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Cellosaurus DLD-1 (CVCL_0248)

[Text version]
Cell line name DLD-1
Synonyms DLD 1; DLD1; CoCL3
Accession CVCL_0248
Resource Identification Initiative To cite this cell line use: DLD-1 (RRID:CVCL_0248)
Comments Part of: AstraZeneca Colorectal cell line (AZCL) panel.
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: MD Anderson Cell Lines Project.
Population: Caucasian.
Doubling time: 20 hours (PubMed=427742); 25.27 hours (PubMed=25944804); 33 hours (PubMed=25984343); ~15 hours (CLS=300220); ~48 hours (DSMZ=ACC-278).
Microsatellite instability: Instable (MSI) (PubMed=10674020; PubMed=24042735; PubMed=24755471; PubMed=28683746; PubMed=25926053).
Omics: Genomics; Whole exome sequencing.
Omics: Glycomics; N-glycan profiling.
Omics: Phenotyping; shRNA library screening.
Omics: Proteomics.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Proteomics; PTM; Phosphorylation.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; miRNA profiling; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Misspelling: DLD; Cosmic=1571767; Cosmic=1676737.
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Cell type: Epithelial cell of colon; CL=CL_0011108.
Sequence variations
HLA typing Source: PubMed=25960936
Class I
HLA-AA*02:01,24:02
HLA-BB*08:01,35:01
HLA-CC*04:01,07:01

Source: PubMed=26589293
Class I
HLA-AA*02:01,24:02
HLA-BB*08:01,08:01
HLA-CC*04:01,07:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0.31
East Asian, North0
East Asian, South0.3
South Asian2.26
European, North64.92
European, South32.2
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_3449 (__Parent_cell_line_of_DLD-1/HCT 8/HCT 15/HRT-18)
Children:
CVCL_KV91 (cAMP Hunter DLD1 ADRB3 Gs)CVCL_KV92 (cAMP Hunter DLD1 HTR7D Gs)CVCL_KV93 (cAMP Hunter DLD1 PTGER2 Gs)
CVCL_9798 (DKO-1)CVCL_9799 (DKO-3)CVCL_9800 (DKO-4)
CVCL_9801 (DKs-5)CVCL_9802 (DKs-8)CVCL_HD52 (DLD-1 AKT1(-/-))
CVCL_HD53 (DLD-1 AKT2(-/-))CVCL_A2PQ (DLD-1 AKT3(-/-))CVCL_HD54 (DLD-1 ATG7(+/-))
CVCL_HD55 (DLD-1 BBC3(-/-))CVCL_HD56 (DLD-1 BRCA2(+/-))CVCL_HD57 (DLD-1 BRCA2(-/-))
CVCL_HD58 (DLD-1 CDKN1A(-/-))CVCL_V011 (DLD-1 clone A)CVCL_V012 (DLD-1 clone D)
CVCL_J250 (DLD-1 clone#1-Luc)CVCL_HD59 (DLD-1 DICER1(-/-))CVCL_HD60 (DLD-1 FBXW7(+/-))
CVCL_HD61 (DLD-1 FBXW7(-/-))CVCL_XZ51 (DLD-1 human PDL1)CVCL_HD62 (DLD-1 KRAS(+/-) 1)
CVCL_HE28 (DLD-1 KRAS(+/-) 2)CVCL_D4XI (DLD-1 PIK3CA (E545K/-))CVCL_RQ05 (DLD-1 PIK3CA E545K KO)
CVCL_ZC13 (DLD-1 SIRT1 Het)CVCL_ZC12 (DLD-1 SIRT1 KO)CVCL_HD63 (DLD-1 SLC2A1(-/-))
CVCL_HD64 (DLD-1 USP7(-/-))CVCL_1Y04 (DLD-1/delta-alpha)CVCL_C4RW (DLD1-FX-R)
CVCL_4V49 (DLDSNR6)CVCL_A3YG (HPS0112)CVCL_D6B4 (HyCyte DLD-1 KO-hBRCA2)
CVCL_D6B5 (HyCyte DLD-1 KO-hPDX1)CVCL_E3H4 (HyCyte DLD-1-Luc)CVCL_KZ27 (PathHunter DLD1 FFAR1 beta-arrestin)
CVCL_KZ28 (PathHunter DLD1 HTR6 beta-arrestin)CVCL_KZ29 (PathHunter DLD1 mPTGER4 beta-arrestin)CVCL_KZ30 (PathHunter DLD1 MTNR1A Total GPCR Internalization)
CVCL_QZ54 (RDLD-1)CVCL_AS01 (T-47D-Luc)
Sex of cell Male
Age at sampling 67Y
Category Cancer cell line
STR profile Source(s): AddexBio=C0009007/36; ATCC=CCL-221; CCRID; CLS=300220; DSMZ=ACC-278; ECACC=90102540; JCRB=JCRB9094; KCLB=10221; PubMed=11416159; PubMed=25877200; PubMed=25926053; TKG=TKG 0379

