Cellosaurus cell line NOK-SI (CVCL

Cellosaurus NOK-SI (CVCL_BW57)

[Text version]

Cell line name

NOK-SI

Synonyms

NOKSI; NOKsi; Normal Oral Keratinocytes-Spontaneously Immortalized

Accession

CVCL_BW57

Resource Identification Initiative

To cite this cell line use: NOK-SI (RRID:CVCL_BW57)

Comments

Problematic cell line: Contaminated. Shown to be a HaCaT derivative (ICLAC). Originally thought to originate from normal oral keratinocytes from a female donor.
Part of: OPC-22 oral and pharyngeal cancer cell line panel.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00589.
Population: Caucasian.
Omics: Genomics; Whole exome sequencing.
Derived from site: In situ; Back, skin, epidermis; UBERON=UBERON_0001068+UBERON_0001003.
Cell type: Keratinocyte; CL=CL_0000312.

Sequence variations

Mutation; HGNC; HGNC:11998; TP53; Simple; p.His179Tyr (c.535C>T); ClinVar=VCV000127815; Zygosity=Unspecified (PubMed=25275298).

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Parent: CVCL_0038 (HaCaT)

Sex of cell

Male

Age at sampling

62Y

Category

Spontaneously immortalized cell line

STR profile

Source(s): PubMed=25275298

Markers:

Amelogenin	X
CSF1PO	9,11
D3S1358	16
D5S818	12
D7S820	9,11
D8S1179	14
D13S317	10,12
D16S539	9,12
D18S51	12
D21S11	28,30.2
FGA	24
Penta D	11,13
Penta E	7,12
TH01	9.3
TPOX	11,12
vWA	16,17

Web pages

Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx

Publications

PubMed=20463891; DOI=10.1371/journal.pone.0010503; PMCID=PMC2865533
Rogerio Moraes Castilho, Cristiane H. Squarize, Kantima Leelahavanichkul, Yi Zheng, Thomas Bugge, J. Silvio Gutkind;
Rac1 is required for epithelial stem cell function during dermal and oral mucosal wound healing but not for tissue homeostasis in mice.
PLoS ONE 5:e10503.1-e10503.12(2010)

PubMed=25275298; DOI=10.18632/oncotarget.2417; PMCID=PMC4253406
Daniel Martin, Martin C. Abba, Alfredo Alberto Molinolo, Lynn Vitale-Cross, Zhi-Yong Wang, Moraima Zaida, Naomi C. Delic, Yardena Samuels, J. Guy Lyons, J. Silvio Gutkind;
The head and neck cancer cell oncogenome: a platform for the development of precision molecular therapies.
Oncotarget 5:8906-8923(2014)

Cross-references

Encyclopedic resources

Wikidata; Q54930891

Polymorphism and mutation databases

Cosmic; 2296312

Entry history

Entry creation

02-May-2016

Last entry update

10-Apr-2025

Version number