ID   HaCaT BHLHE40 (-/-)
AC   CVCL_HD65
SY   BHLHE40 (-/-) HACAT; DEC1-/- HaCaT
DR   Horizon_Discovery; HD+R01-001
DR   Wikidata; Q54872309
RX   PubMed=11880636;
CC   Population: Caucasian.
CC   Knockout cell: Method=Homologous recombination; HGNC; HGNC:1046; BHLHE40.
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.His179Tyr (c.535C>T); ClinVar=VCV000127815; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg282Trp (c.843_844CC>TT); Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: In situ; Back, skin, epidermis; UBERON=UBERON_0001068+UBERON_0001003.
CC   Cell type: Keratinocyte; CL=CL_0000312.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0038 ! HaCaT
SX   Male
AG   62Y
CA   Spontaneously immortalized cell line
DT   Created: 01-12-16; Last updated: 19-12-24; Version: 11
//
RX   PubMed=11880636; DOI=10.1073/pnas.261714999; PMCID=PMC122436;
RA   Zawel, Leigh
RA   Yu, Jian
RA   Torrance, Christopher J.
RA   Markowitz, Sanford David
RA   Kinzler, Kenneth Wayne
RA   Vogelstein, Bert
RA   Zhou, Shi-Bin
RT   "DEC1 is a downstream target of TGF-beta with sequence-specific
RT   transcriptional repressor activities.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:2848-2853(2002).
//