• Gene deletion; UniProtKB; Q2MH30; Dhfr; Zygosity=Heterozygous (PubMed=25887056).
  
• Mutation; UniProtKB; Q2MH30; Dhfr; Simple; p.Thr137Arg (c.410G>C); Zygosity=Heterozygous (PubMed=25887056).
  

PubMed=6933469; DOI=10.1073/pnas.77.7.4216; PMCID=PMC349802
Gail Urlaub, Lawrence A. Chasin;
Isolation of Chinese hamster cell mutants deficient in dihydrofolate reductase activity.
Proc. Natl. Acad. Sci. U.S.A. 77:4216-4220(1980)

PubMed=6287224; DOI=10.1128/mcb.2.1.93-96.1982; PMCID=PMC369757
Lloyd Herbert Graf Jr., Lawrence A. Chasin;
Direct demonstration of genetic alterations at the dihydrofolate reductase locus after gamma irradiation.
Mol. Cell. Biol. 2:93-96(1982)

PubMed=19003404; DOI=10.1023/A:1008052908496; PMCID=PMC3449829
Brian Rasmussen, Ray Davis, James Thomas, Pranhitha Reddy;
Isolation, characterization and recombinant protein expression in Veggie-CHO: a serum-free CHO host cell line.
Cytotechnology 28:31-42(1998)

PubMed=16003777; DOI=10.1002/bit.20511
Katie Fraass Wlaschin, Peter Morin Nissom, Marcela de Leon Gatti, Peh-Fern Ong, Sanny Arleen, Kher-Shing Tan, Anette Rink, Breana Cham, Kathy Tin-Kam Wong, Miranda Gek-Sim Yap, Wei-Shou Hu;
EST sequencing for gene discovery in Chinese hamster ovary cells.
Biotechnol. Bioeng. 91:592-606(2005)

PubMed=21945585; DOI=10.1016/j.jbiotec.2011.09.014
Jennifer Becker, Matthias Hackl, Oliver Rupp, Tobias Jakobi, Jessica Schneider, Rafael Szczepanowski, Thomas Bekel, Nicole Borth, Alexander Goesmann, Johannes Grillari, Christian Kaltschmidt ...Show all 15 authors... , Thomas Noll, Alfred Puhler, Andreas Tauch, Karina Brinkrolf; Show fewer authors
Unraveling the Chinese hamster ovary cell line transcriptome by next-generation sequencing.
J. Biotechnol. 156:227-235(2011)

DOI=10.3390/pr1030296
Florian Maria Wurm;
CHO quasispecies -- implications for manufacturing processes.
Processes 1:296-311(2013)

PubMed=25887056; DOI=10.1186/s12864-015-1391-x; PMCID=PMC4359788
Christian Schroder Kaas, Claus Kristensen, Michael J. Betenbaugh, Mikael Rordam Andersen;
Sequencing the CHO DXB11 genome reveals regional variations in genomic stability and haploidy.
BMC Genomics 16:160.1-160.9(2015)

PubMed=26993211; DOI=10.1016/j.jbiotec.2016.03.022
Gerald Klanert, Vaibhav Jadhav, Vinoth Shanmukam, Andreas Bernhard Diendorfer, Michael Karbiener, Marcel Scheideler, Juan Antonio Hernandez-Bort, Johannes Grillari, Matthias Hackl, Nicole Borth;
A signature of 12 microRNAs is robustly associated with growth rate in a variety of CHO cell lines.
J. Biotechnol. 235:150-161(2016)

DOI=10.3390/pr5020020
Florian Maria Wurm, Maria Joao Wurm;
Cloning of CHO cells, productivity and genetic stability -- a discussion.
Processes 5:20.1-20.13(2017)

PubMed=32619503; DOI=10.1016/j.ymben.2020.06.002
Diana Szeliova, David Erich Ruckerbauer, Sarah Noel Galleguillos, Lars B. Petersen, Klaus Natter, Michael Hanscho, Christina Troyer, Tim Causon, Harald Schoeny, Hanne Bjerre Christensen, Dong-Yup Lee ...Show all 17 authors... , Nathan E. Lewis, Gunda Koellensperger, Stephan Hann, Lars K. Nielsen, Nicole Borth, Jurgen Zanghellini; Show fewer authors
What CHO is made of: variations in the biomass composition of Chinese hamster ovary cell lines.
Metab. Eng. 61:288-300(2020)

PubMed=33596973; DOI=10.1186/s13039-021-00528-3; PMCID=PMC7888135
Victoria I. Turilova, Tatyana S. Goriachaia, Tatiana K. Yakovleva;
Chinese hamster ovary cell line DXB-11: chromosomal instability and karyotype heterogeneity.
Mol. Cytogenet. 14:11.1-11.12(2021)

PubMed=34050613; DOI=10.1002/biot.202100165
Maria Joao Wurm, Florian Maria Wurm;
Naming CHO cells for bio-manufacturing: genome plasticity and variant phenotypes of cell populations in bioreactors question the relevance of old names.
Biotechnol. J. 16:e2100165.1-e2100165.13(2021)