• Mutation; HGNC; 11998; TP53; Simple; p.His179Tyr (c.535C>T); ClinVar=VCV000127815; Zygosity=Heterozygous (PubMed=8504475).
  
• Mutation; HGNC; 11998; TP53; Simple; p.Arg282Trp (c.843_844CC>TT); Zygosity=Heterozygous (PubMed=8504475).
  

PubMed=2450098; DOI=10.1083/jcb.106.3.761
Boukamp P., Dzarlieva-Petrusevska R.T., Breitkreutz D., Hornung J., Markham A.F., Fusenig N.E.
Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line.
J. Cell Biol. 106:761-771(1988)

PubMed=8162337; DOI=10.1111/j.1600-0625.1993.tb00030.x
Schurer N., Kohne A., Schliep V., Barlag K., Goerz G.
Lipid composition and synthesis of HaCaT cells, an immortalized human keratinocyte line, in comparison with normal human adult keratinocytes.
Exp. Dermatol. 2:179-185(1993)

PubMed=8504475; DOI=10.1093/carcin/14.5.833
Lehman T.A., Modali R., Boukamp P., Stanek J., Bennett W.P., Welsh J.A., Metcalf R.A., Stampfer M.R., Fusenig N.E., Rogan E.M., Harris C.C.
p53 mutations in human immortalized epithelial cell lines.
Carcinogenesis 14:833-839(1993)

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Jia L.-Q., Osada M., Ishioka C., Gamo M., Ikawa S., Suzuki T., Shimodaira H., Niitani T., Kudo T., Akiyama M., Kimura N., Matsuo M., Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

PubMed=9406811; DOI=10.1111/1523-1747.ep12340708
Henseleit U., Zhang J., Wanner R., Haase I., Kolde G., Rosenbach T.
Role of p53 in UVB-induced apoptosis in human HaCaT keratinocytes.
J. Invest. Dermatol. 109:722-727(1997)

PubMed=10350023; DOI=10.1023/A:1011945212831
Altenburger R., Kissel T.
The human keratinocyte cell line HaCaT: an in vitro cell culture model for keratinocyte testosterone metabolism.
Pharm. Res. 16:766-771(1999)

PubMed=10523843; DOI=10.1038/sj.onc.1202934
Boukamp P., Popp S., Bleuel K., Tomakidi E., Burkle A., Fusenig N.E.
Tumorigenic conversion of immortal human skin keratinocytes (HaCaT) by elevated temperature.
Oncogene 18:5638-5645(1999)

PubMed=11416159; DOI=10.1073/pnas.121616198
Masters J.R.W., Thomson J.A., Daly-Burns B., Reid Y.A., Dirks W.G., Packer P., Toji L.H., Ohno T., Tanabe H., Arlett C.F., Kelland L.R., Harrison M., Virmani A.K., Ward T.H., Ayres K.L., Debenham P.G.
Short tandem repeat profiling provides an international reference standard for human cell lines.
Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001)

PubMed=11583982; DOI=10.1016/S0002-9440(10)62541-2
Mueller M.M., Peter W., Mappes M., Huelsen A., Steinbauer H., Boukamp P., Vaccariello M.A., Garlick J.A., Fusenig N.E.
Tumor progression of skin carcinoma cells in vivo promoted by clonal selection, mutagenesis, and autocrine growth regulation by granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor.
Am. J. Pathol. 159:1567-1579(2001)

PubMed=15389883; DOI=10.1002/jcb.20212
Lemaitre G., Lamartine J., Pitaval A., Vaigot P., Garin J., Bouet S., Petat C., Soularue P., Gidrol X., Martin M.T., Waksman G.
Expression profiling of genes and proteins in HaCaT keratinocytes: proliferating versus differentiated state.
J. Cell. Biochem. 93:1048-1062(2004)

PubMed=20097197; DOI=10.1016/j.yexcr.2010.01.020
Rasanen K., Vaheri A.
Proliferation and motility of HaCaT keratinocyte derivatives is enhanced by fibroblast nemosis.
Exp. Cell Res. 316:1739-1747(2010)

PubMed=20100199; DOI=10.1111/j.1600-0625.2009.01026.x
Olaru F., Jensen L.E.
Chemokine expression by human keratinocyte cell lines after activation of Toll-like receptors.
Exp. Dermatol. 19:e314-e316(2010)

