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Cellosaurus DLD-1 PIK3CA E545K KO (CVCL_RQ05)

[Text version]
Cell line name DLD-1 PIK3CA E545K KO
Synonyms PIK3CA^(+/-) DLD-1
Accession CVCL_RQ05
Resource Identification Initiative To cite this cell line use: DLD-1 PIK3CA E545K KO (RRID:CVCL_RQ05)
Comments Population: Caucasian.
Characteristics: In DLD-1 one of the two PIK3CA alleles has a p.Glu545Lys mutation. This cell line is KO for the mutant allele (PubMed=15950905).
Knockout cell: Method=Recombinant Adeno-Associated Virus; HGNC; HGNC:8975; PIK3CA (Note=1 of 2 alleles, that with p.Glu545Lys).
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Cell type: Epithelial cell of colon; CL=CL_0011108.
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0248 (DLD-1)
Sex of cell Male
Age at sampling 67Y
Category Cancer cell line
Publications

PubMed=15950905; DOI=10.1016/j.ccr.2005.05.014
Yardena Samuels, Luis Alberto Diaz Jr., Oleg Schmidt-Kittler, Jordan Matthew Cummins, Laura DeLong, Ian Cheong, Carlo Rago, David L. Huso, Christoph Lengauer, Kenneth Wayne Kinzler, Bert Vogelstein, Victor E. Velculescu;
Mutant PIK3CA promotes cell growth and invasion of human cancer cells.
Cancer Cell 7:561-573(2005)

Cross-references
Cell line collections (Providers) Horizon_Discovery; HD+105-001
Encyclopedic resources Wikidata; Q54831164
Entry history
Entry creation05-Mar-2018
Last entry update19-Dec-2024
Version number8