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Cellosaurus HaCaT BHLHE40 (-/-) (CVCL_HD65)

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Cell line name HaCaT BHLHE40 (-/-)
Synonyms BHLHE40 (-/-) HACAT; DEC1-/- HaCaT
Accession CVCL_HD65
Resource Identification Initiative To cite this cell line use: HaCaT BHLHE40 (-/-) (RRID:CVCL_HD65)
Comments Population: Caucasian.
Knockout cell: Method=Homologous recombination; HGNC; HGNC:1046; BHLHE40.
Derived from site: In situ; Back, skin, epidermis; UBERON=UBERON_0001068+UBERON_0001003.
Cell type: Keratinocyte; CL=CL_0000312.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.His179Tyr (c.535C>T); ClinVar=VCV000127815; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg282Trp (c.843_844CC>TT); Zygosity=Heterozygous (from parent cell line).
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0038 (HaCaT)
Sex of cell Male
Age at sampling 62Y
Category Spontaneously immortalized cell line
Publications

PubMed=11880636; DOI=10.1073/pnas.261714999; PMCID=PMC122436
Leigh Zawel, Jian Yu, Christopher J. Torrance, Sanford David Markowitz, Kenneth Wayne Kinzler, Bert Vogelstein, Shi-Bin Zhou;
DEC1 is a downstream target of TGF-beta with sequence-specific transcriptional repressor activities.
Proc. Natl. Acad. Sci. U.S.A. 99:2848-2853(2002)

Cross-references
Cell line collections (Providers) Horizon_Discovery; HD+R01-001
Encyclopedic resources Wikidata; Q54872309
Entry history
Entry creation01-Dec-2016
Last entry update19-Dec-2024
Version number11