PubMed=21269460; DOI=10.1186/1752-0509-5-17
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol. 5:17.1-17.13(2011)

PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690
Zhao M., Sano D., Pickering C.R., Jasser S.A., Henderson Y.C., Clayman G.L., Sturgis E.M., Ow T.J., Lotan R., Carey T.E., Sacks P.G., Grandis J.R., Sidransky D., Heldin N.-E., Myers J.N.
Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.
Clin. Cancer Res. 17:7248-7264(2011)

PubMed=24155234; DOI=10.1007/7651_2013_42
Wilson V.G.
Growth and differentiation of HaCaT keratinocytes.
Methods Mol. Biol. 1195:33-41(2014)

PubMed=21185708; DOI=10.1016/j.jnutbio.2010.08.004
Serini S., Donato V., Piccioni E., Trombino S., Monego G., Toesca A., Innocenti I., Missori M., De Spirito M., Celleno L., Fasano E., Ranelletti F.O., Calviello G.
Docosahexaenoic acid reverts resistance to UV-induced apoptosis in human keratinocytes: involvement of COX-2 and HuR.
J. Nutr. Biochem. 22:874-885(2016)

PubMed=26989177; DOI=10.1242/dev.133728
Elbediwy A., Vincent-Mistiaen Z.I., Spencer-Dene B., Stone R.K., Boeing S., Wculek S.K., Cordero J., Tan E.H., Ridgway R., Brunton V.G., Sahai E., Gerhardt H., Behrens A., Malanchi I., Sansom O.J., Thompson B.J.
Integrin signalling regulates YAP and TAZ to control skin homeostasis.
Development 143:1674-1687(2016)

PubMed=29468137; DOI=10.5501/wjv.v7.i1.10
Himmelsbach K., Hildt E.
Identification of various cell culture models for the study of Zika virus.
World J. Virol. 7:10-20(2018)

PubMed=29660373; DOI=10.1016/j.bbagen.2018.04.012
Touat-Hamici Z., Bulteau A.-L., Bianga J., Jean-Jacques H., Szpunar J., Lobinski R., Chavatte L.
Selenium-regulated hierarchy of human selenoproteome in cancerous and immortalized cells lines.
Biochim. Biophys. Acta 1862:2493-2505(2018)

PubMed=31629070; DOI=10.1016/j.tiv.2019.104666
da Silva A.C.G., Chialchia A.R., de Castro E.G., e Silva M.R.L., Arantes D.A.C., Batista A.C., Kitten G.T., Valadares M.C.
A new corneal epithelial biomimetic 3D model for in vitro eye toxicity assessment: development, characterization and applicability.
Toxicol. In Vitro 62:104666.1-104666.7(2019)

PubMed=32938951; DOI=10.1038/s41598-020-71315-0
Pavez Lorie E., Stricker N., Plitta-Michalak B., Chen I.-P., Volkmer B., Greinert R., Jauch A., Boukamp P., Rapp A.
Characterisation of the novel spontaneously immortalized and invasively growing human skin keratinocyte line HaSKpw.
Sci. Rep. 10:15196-15196(2020)

PubMed=33718544; DOI=10.1016/j.dib.2021.106871
Rusanov A.L., Romashin D.D., Zgoda V.G., Butkova T.V., Luzgina N.G.
Protein dataset of immortalized keratinocyte HaCaT cells and normal human keratinocytes.
Data Brief 35:106871.1-106871.6(2021)

PubMed=35072517; DOI=10.1289/EHP9676
Ferragut Cardoso A.P., Banerjee M., Al-Eryani L., Sayed M., Wilkey D.W., Merchant M.L., Park J.W., States J.C.
Temporal modulation of differential alternative splicing in HaCaT human keratinocyte cell line chronically exposed to arsenic for up to 28 wk.
Environ. Health Perspect. 130:17011.1-17011.16(2022)

PubMed=35647242; DOI=10.1016/j.dib.2022.108274
Romashin D.D., Rusanov A.L., Kozhin P.M., Karagyaur M.N., Tikhonova O.V., Zgoda V.G., Luzgina N.G.
Impact of p53 knockdown on protein dataset of HaCaT cells.
Data Brief 42:108274.1-108274.8(2022)