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Cellosaurus DLD-1 SIRT1 KO (CVCL_ZC12)

[Text version]
Cell line name DLD-1 SIRT1 KO
Synonyms DLD1 SIRT1 KO; SIRT1 KO DLD1
Accession CVCL_ZC12
Resource Identification Initiative To cite this cell line use: DLD-1 SIRT1 KO (RRID:CVCL_ZC12)
Comments Population: Caucasian.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:14929; SIRT1.
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Cell type: Epithelial cell of colon; CL=CL_0011108.
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0248 (DLD-1)
Sex of cell Male
Age at sampling 67Y
Category Cancer cell line
Publications

PubMed=28162896; DOI=10.1016/j.cub.2016.12.047; PMCID=PMC5319916
Natalie S.-X. Ren, Ming Ji, Erik J. Tokar, Evan L. Busch, Xiao-Jiang Xu, DeAsia Lewis, Xiang-Chun Li, Ai-Wen Jin, Yan-Ping Zhang, William K.-K. Wu, Wei-Chun Huang ...Show all 16 authors... , Le-Ping Li, David C. Fargo, Temitope O. Keku, Robert S. Sandler, Xiao-Ling Li; Show fewer authors
Haploinsufficiency of SIRT1 enhances glutamine metabolism and promotes cancer development.
Curr. Biol. 27:483-494(2017)

Cross-references
Cell line collections (Providers) Kerafast; ENH130-FP
Encyclopedic resources Wikidata; Q98125876
Entry history
Entry creation02-Jul-2020
Last entry update19-Dec-2024
Version number6