Markers:
AmelogeninX,Y
CSF1PO11,12 (AddexBio=C0009007/36; ATCC=CCL-221; CCRID; DSMZ=ACC-278; ECACC=90102540; JCRB=JCRB9094; KCLB=10221; PubMed=25877200; PubMed=25926053)
12 (CLS=300220; TKG=TKG 0379)
D2S44113,15
D2S133817,25
D3S135817
D5S81813
D6S104311,13
D7S82010,12
D8S117915
D12S39119,22
D13S3178,11
D16S53912,13
D18S5111,17
D19S43314,16
D21S1129,32.2
FGA22
Penta D9,14
Penta E7,14
TH017,9.3
TPOX8,11
vWA18,19

Run an STR similarity search on this cell line
Web pages Info; MCLP; -; https://tcpaportal.org/mclp/
Info; NCI DTP; NCI-60 additional lines; https://dtp.cancer.gov/discovery_development/nci-60/cell_list.htm
Info; Pawefish; -; https://www.cellosaurus.org/pawefish/ColonCellLineDescriptions/DLD-1.html
Provider; Altogen; Xenograft model; https://altogenlabs.com/xenograft-models/colon-cancer-xenograft/dld-1-xenograft-model/
Publications

PubMed=427742
Daniel L. Dexter, James A. Barbosa, Paul Calabresi;
N,N-dimethylformamide-induced alteration of cell culture characteristics and loss of tumorigenicity in cultured human colon carcinoma cells.
Cancer Res. 39:1020-1025(1979)

PubMed=7247963; DOI=10.1016/0006-2952(81)90167-2
Gerald W. Crabtree, Daniel L. Dexter, Johanna D. Stoeckler, Todd M. Savarese, Lucy Y. Ghoda, Timothy L. Rogler-Brown, Paul Calabresi, Robert E. Parks Jr.;
Activities of purine-metabolizing enzymes in human colon carcinoma cell lines and xenograft tumors.
Biochem. Pharmacol. 30:793-798(1981)

PubMed=6652615; DOI=10.1016/0165-4608(83)90092-4
Tchaw-Ren Chen, Robert J. Hay, Marvin L. Macy;
Intercellular karyotypic similarity in near-diploid cell lines of human tumor origins.
Cancer Genet. Cytogenet. 10:351-362(1983)

PubMed=3335022
Michael C. Alley, Dominic A. Scudiero, Anne Monks, Miriam L. Hursey, Maciej J. Czerwinski, Donald L. Fine, Betty Jane Abbott, Joseph G. Mayo, Robert H. Shoemaker, Michael R. Boyd;
Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay.
Cancer Res. 48:589-601(1988)

PubMed=2041050; DOI=10.1093/jnci/83.11.757
Anne Monks, Dominic A. Scudiero, Philip Skehan, Robert H. Shoemaker, Kenneth D. Paull, David T. Vistica, Curtis D. Hose, John Langley, Paul Cronise, Anne Vaigro-Wolff, Marcia Gray-Goodrich ...Show all 14 authors... , Hugh Campbell, Joseph G. Mayo, Michael R. Boyd; Show fewer authors
Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines.
J. Natl. Cancer Inst. 83:757-766(1991)

