HIV-1 (RRID:CVCL_M769) |
Comments |
Population: Caucasian. Virology: Latently infected with HIV-1 isolate NY5. The two main sites of integrations are in chromosome 2 and chromosome X (PubMed=28086908). Doubling time: 36 hours (BEI_Resources=ARP-165). Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175. |
Sequence variations |
- Gene fusion; HGNC; HGNC:16063; MLLT10 + HGNC; HGNC:15514; PICALM; Name(s)=PICALM-MLLT10, CALM-AF10 (from parent cell line).
- Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Gly129fs*51 (c.387_388insCGCC); Zygosity=Hemizygous (from parent cell line).
- Mutation; HGNC; HGNC:9644; PTPN11; Simple; p.Gly60Arg (c.178G>C); ClinVar=VCV000372590; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; c.559+1G>A (p.Val173Trpfs*59); ClinVar=VCV000428908; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
- Mutation; HGNC; HGNC:12796; WT1; Simple; p.Arg301Ter (c.901C>T) (p.Arg352Ter, c.1054C>T) (p.Arg374Ter, c.1120C>T); ClinVar=VCV000449416; Zygosity=Heterozygous (from parent cell line).
|
Disease |
Adult acute monocytic leukemia (NCIt: C8263) Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_0007 (U-937) |
Sex of cell |
Male |
Age at sampling |
37Y |
Category |
Cancer cell line |
Publications | PubMed=3313729; DOI=10.1126/science.3313729 Thomas M. Folks, Jesse Shawn Justement, Audrey L. Kinter, Charles Anthony Dinarello, Anthony Stephen Fauci; Cytokine-induced expression of HIV-1 in a chronically infected promonocyte cell line. Science 238:800-802(1987) PubMed=2449497; DOI=10.4049/jimmunol.140.4.1117 Thomas M. Folks, Jesse Shawn Justement, Audrey L. Kinter, Steven Schnittman, Jan Marc Orenstein, Guido Poli, Anthony Stephen Fauci; Characterization of a promonocyte clone chronically infected with HIV and inducible by 13-phorbol-12-myristate acetate. J. Immunol. 140:1117-1122(1988) PubMed=28086908; DOI=10.1186/s12977-016-0325-2; PMCID=PMC5237276 Jori Symons, Abha Chopra, Eva Malatinkova, Ward De Spiegelaere, Shay Leary, Don Cooper, Chike O. Abana, Ajantha Rhodes, Simin D. Rezaei, Linos Vandekerckhove, Simon Mallal ...Show all 13 authors... , Sharon Ruth Lewin, Paul Urquhart Cameron; Show fewer authors HIV integration sites in latently infected cell lines: evidence of ongoing replication. Retrovirology 14:2.1-2.11(2017) |
Cross-references |
Cell line collections (Providers) |
BEI_Resources; ARP-165
|
Cell line databases/resources |
cancercelllines; CVCL_M769
Lonza; 1169
|
Chemistry resources |
ChEMBL-Cells; CHEMBL3307351
ChEMBL-Targets; CHEMBL614246
PubChem_Cell_line; CVCL_M769
|
Encyclopedic resources |
Wikidata; Q54973623
|
Entry history |
Entry creation | 05-Nov-2013 |
Last entry update | 19-Dec-2024 |
Version number | 24 |
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