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Cellosaurus Y-79 (CVCL_1893)

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Cell line name Y-79
Synonyms Y79; GM01232; GM01232E
Accession CVCL_1893
Resource Identification Initiative To cite this cell line use: Y-79 (RRID:CVCL_1893)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Caucasian.
Doubling time: 52 hours (PubMed=4135597); 47 hours (PubMed=25326674); 24-28 hours (DOI=10.5005/jp-journals-10082-02230); ~40 hours (DSMZ=ACC-246).
Omics: Array-based CGH.
Omics: Deep exome analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Anecdotal: Named Y-79 because it was the result of the 79th attempt of a group at Yale to establish a retinoblastoma cell line.
Derived from site: In situ; Eye, globe; UBERON=UBERON_0010230.
Sequence variations
  • Mutation; HGNC; 9884; RB1; Unexplicit; Ex2-6del; Zygosity=Heterozygous (PubMed=3413073; PubMed=25326674).
  • Mutation; HGNC; 9884; RB1; Unexplicit; IVS20+1G>A; Zygosity=Heterozygous (PubMed=3413073; PubMed=25326674).
HLA typing Source: CLS=300382
Class I
Class II
Disease Retinoblastoma (NCIt: C7541)
Retinoblastoma (ORDO: Orphanet_790)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_S611 (RB355)CVCL_S610 (WERI-Rb-27)CVCL_B7IF (Y-79 CDDP-R)
CVCL_B7IG (Y-79 Eto-R)CVCL_VA40 (Y79-6)CVCL_ZF06 (Y79-Luc)
Sex of cell Female
Age at sampling 2Y6M
Category Cancer cell line
STR profile Source(s): AddexBio=C0029001/4898; ATCC=HTB-18; CLS=300382; DepMap=ACH-001295; DSMZ=ACC-246; ECACC=86093003; ICLC=HTL99029; JCRB=JCRB3020; RCB=RCB1645

D5S81811 (ICLC=HTL99029)
11,12 (AddexBio=C0029001/4898; ATCC=HTB-18; CLS=300382; DepMap=ACH-001295; DSMZ=ACC-246; ECACC=86093003; JCRB=JCRB3020; RCB=RCB1645)
FGA20,22 (ATCC=HTB-18; DepMap=ACH-001295; DSMZ=ACC-246)
22 (CLS=300382)
Penta D12
Penta E13,18
TH016 (JCRB=JCRB3020)
6,9.3 (AddexBio=C0029001/4898; ATCC=HTB-18; CLS=300382; DepMap=ACH-001295; ECACC=86093003; ICLC=HTL99029; RCB=RCB1645)
6,10 (DSMZ=ACC-246)

Run an STR similarity search on this cell line

PubMed=4135597; DOI=10.1093/jnci/53.2.347
Reid T.W., Albert D.M., Rabson A.S., Russell P., Craft J.L., Chu E.W., Tralka T.S., Wilcox J.L.
Characteristics of an established cell line of retinoblastoma.
J. Natl. Cancer Inst. 53:347-360(1974)

McFall R.C., Nagy R.M., Nagle B.T., McGreevy L.M.
Scanning electron microscopic observation of two retinoblastoma cell lines.
Cancer Res. 38:2827-2835(1978)

PubMed=6167750; DOI=10.1093/jnci/67.2.301
Gilbert F., Balaban G.B., Breg W.R., Gallie B.L., Reid T.W., Nichols W.W.
Homogeneously staining region in a retinoblastoma cell line: relevance to tumor initiation and progression.
J. Natl. Cancer Inst. 67:301-306(1981)

PubMed=6351622; DOI=10.1016/S0002-9394(14)77822-5
Ohashi Y., Sasabe T., Nishida T., Nishi Y., Higashi H.
Hanganutziu-Deicher heterophile antigen in human retinoblastoma cells.
Am. J. Ophthalmol. 96:321-325(1983)

Tsumuraya M., Nakajima T., Terasaki T., Kodama T., Shimosato Y., Higuchi H., Uei Y.
Analysis of LDH isoenzyme patterns in cell lines of the small cell carcinoma (lung) and retinoblastoma.
Nihon Rinsho Saibo Gakkai Zasshi 24:451-456(1985)

PubMed=3518877; DOI=10.3109/07357908609038260
Fogh J.
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

PubMed=3413073; DOI=10.1073/pnas.85.16.6017
Lee E.Y.-H.P., Bookstein R., Young L.-J., Lin C.-J., Rosenfeld M.G., Lee W.-H.
Molecular mechanism of retinoblastoma gene inactivation in retinoblastoma cell line Y79.
Proc. Natl. Acad. Sci. U.S.A. 85:6017-6021(1988)

PubMed=2917337; DOI=10.1016/0165-4608(89)90079-4
Horsthemke B., Greger V., Becher R., Passarge E.
Mechanism of i(6p) formation in retinoblastoma tumor cells.
Cancer Genet. Cytogenet. 37:95-102(1989)

