ID   NOK-SI
AC   CVCL_BW57
SY   NOKSI; NOKsi; Normal Oral Keratinocytes-Spontaneously Immortalized
DR   Cosmic; 2296312
DR   Wikidata; Q54930891
RX   PubMed=20463891;
RX   PubMed=25275298;
WW   Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
CC   Problematic cell line: Contaminated. Shown to be a HaCaT derivative (ICLAC). Originally thought to originate from normal oral keratinocytes from a female donor.
CC   Part of: OPC-22 oral and pharyngeal cancer cell line panel.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00589.
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.His179Tyr (c.535C>T); ClinVar=VCV000127815; Zygosity=Unspecified (PubMed=25275298).
CC   Omics: Genomics; Whole exome sequencing.
CC   Derived from site: In situ; Back, skin, epidermis; UBERON=UBERON_0001068+UBERON_0001003.
CC   Cell type: Keratinocyte; CL=CL_0000312.
ST   Source(s): PubMed=25275298
ST   Amelogenin: X
ST   CSF1PO: 9,11
ST   D13S317: 10,12
ST   D16S539: 9,12
ST   D18S51: 12
ST   D21S11: 28,30.2
ST   D3S1358: 16
ST   D5S818: 12
ST   D7S820: 9,11
ST   D8S1179: 14
ST   FGA: 24
ST   Penta D: 11,13
ST   Penta E: 7,12
ST   TH01: 9.3
ST   TPOX: 11,12
ST   vWA: 16,17
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0038 ! HaCaT
SX   Male
AG   62Y
CA   Spontaneously immortalized cell line
DT   Created: 02-05-16; Last updated: 10-04-25; Version: 13
//
RX   PubMed=20463891; DOI=10.1371/journal.pone.0010503; PMCID=PMC2865533;
RA   Castilho, Rogerio Moraes
RA   Squarize, Cristiane H.
RA   Leelahavanichkul, Kantima
RA   Zheng, Yi
RA   Bugge, Thomas
RA   Gutkind, Jorge Silvio
RT   "Rac1 is required for epithelial stem cell function during dermal and
RT   oral mucosal wound healing but not for tissue homeostasis in mice.";
RL   PLoS ONE 5:e10503.1-e10503.12(2010).
//
RX   PubMed=25275298; DOI=10.18632/oncotarget.2417; PMCID=PMC4253406;
RA   Martin, Daniel
RA   Abba, Martin Carlos
RA   Molinolo, Alfredo Alberto
RA   Vitale-Cross, Lynn
RA   Wang, Zhi-Yong
RA   Zaida, Moraima
RA   Delic, Naomi C.
RA   Samuels, Yardena
RA   Lyons, J. Guy
RA   Gutkind, Jorge Silvio
RT   "The head and neck cancer cell oncogenome: a platform for the
RT   development of precision molecular therapies.";
RL   Oncotarget 5:8906-8923(2014).
//