PubMed=8422623; DOI=10.1002/1097-0142(19930115)71:2<315::AID-CNCR2820710208>3.0.CO;2-B
Lance M. Tibbetts, Craig M. Doremus, George N. Tzanakakis, Michael P. Vezeridis;
Liver metastases with 10 human colon carcinoma cell lines in nude mice and association with carcinoembryonic antigen production.
Cancer 71:315-321(1993)

PubMed=8464898; DOI=10.1073/pnas.90.7.2842; PMCID=PMC46192
Michael J. Browning, Peter Krausa, Andrew J. Rowan, David C. Bicknell, Julia Gwynaeth Bodmer, Walter Fred Bodmer;
Tissue typing the HLA-A locus from genomic DNA by sequence-specific PCR: comparison of HLA genotype and surface expression on colorectal tumor cell lines.
Proc. Natl. Acad. Sci. U.S.A. 90:2842-2845(1993)

PubMed=7874267; DOI=10.1007/BF02349278
Shigeo Ikuta, Fumio Itoh, Yuji Hinoda, Minoru Toyota, Yusuke Makiguchi, Kohzoh Imai, Akira Yachi;
Expression of cytoskeletal-associated protein tyrosine phosphatase PTPH1 mRNA in human hepatocellular carcinoma.
J. Gastroenterol. 29:727-732(1994)

PubMed=7972006; DOI=10.1073/pnas.91.23.11045; PMCID=PMC45163
Aikou Okamoto, Douglas J. Demetrick, Elisa A. Spillare, Koichi Hagiwara, S. Perwez Hussain, William P. Bennett, Kathleen Forrester, Brenda Isen Gerwin, Manuel Serrano, David H. Beach, Curtis Craig Harris;
Mutations and altered expression of p16INK4 in human cancer.
Proc. Natl. Acad. Sci. U.S.A. 91:11045-11049(1994)

PubMed=8197130; DOI=10.1073/pnas.91.11.4751; PMCID=PMC43866
David C. Bicknell, Andrew J. Rowan, Walter Fred Bodmer;
Beta 2-microglobulin gene mutations: a study of established colorectal cell lines and fresh tumors.
Proc. Natl. Acad. Sci. U.S.A. 91:4751-4755(1994)

PubMed=7621404; DOI=10.1016/0165-4608(94)00225-z
Tchaw-Ren Chen, Catherine S. Dorotinsky, Linda J. McGuire, Marvin L. Macy, Robert J. Hay;
DLD-1 and HCT-15 cell lines derived separately from colorectal carcinomas have totally different chromosome changes but the same genetic origin.
Cancer Genet. Cytogenet. 81:103-108(1995)

PubMed=7651727
William Vasilios Kastrinakis, Nirasha Ramchurren, Karen M. Rieger, Donald T. Hess, Massimo Loda, Glenn Steele, Ian C. Summerhayes;
Increased incidence of p53 mutations is associated with hepatic metastasis in colorectal neoplastic progression.
Oncogene 11:647-652(1995)

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Li-Qun Jia, Motonobu Osada, Chikashi Ishioka, Makio Gamo, Shuntaro Ikawa, Takao Suzuki, Hideki Shimodaira, Tomohito Niitani, Toshio Kudo, Mitoshi Akiyama, Narimiti Kimura ...Show all 18 authors... , Mitsuyoshi Matsuo, Hiroshi Mizusawa, Noriho Tanaka, Hideki Koyama, Masayoshi Namba, Ryunosuke Kanamaru, Toshio Kuroki; Show fewer authors
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

PubMed=9294210; DOI=10.1073/pnas.94.19.10330; PMCID=PMC23362
Mohammad Ilyas, Ian Philip Mark Tomlinson, Andrew J. Rowan, Massimo Pignatelli, Walter Fred Bodmer;
Beta-catenin mutations in cell lines established from human colorectal cancers.
Proc. Natl. Acad. Sci. U.S.A. 94:10330-10334(1997)

