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Cellosaurus HaCaT40degree (CVCL_XK18)

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Cell line name HaCaT40degree
Accession CVCL_XK18
Resource Identification Initiative To cite this cell line use: HaCaT40degree (RRID:CVCL_XK18)
Comments Population: Caucasian.
Characteristics: Adapted to grow at 40 Celsius.
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:5173; HRAS.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: In situ; Back, skin, epidermis; UBERON=UBERON_0001068+UBERON_0001003.
Cell type: Keratinocyte; CL=CL_0000312.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.His179Tyr (c.535C>T); ClinVar=VCV000127815; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg282Trp (c.843_844CC>TT); Zygosity=Heterozygous (from parent cell line).
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0038 (HaCaT)
Sex of cell Male
Age at sampling 62Y
Category Spontaneously immortalized cell line
Publications

PubMed=10523843; DOI=10.1038/sj.onc.1202934
Petra Boukamp, Susanne Popp, Kerstin Bleuel, E. Tomakidi, Alexander Burkle, Norbert E. Fusenig;
Tumorigenic conversion of immortal human skin keratinocytes (HaCaT) by elevated temperature.
Oncogene 18:5638-5645(1999)

PubMed=11583982; DOI=10.1016/S0002-9440(10)62541-2; PMCID=PMC1850484
Margareta M. Mueller, Wolfgang Peter, Marion Mappes, Andrea Huelsen, Heinrich Steinbauer, Petra Boukamp, Michael Anthony Vaccariello, Jonathan A. Garlick, Norbert E. Fusenig;
Tumor progression of skin carcinoma cells in vivo promoted by clonal selection, mutagenesis, and autocrine growth regulation by granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor.
Am. J. Pathol. 159:1567-1579(2001)

Cross-references
Encyclopedic resources Wikidata; Q93937740
Entry history
Entry creation19-Dec-2019
Last entry update27-Nov-2025
Version number11