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Cellosaurus HaCaT-TRS4 (CVCL_RL61)

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Cell line name HaCaT-TRS4
Accession CVCL_RL61
Resource Identification Initiative To cite this cell line use: HaCaT-TRS4 (RRID:CVCL_RL61)
Comments Population: Caucasian.
Characteristics: Expresses tetracyclin-inducible SMAD4 siRNA.
Knockout cell: Method=siRNA knockdown; HGNC; HGNC:6770; SMAD4.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P04483; Escherichia coli Tn10 tetR.
Derived from site: In situ; Back, skin, epidermis; UBERON=UBERON_0001068+UBERON_0001003.
Cell type: Keratinocyte; CL=CL_0000312.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.His179Tyr (c.535C>T); ClinVar=VCV000127815; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg282Trp (c.843_844CC>TT); Zygosity=Heterozygous (from parent cell line).
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0038 (HaCaT)
Sex of cell Male
Age at sampling 62Y
Category Spontaneously immortalized cell line
Publications

PubMed=16135802; DOI=10.1128/mcb.25.18.8108-8125.2005; PMCID=PMC1234333
Laurence Levy, Caroline Susan Hill;
Smad4 dependency defines two classes of transforming growth factor beta (TGF-beta) target genes and distinguishes TGF-beta-induced epithelial-mesenchymal transition from its antiproliferative and migratory responses.
Mol. Cell. Biol. 25:8108-8125(2005)

Cross-references
Encyclopedic resources Wikidata; Q54872316
Entry history
Entry creation05-Mar-2018
Last entry update19-Dec-2024
Version number12