PubMed=9515795
Andrew B. Sparks, Patrice J. Morin, Bert Vogelstein, Kenneth Wayne Kinzler;
Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer.
Cancer Res. 58:1130-1134(1998)

PubMed=9809040; DOI=10.1016/S0165-4608(98)00081-8
Stefan Joris Vermeulen, Tchaw-Ren Chen, Frank Speleman, Friedel Nollet, Frans M. Van Roy, Marc M. Mareel;
Did the four human cancer cell lines DLD-1, HCT-15, HCT-8, and HRT-18 originate from one and the same patient?
Cancer Genet. Cytogenet. 107:76-79(1998)

PubMed=10674020; DOI=10.1016/S0959-8049(99)00206-3
Ja-Lok Ku, Kyong-Ah Yoon, D.-Y. Kim, Jae-Gahb Park;
Mutations in hMSH6 alone are not sufficient to cause the microsatellite instability in colorectal cancer cell lines.
Eur. J. Cancer 35:1724-1729(1999)

PubMed=10612807; DOI=10.1002/(SICI)1098-2264(200002)27:2<183::AID-GCC10>3.0.CO;2-P; PMCID=PMC4721570
B. Michael Ghadimi, Dan L. Sackett, Michael J. Difilippantonio, Evelin Schrock, Thomas Neumann, Annukka Jauho, Gert Auer, Thomas Ried;
Centrosome amplification and instability occurs exclusively in aneuploid, but not in diploid colorectal cancer cell lines, and correlates with numerical chromosomal aberrations.
Genes Chromosomes Cancer 27:183-190(2000)

PubMed=10700188; DOI=10.1038/73536
Simon Andrew Gayther, Sarah J. Batley, Lori Linger, Andrew J. Bannister, Karen Thorpe, Suet-Feung Chin, Yataro Daigo, Paul Russell, Annie Wilson, Heidi M. Sowter, Joy Dorothy Ann Delhanty ...Show all 14 authors... , Bruce Anthony John Ponder, Tony Kouzarides, Carlos Caldas; Show fewer authors
Mutations truncating the EP300 acetylase in human cancers.
Nat. Genet. 24:300-303(2000)

PubMed=11226274; DOI=10.1073/pnas.041603298; PMCID=PMC30173
Wael M. Abdel-Rahman, Kanade Katsura, Willem Rens, Patricia A. Gorman, Denise Sheer, David C. Bicknell, Walter Fred Bodmer, Mark J. Arends, Andrew Hamilton Wyllie, Paul A.W. Edwards;
Spectral karyotyping suggests additional subsets of colorectal cancers characterized by pattern of chromosome rearrangement.
Proc. Natl. Acad. Sci. U.S.A. 98:2538-2543(2001)

PubMed=11414198; DOI=10.1007/s004320000207
Harald Lahm, Sabine Andre, Andreas Hoeflich, Jurgen R. Fischer, Bernard Sordat, Herbert Kaltner, Eckhard Wolf, Hans-Joachim Gabius;
Comprehensive galectin fingerprinting in a panel of 61 human tumor cell lines by RT-PCR and its implications for diagnostic and therapeutic procedures.
J. Cancer Res. Clin. Oncol. 127:375-386(2001)

PubMed=11416159; DOI=10.1073/pnas.121616198; PMCID=PMC35459
John R.W. Masters, Jim A. Thomson, Bernadette Daly-Burns, Yvonne A. Reid, Wilhelm Gerhard Dirks, Phil Packer, Lorraine H. Toji, Tadao Ohno, Hideyuki Tanabe, Colin Francis Arlett, Lloyd R. Kelland ...Show all 16 authors... , Maureen Harrison, Arvind K. Virmani, Timothy H. Ward, Karen L. Ayres, Paul G. Debenham; Show fewer authors
Short tandem repeat profiling provides an international reference standard for human cell lines.
Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001)

