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Cellosaurus CHO-DXB11 (CVCL_1977)

[Text version]

Cell line name CHO-DXB11
Synonyms CHO DXB11; DXB11-CHO; CHO-DUX-B11; CHO (Dux B11); CHO-DUK-XB11; DUK-XB11; CHO-DUKX B11; CHO-DUKXB11; DUKX-B11; DUX B11; DUXB11; DXB-11; DXB11; CHO-DUKX; DUKX-CHO; DUKX; CHO-DHFR -; CHO/dhFr-; CHO/dhfr-; CHO duk-; CHO B11; B11
Accession CVCL_1977
Secondary accession CVCL_9246
Resource Identification Initiative To cite this cell line use: CHO-DXB11 (RRID:CVCL_1977)
Comments Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-9096.
Doubling time: ~20-24 hours (DSMZ).
Omics: Deep RNAseq analysis.
Omics: Genome sequenced.
Omics: miRNA expression profiling.
Derived from sampling site: Ovary.
Species of origin Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (NCBI Taxonomy: 10029)
Hierarchy Parent: CVCL_5A23 (CHO-UKB25)
CVCL_6356 (35.6 )CVCL_4J66 (3M )CVCL_5A28 (4-HS-MYC )
CVCL_6358 (5/9 m a3-18 )CVCL_4586 (5A-HS-MYC )CVCL_5A29 (5B-HS-MYC )
CVCL_5A27 (6A-HS-MYC )CVCL_4582 (6E6 [Hamster mAB-producing] )CVCL_JM03 (B11UVres )
CVCL_4583 (B13-24 )CVCL_6339 (CHO 1-15 500 )CVCL_B0CX (CHO 106.3 AM1 )
CVCL_DC99 (CHO 1beta9, 12.5, clone 36 )CVCL_B0CV (CHO 3-631-436 AM5 )CVCL_B0CW (CHO 3-631-436 AM8 )
CVCL_1Y13 (CHO 92UG21-9 gp120 (Clade D) )CVCL_DD00 (CHO beta2(414)cl.32 )CVCL_9V75 (CHO CD28 )
CVCL_A0GD (CHO dhfr- Clone 20/1 )CVCL_JZ93 (CHO dhfr(-) Bcl2 )CVCL_JZ94 (CHO dhfr(-) E1B-19K )
CVCL_8844 (CHO DP-12 )CVCL_1Y09 (CHO MW959 gp140 (Clade A) )CVCL_IR13 (CHO-13D-35D )
CVCL_C1CN (CHO-DXB11 hGCR SC 12.9 )CVCL_WS56 (CHO-p658-hPRL )CVCL_WS57 (CHO-pEDdc-hPRL )
CVCL_X696 (CHO-SIVmac239 gp130 Clone 3 )CVCL_X695 (CHO-SIVsmH4 gp130 Clone AD5 )CVCL_JX39 (CHO/dhFr-AC-free )
CVCL_6384 (CTLA4 Ig-24 )CVCL_5A31 (F435 )CVCL_3711 (HIIF-D )
CVCL_4587 (LA 3-5 )CVCL_5I79 (ValiScreen human KCNA3 )CVCL_B6FH (Veggie-CHO )
Sex of cell Female
Age at sampling Adult
Category Spontaneously immortalized cell line
Web pages https://en.wikipedia.org/wiki/Chinese_hamster_ovary_cell

PubMed=6933469; DOI=10.1073/pnas.77.7.4216
Urlaub G., Chasin L.A.
Isolation of Chinese hamster cell mutants deficient in dihydrofolate reductase activity.
Proc. Natl. Acad. Sci. U.S.A. 77:4216-4220(1980)

PubMed=6287224; DOI=10.1128/mcb.2.1.93-96.1982
Graf L.H. Jr., Chasin L.A.
Direct demonstration of genetic alterations at the dihydrofolate reductase locus after gamma irradiation.
Mol. Cell. Biol. 2:93-96(1982)

PubMed=19003404; DOI=10.1023/A:1008052908496
Rasmussen B., Davis R., Thomas J., Reddy P.
Isolation, characterization and recombinant protein expression in Veggie-CHO: A serum-free CHO host cell line.
Cytotechnology 28:31-42(1998)

PubMed=21945585; DOI=10.1016/j.jbiotec.2011.09.014
Becker J., Hackl M., Rupp O., Jakobi T., Schneider J., Szczepanowski R., Bekel T., Borth N., Goesmann A., Grillari J., Kaltschmidt C., Noll T., Puhler A., Tauch A., Brinkrolf K.
Unraveling the Chinese hamster ovary cell line transcriptome by next-generation sequencing.
J. Biotechnol. 156:227-235(2011)

Wurm F.M.
CHO quasispecies -- implications for manufacturing processes.
Processes 1:296-311(2013)

PubMed=25887056; DOI=10.1186/s12864-015-1391-x
Kaas C.S., Kristensen C., Betenbaugh M.J., Andersen M.R.
Sequencing the CHO DXB11 genome reveals regional variations in genomic stability and haploidy.
BMC Genomics 16:160.1-160.9(2015)

PubMed=26993211; DOI=10.1016/j.jbiotec.2016.03.022
Klanert G., Jadhav V., Shanmukam V., Diendorfer A.B., Karbiener M., Scheideler M., Hernandez-Bort J.A., Grillari J., Hackl M., Borth N.
A signature of 12 microRNAs is robustly associated with growth rate in a variety of CHO cell lines.
J. Biotechnol. 235:150-161(2016)

Wurm F.M., Wurm M.J.
Cloning of CHO cells, productivity and genetic stability -- a discussion.
Processes 5:20.1-20.13(2017)

PubMed=32619503; DOI=10.1016/j.ymben.2020.06.002
Szeliova D., Ruckerbauer D.E., Galleguillos S.N., Petersen L.B., Natter K., Hanscho M., Troyer C., Causon T., Schoeny H., Christensen H.B., Lee D.-Y., Lewis N.E., Koellensperger G., Hann S., Nielsen L.K., Borth N., Zanghellini J.
What CHO is made of: variations in the biomass composition of Chinese hamster ovary cell lines.
Metab. Eng. 61:288-300(2020)

PubMed=33596973; DOI=10.1186/s13039-021-00528-3
Turilova V.I., Goryachaya T.S., Yakovleva T.K.
Chinese hamster ovary cell line DXB-11: chromosomal instability and karyotype heterogeneity.
Mol. Cytogenet. 14:11.1-11.12(2021)

Cell line collections ATCC; CRL-9096
BCRC; 60133
BCRJ; 0068
ECACC; 94060607
KCB; KCB 200712YJ
NCBI_Iran; C590
Cell line databases/resources CLO; CLO_0002429
CLO; CLO_0002460
CLO; CLO_0002849
CLDB; cl728
CLDB; cl729
CLDB; cl1114
CCRID; 1101HAM-PUMC000003
CCRID; 6101MOU-CERC000112
DSMZCellDive; ACC-126
TOKU-E; 945
Encyclopedic resources Wikidata; Q54812674
Gene expression databases GEO; GSM1968579
GEO; GSM1968580
GEO; GSM1968585
GEO; GSM1968590
GEO; GSM1968586
GEO; GSM1968581
GEO; GSM1968582
GEO; GSM1968587
GEO; GSM1968583
GEO; GSM1968592
GEO; GSM1968584
GEO; GSM1968588
GEO; GSM1968573
GEO; GSM1968574
GEO; GSM1968577
GEO; GSM1968578
Entry history
Entry creation04-Apr-2012
Last entry update23-Jun-2022
Version number27