Cellosaurus cell line DLD-1 AKT2(-/-) (CVCL

Cellosaurus DLD-1 AKT2(-/-) (CVCL_HD53)

Cross-references
Cell line name	DLD-1 AKT2(-/-)
Synonyms	AKT2 (-/-) DLD-1
Accession	CVCL_HD53
Resource Identification Initiative	To cite this cell line use: DLD-1 AKT2(-/-) (RRID:CVCL_HD53)
Comments	Population: Caucasian. Knockout cell: Method=Homologous recombination; HGNC; HGNC:392; AKT2. Derived from site: In situ; Colon; UBERON=UBERON_0001155. Cell type: Epithelial cell of colon; CL=CL_0011108.
Disease	Colon adenocarcinoma (NCIt: C4349)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0248 (DLD-1)
Sex of cell	Male
Age at sampling	67Y
Category	Cancer cell line
Publications	PubMed=20133737; DOI=10.1073/pnas.0914018107; PMCID=PMC2823889 Kajsa Ericson, Christine Gan, Ian Cheong, Carlo Rago, Yardena Samuels, Victor E. Velculescu, Kenneth Wayne Kinzler, David L. Huso, Bert Vogelstein, Nickolas Papadopoulos; Genetic inactivation of AKT1, AKT2, and PDPK1 in human colorectal cancer cells clarifies their roles in tumor growth regulation. Proc. Natl. Acad. Sci. U.S.A. 107:2598-2603(2010) PubMed=27878243; DOI=10.3892/ijo.2016.3771; PMCID=PMC5182003 Sara Haggblad Sahlberg, Anja C. Mortensen, Jakob Haglof, Mikael Karl Robert Engskog, Torbjorn Arvidsson, Curt Pettersson, Bengt Glimelius, Bo Stenerlow, Marika Nestor; Different functions of AKT1 and AKT2 in molecular pathways, cell migration and metabolism in colon cancer cells. Int. J. Oncol. 50:5-14(2017)
Cell line collections (Providers)	Horizon_Discovery; HD+R00-002
Encyclopedic resources	Wikidata; Q54831150
Entry history
Entry creation	01-Dec-2016
Last entry update	19-Dec-2024
Version number	7