PubMed=11668190; DOI=10.1177/002215540104901105
Hilmar Quentmeier, Mary Osborn, Julia Reinhardt, Margarete Zaborski, Hans Gunther Drexler;
Immunocytochemical analysis of cell lines derived from solid tumors.
J. Histochem. Cytochem. 49:1369-1378(2001)

PubMed=12068308; DOI=10.1038/nature00766
Helen R. Davies, Graham Robert Bignell, Charles Cox, Philip J. Stephens, Sarah Edkins, Sheila Clegg, Jon W. Teague, Hayley Woffendin, Mathew J. Garnett, William Bottomley, Neil Davis ...Show all 52 authors... , Ed Dicks, Rebecca Ewing, Yvonne Floyd, Kristian Gray, Sarah Hall, Rachel Hawes, Jaime Hughes, Vivian Kosmidou, Andrew Menzies, Catherine Mould, Adrian Parker, Claire Stevens, Stephen Watt, Steven Hooper, Rebecca Wilson, Hiran Jayatilake, Barry Austin Gusterson, Colin S. Cooper, Janet M. Shipley, Darren Hargrave, Kathy Pritchard-Jones, Norman J. Maitland, Georgia Chenevix-Trench, Gregory J. Riggins, Darell Doty Bigner, Giuseppe Palmieri, Antonio Cossu, Adrienne M. Flanagan, Andrew Nicholson, Judy W.C. Ho, Suet Yi Leung, Siu Tsan Yuen, Barbara L. Weber, Hilliard Foster Seigler, Timothy L. Darrow, Hugh F. Paterson, Richard Marais, Christopher John Marshall, Richard Wooster, Michael Rudolf Stratton, P. Andrew Futreal; Show fewer authors
Mutations of the BRAF gene in human cancer.
Nature 417:949-954(2002)

PubMed=12615714
Paula M. Hempen, Lin Zhang, Ravi K. Bansal, Christine A. Iacobuzio-Donahue, Kathleen M. Murphy, Anirban Maitra, Bert Vogelstein, Robert H. Whitehead, Sanford David Markowitz, James K.V. Willson, Charles J. Yeo ...Show all 13 authors... , Ralph H. Hruban, Scott E. Kern; Show fewer authors
Evidence of selection for clones having genetic inactivation of the activin A type II receptor (ACVR2) gene in gastrointestinal cancers.
Cancer Res. 63:994-999(2003)

PubMed=16418264; DOI=10.1073/pnas.0510146103; PMCID=PMC1327731
Ying Liu, Walter Fred Bodmer;
Analysis of p53 mutations and their expression in 56 colorectal cancer cell lines.
Proc. Natl. Acad. Sci. U.S.A. 103:976-981(2006)

PubMed=16854228; DOI=10.1186/1476-4598-5-29; PMCID=PMC1550420
Eva Maria Bandres Elizalde, Elena Cubedo, Xabier Agirre, Raquel Malumbres, Ruth Zarate, Natalia Ramirez, Ana Abajo, Alfons Navarro, Isabel Moreno, Mariano Monzo, Jesus Garcia-Foncillas;
Identification by real-time PCR of 13 mature microRNAs differentially expressed in colorectal cancer and non-tumoral tissues.
Mol. Cancer 5:29.1-29.10(2006)

PubMed=18258742; DOI=10.1073/pnas.0712176105; PMCID=PMC2268141
Muhammad Emaduddin, David C. Bicknell, Walter Fred Bodmer, Stephan M. Feller;
Cell growth, global phosphotyrosine elevation, and c-Met phosphorylation through Src family kinases in colorectal cancer cells.
Proc. Natl. Acad. Sci. U.S.A. 105:2358-2362(2008)

PubMed=19927377; DOI=10.1002/gcc.20730; PMCID=PMC2818350
Turid Knutsen, Hesed Maria Padilla-Nash, Danny Wangsa, Linda Barenboim-Stapleton, Jordi Camps, Nicole E. McNeil, Michael J. Difilippantonio, Thomas Ried;
Definitive molecular cytogenetic characterization of 15 colorectal cancer cell lines.
Genes Chromosomes Cancer 49:204-223(2010)

