Cellosaurus logo
expasy logo

Cellosaurus iLite Type I IFN Assay Ready Cells (CVCL_E7RW)

[Text][XML][JSON]
Cell line name iLite Type I IFN Assay Ready Cells
Accession CVCL_E7RW
Resource Identification Initiative To cite this cell line use: iLite Type I IFN Assay Ready Cells (RRID:CVCL_E7RW)
Comments Population: Caucasian.
Characteristics: Engineered to express firefly Luciferase under the control of an IFN alpha/beta responsive promoter. When IFN alpha or IFN beta binds to the IFN a/b receptor on the cell surface, the IFN a/b regulated firefly luciferase reporter gene construct is activated, resulting in a luminescent signal (Svar Life Science=BM3049).
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Genetic integration: Method=Transfection; Gene=UniProtKB; P08659; Photinus pyralis firefly-type luciferase.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; HGNC:16063; MLLT10 + HGNC; HGNC:15514; PICALM; Name(s)=PICALM-MLLT10, CALM-AF10 (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Gly129fs*51 (c.387_388insCGCC); Zygosity=Hemizygous (from parent cell line).
  • Mutation; HGNC; HGNC:9644; PTPN11; Simple; p.Gly60Arg (c.178G>C); ClinVar=VCV000372590; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; c.559+1G>A (p.Val173Trpfs*59); ClinVar=VCV000428908; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
  • Mutation; HGNC; HGNC:12796; WT1; Simple; p.Arg301Ter (c.901C>T) (p.Arg352Ter, c.1054C>T) (p.Arg374Ter, c.1120C>T); ClinVar=VCV000449416; Zygosity=Heterozygous (from parent cell line).
Disease Adult acute monocytic leukemia (NCIt: C8263)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0007 (U-937)
Sex of cell Male
Age at sampling 37Y
Category Cancer cell line
Web pages Provider; Svar Life Science; BM3049; https://www.svarlifescience.com/products/bm3049
Publications

Patent=US8759091
Christophe Lallemand, Michael G. Tovey;
Gene reporter assay, kit and cells with improved sensitivity and/or specificity for determining the level of an extracellular signal.
Patent number US8759091, 24-Jun-2014

Entry history
Entry creation10-Apr-2025
Last entry update14-Aug-2025
Version number2