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Cellosaurus HaCaT YAP-5SA (CVCL_QX10)

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Cell line name HaCaT YAP-5SA
Synonyms YAP_5SA_HaCAT
Accession CVCL_QX10
Resource Identification Initiative To cite this cell line use: HaCaT YAP-5SA (RRID:CVCL_QX10)
Comments Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:16262; YAP1 (Note=With p.Ser61Ala, p.Ser109Ala, p.Ser127Ala, p.Ser164Ala and p.Ser381Ala = YAP-5SA).
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Back, skin, epidermis; UBERON=UBERON_0001068+UBERON_0001003.
Cell type: Keratinocyte; CL=CL_0000312.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.His179Tyr (c.535C>T); ClinVar=VCV000127815; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg282Trp (c.843_844CC>TT); Zygosity=Heterozygous (from parent cell line).
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0038 (HaCaT)
Sex of cell Male
Age at sampling 62Y
Category Spontaneously immortalized cell line
Publications

PubMed=26989177; DOI=10.1242/dev.133728; PMCID=PMC4874484
Ahmed Elbediwy, Zoe I. Vincent-Mistiaen, Bradley Spencer-Dene, Richard K. Stone, Stefan Boeing, Stefanie Kristin Wculek, Julia Cordero, Ee H. Tan, Rachel Ridgway, Valerie G. Brunton, Erik Sahai ...Show all 16 authors... , Holger Gerhardt, Axel Behrens, Ilaria Malanchi, Owen James Sansom, Barry James Thompson; Show fewer authors
Integrin signalling regulates YAP and TAZ to control skin homeostasis.
Development 143:1674-1687(2016)

Cross-references
Encyclopedic resources Wikidata; Q54872315
Gene expression databases GEO; GSM2112564
GEO; GSM2112565
GEO; GSM2112566
Entry history
Entry creation15-Nov-2017
Last entry update10-Apr-2025
Version number14