PubMed=20570890; DOI=10.1158/0008-5472.CAN-10-0192; PMCID=PMC2943514
Manickam Janakiraman, Efsevia Vakiani, Zhao-Shi Zeng, Christine A. Pratilas, Barry Stephen Taylor, Dhananjay Chitale, Ensar Halilovic, Manda Wilson, Kety Huberman, Julio Cezar Marques Ricarte Filho, Yogindra Persaud ...Show all 21 authors... , Douglas A. Levine, James Alexander Fagin, Suresh C. Jhanwar, John M. Mariadason, Alex Lash, Marc Ladanyi, Leonard B. Saltz, Adriana Heguy, Philip B. Paty, David B. Solit; Show fewer authors
Genomic and biological characterization of exon 4 KRAS mutations in human cancer.
Cancer Res. 70:5901-5911(2010)

PubMed=20606684; DOI=10.1038/sj.bjc.6605780; PMCID=PMC2920028
Karin Bracht, Angela M. Nicholls, Ying Liu, Walter Fred Bodmer;
5-fluorouracil response in a large panel of colorectal cancer cell lines is associated with mismatch repair deficiency.
Br. J. Cancer 103:340-346(2010)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=22490663; DOI=10.1016/j.bbrc.2012.03.122
Yuriko Saiki, Yuki Yoshino, Hiroko Fujimura, Tatsuya Manabe, Yuki Kudo, Miki Shimada, Nariyasu Mano, Tomohiro Nakano, Yoonha Lee, Shinjiro Shimizu, Shinya Oba ...Show all 23 authors... , Sho Fujiwara, Hideyuki Shimizu, Na Chen, Zhaleh Kashkouli Nezhad, Guo Jin, Shinichi Fukushige, Makoto Sunamura, Masaharu Ishida, Fuyuhiko Motoi, Shinichi Egawa, Michiaki Unno, Akira Horii; Show fewer authors
DCK is frequently inactivated in acquired gemcitabine-resistant human cancer cells.
Biochem. Biophys. Res. Commun. 421:98-104(2012)

PubMed=23272949; DOI=10.1186/1755-8794-5-66; PMCID=PMC3543849
Andreas Schlicker, Garry Beran, Christine M. Chresta, Gael McWalter, Alison Pritchard, Susie Weston, Sarah Runswick, Sara Davenport, Kerry Heathcote, Denis Alferez Castro, George Orphanides ...Show all 13 authors... , Tim French, Lodewyk F.A. Wessels; Show fewer authors
Subtypes of primary colorectal tumors correlate with response to targeted treatment in colorectal cell lines.
BMC Med. Genomics 5:66.1-66.15(2012)

PubMed=24042735; DOI=10.1038/oncsis.2013.35; PMCID=PMC3816225
Deeqa Ahmed, Peter W. Eide, Ina A. Eilertsen, Stine A. Danielsen, Mette Eknaes, Merete Hektoen, Guro Elisabeth Lind, Ragnhild Adelheid Lothe;
Epigenetic and genetic features of 24 colon cancer cell lines.
Oncogenesis 2:e71.1-e71.8(2013)

PubMed=24755471; DOI=10.1158/0008-5472.CAN-14-0013
Dmitri Mouradov, Clare Sloggett, Robert N. Jorissen, Christopher G. Love, Shan Li, Antony Wilks Burgess, Diego Arango, Robert L. Strausberg, Daniel Buchanan, Samuel Wormald, Liam O'Connor ...Show all 17 authors... , Jennifer L. Wilding, David C. Bicknell, Ian Philip Mark Tomlinson, Walter Fred Bodmer, John M. Mariadason, Oliver M. Sieber; Show fewer authors
Colorectal cancer cell lines are representative models of the main molecular subtypes of primary cancer.
Cancer Res. 74:3238-3247(2014)

PubMed=25960936; DOI=10.4161/21624011.2014.954893; PMCID=PMC4355981
Sebastian Boegel, Martin Lower, Thomas Bukur, Ugur Sahin, John C. Castle;
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
OncoImmunology 3:e954893.1-e954893.12(2014)

PubMed=25984343; DOI=10.1038/sdata.2014.35; PMCID=PMC4432652
Glenn S. Cowley, Barbara A. Weir, Francisca Vazquez, Pablo Tamayo, Justine A. Scott, Scott Rusin, Alexandra East-Seletsky, Levi D. Ali, William F.J. Gerath, Sarah E. Pantel, Patrick Hall Lizotte ...Show all 40 authors... , Guo-Zhi Jiang, Jessica Hsiao, Aviad Tsherniak, Elizabeth Dwinell, Simon Aoyama, Michael Okamoto, William Harrington, Ellen T. Gelfand, Thomas M. Green, Mark J. Tomko, Shuba Gopal, Terence C. Wong, Hu-Bo Li, Sara Howell, Nicolas Stransky, Ted Liefeld, Dongkeun Jang, Jonathan Bistline, Barbara Hill Meyers, Scott Allen Armstrong, Kenneth Carl Anderson, Kimberly Stegmaier, Michael Reich, David Pellman, Jesse S. Boehm, Jill P. Mesirov, Todd Robert Golub, David E. Root, William Chun Hahn; Show fewer authors
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035.1-140035.12(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Christiaan Klijn, Steffen Durinck, Eric W. Stawiski, Peter M. Haverty, Zhao-Shi Jiang, Han-Bin Liu, Jeremiah Degenhardt, Oleg Mayba, Florian Gnad, Jin-Feng Liu, Gregoire Pau ...Show all 30 authors... , Jens Reeder, Yi Cao, Kiran Mukhyala, Suresh K. Selvaraj, Ma-Mie Yu, Gregory J. Zynda, Matthew J. Brauer, Thomas D. Wu, Robert Clifford Gentleman, Gerard Manning, Robert L. Yauch, Richard Bourgon, David Stokoe, Zora Modrusan, Richard M. Neve, Frederic J. de Sauvage, Jeffrey Settleman, Somasekar Seshagiri, Ze-Min Zhang; Show fewer authors
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25841592; DOI=10.1016/j.jprot.2015.03.019
Sander R. Piersma, Jaco C. Knol, Inge de Reus, Mariette Labots, Bharath K. Sampadi, Thang V. Pham, Yasushi Ishihama, Henk M.W. Verheul, Connie R. Jimenez;
Feasibility of label-free phosphoproteomics and application to base-line signaling of colorectal cancer cell lines.
J. Proteomics 127:247-258(2015)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=25926053; DOI=10.1038/ncomms8002
Enzo Medico, Mariangela Russo, Gabriele Picco, Carlotta Cancelliere, Emanuele Valtorta, Giorgio Corti, Michela Buscarino, Claudio Isella, Simona Lamba, Barbara Martinoglio, Silvio Veronese ...Show all 19 authors... , Salvatore Siena, Andrea Sartore-Bianchi, Marco Beccuti, Marcella Mottolese, Michael Linnebacher, Francesca Cordero, Federica Di Nicolantonio, Alberto Bardelli; Show fewer authors
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Sarah Bazzocco, Higinio Dopeso, Fernando Carton-Garcia, Irati Macaya, Elena Andretta, Fiona Chionh, Paulo Rodrigues, Miriam Garrido, Hafid Alazzouzi, Rocio Nieto, Alex Sanchez ...Show all 15 authors... , Simo Schwartz Jr., Josipa Bilic, John M. Mariadason, Diego Arango; Show fewer authors
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Prasanna Vidyasekar, Pavithra Shyamsunder, Rajpranap Arun, Rajalakshmi Santhakumar, Nand Kishore Kapadia, Ravi Kumar, Rama Shanker Verma;
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Noritaka Tanaka, Tetsuo Mashima, Anna Mizutani, Ayana Sato, Aki Aoyama, Bo Gong, Haruka Yoshida, Yukiko Muramatsu, Kento Nakata, Masaaki Matsuura, Ryohei Katayama ...Show all 15 authors... , Satoshi Nagayama, Naoya Fujita, Yoshikazu Sugimoto, Hiroyuki Seimiya; Show fewer authors
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Cross-references
Cell line collections (Providers) AddexBio; C0009007/36
ATCC; CCL-221
BCRC; 60132
CLS; 300220
DSMZ; ACC-278
ECACC; 90102540
ICLC; HTL95011
JCRB; JCRB9094
KCB; KCB 2011096YJ
KCLB; 10221
RCB; RCB1957 - Discontinued
TKG; TKG 0379
Cell line databases/resources CLO; CLO_0002785
MCCL; MCC:0000138
CLDB; cl1065
CLDB; cl1066
cancercelllines; CVCL_0248
CCRID; 1101HUM-PUMC000671
CCRID; 3101HUMTCHu134
CCRID; 4201HUM-CCTCC00620
Cell_Model_Passport; SIDM00787
ColonAtlas; DLD1
DepMap; ACH-001061
DSMZCellDive; ACC-278
LINCS_LDP; LCL-1175
Lonza; 806
SKY/M-FISH/CGH; 1992
SKY/M-FISH/CGH; 2763
TOKU-E; 1078
Anatomy/cell type resources BTO; BTO_0000391
Biological sample resources BioSample; SAMN01821551
BioSample; SAMN01821680
BioSample; SAMN03472323
ENCODE; ENCBS580BTU
ENCODE; ENCBS621AWM
CRISP screens repositories BioGRID_ORCS_Cell_line; 158
Chemistry resources ChEMBL-Cells; CHEMBL3307580
ChEMBL-Targets; CHEMBL614285
PharmacoDB; DLD1_294_2019
PubChem_Cell_line; CVCL_0248
Encyclopedic resources Wikidata; Q54831148
Experimental variables resources EFO; EFO_0006389
Gene expression databases ArrayExpress; E-MTAB-2706
GEO; GSM206467
GEO; GSM274715
GEO; GSM274716
GEO; GSM274727
GEO; GSM513817
GEO; GSM514291
GEO; GSM741247
GEO; GSM886979
GEO; GSM888048
GEO; GSM1346869
GEO; GSM1374463
GEO; GSM1448161
GEO; GSM1696579
GEO; GSM1696580
GEO; GSM1696581
GEO; GSM1696582
GEO; GSM2549997
Metabolomic databases MetaboLights; MTBLS227
Polymorphism and mutation databases Cosmic; 687519
Cosmic; 755307
Cosmic; 870451
Cosmic; 873699
Cosmic; 876713
Cosmic; 905005
Cosmic; 913890
Cosmic; 934560
Cosmic; 948123
Cosmic; 983737
Cosmic; 985994
Cosmic; 1043810
Cosmic; 1066204
Cosmic; 1122323
Cosmic; 1154643
Cosmic; 1175839
Cosmic; 1184082
Cosmic; 1184331
Cosmic; 1187305
Cosmic; 1223137
Cosmic; 1310949
Cosmic; 1466813
Cosmic; 1479591
Cosmic; 1481418
Cosmic; 1519360
Cosmic; 1524004
Cosmic; 1552176
Cosmic; 1571767
Cosmic; 1609511
Cosmic; 1676737
Cosmic; 1805251
Cosmic; 2301544
Cosmic; 2301972
Cosmic; 2389573
Cosmic; 2464668
Cosmic; 2550352
Cosmic; 2646769
Cosmic; 2650774
Cosmic; 2651870
Cosmic; 2664050
Cosmic; 2667971
Cosmic; 2668249
Cosmic; 2727471
Cosmic; 2727478
Cosmic; 2760067
Cosmic; 2787544
Cosmic; 2811050
IARC_TP53; 18
Progenetix; CVCL_0248
Proteomic databases PRIDE; PXD000218
PRIDE; PXD001550
PRIDE; PXD005354
PRIDE; PXD005355
Sequence databases EGA; EGAS00001000610
EGA; EGAS00001002554
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number48