PubMed=1679230; DOI=10.3109/13816819109023085
Madreperla S.A., Bookstein R., Jones O.W., Lee W.-H.
Retinoblastoma cell lines Y79, RB355 and WERI-Rb27 are genetically related.
Ophthalmic Paediatr. Genet. 12:49-56(1991)

Mulivor R.A., Suchy S.F.
1992/1993 catalog of cell lines. NIGMS human genetic mutant cell repository. 16th edition. October 1992.
(In) Institute for Medical Research (Camden, N.J.) NIH 92-2011; pp.1-918; National Institutes of Health; Bethesda (1992)

PubMed=7689221; DOI=10.1073/pnas.90.16.7578
Godbout R., Squire J.A.
Amplification of a DEAD box protein gene in retinoblastoma cell lines.
Proc. Natl. Acad. Sci. U.S.A. 90:7578-7582(1993)

PubMed=7499444; DOI=10.1007/BF01213319
Inomata M., Saijo N., Kawashima K., Kaneko A., Fujiwara Y., Kunikane H., Tanaka Y.
Induction of apoptosis in cultured retinoblastoma cells by the protein phosphatase inhibitor, okadaic acid.
J. Cancer Res. Clin. Oncol. 121:729-738(1995)

PubMed=18036396; DOI=10.1016/j.cancergencyto.2007.08.014
Paderova J., Orlic-Milacic M., Yoshimoto M., da Cunha Santos G., Gallie B.L., Squire J.A.
Novel 6p rearrangements and recurrent translocation breakpoints in retinoblastoma cell lines identified by spectral karyotyping and mBAND analyses.
Cancer Genet. Cytogenet. 179:102-111(2007)

PubMed=18799932; DOI=10.1097/MPH.0b013e31816e232d
Kim J.H., Kim J.H., Yu Y.S., Kim D.H., Kim Y.K., Kim K.-W.
Comparative genomic hybridization analysis of newly established retinoblastoma cell lines of adherent growth compared with Y79 of nonadherent growth.
J. Pediatr. Hematol. Oncol. 30:571-574(2008)

PubMed=19686387; DOI=10.1111/j.1471-4159.2009.06322.x
Glubrecht D.D., Kim J.-H., Russell L., Bamforth J.S., Godbout R.
Differential CRX and OTX2 expression in human retina and retinoblastoma.
J. Neurochem. 111:250-263(2009)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=21697133; DOI=10.1167/iovs.11-7479
Oshikawa M., Tsutsui C., Ikegami T., Fuchida Y., Matsubara M., Toyama S., Usami R., Ohtoko K., Kato S.
Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method.
Invest. Ophthalmol. Vis. Sci. 52:6662-6670(2011)

PubMed=23498719; DOI=10.1016/S1470-2045(13)70045-7
Rushlow D.E., Mol B.M., Kennett J.Y., Yee S., Pajovic S., Theriault B.L., Prigoda-Lee N.L., Spencer C., Dimaras H., Corson T.W., Pang R., Massey C., Godbout R., Jiang Z., Zacksenhaus E., Paton K., Moll A.C., Houdayer C., Raizis A., Halliday W., Lam W.L., Boutros P.C., Lohmann D.R., Dorsman J.C., Gallie B.L.
Characterisation of retinoblastomas without RB1 mutations: genomic, gene expression, and clinical studies.
Lancet Oncol. 14:327-334(2013)

PubMed=25326674; DOI=10.1007/s00418-014-1285-z
Busch M.A., Philippeit C., Weise A., Dunker N.
Re-characterization of established human retinoblastoma cell lines.
Histochem. Cell Biol. 143:325-338(2015)

PubMed=27050416; DOI=10.1371/journal.pone.0153011
Ferrario A., Luna M., Rucker N., Wong S., Lederman A., Kim J., Gomer C.
Targeting survivin enhances chemosensitivity in retinoblastoma cells and orthotopic tumors.
PLoS ONE 11:E0153011-E0153011(2016)

PubMed=27115612; DOI=10.1371/journal.pone.0153323
Kooi I.E., Mol B.M., Massink M.P.G., de Jong M.C., de Graaf P., van der Valk P., Meijers-Heijboer H., Kaspers G.J.L., Moll A.C., te Riele H., Cloos J., Dorsman J.C.
A meta-analysis of retinoblastoma copy numbers refines the list of possible driver genes involved in tumor progression.
PLoS ONE 11:E0153323-E0153323(2016)

Song W.-P., Zhang C.-Y., Zhang Y., Li Y., Cao R., Ye C., Zhang L., Shao R.-G., Li L., Zhao J.-Y.
Generation of etoposide-resistant subline of human retinoblastoma Y79 cells and preliminary study of its resistance mechanism.
Zhongguo Yiyao Sheng Wu Jishu 12:297-302(2017)

PubMed=29162051; DOI=10.1186/s12885-017-3750-2
Nair R.M., Balla M.M.S., Khan I., Kalathur R.K.R., Kondaiah P., Vemuganti G.K.
In vitro characterization of CD133(lo) cancer stem cells in retinoblastoma Y79 cell line.
BMC Cancer 17:779.1-779.12(2017)

PubMed=29192327; DOI=10.3892/or.2017.6100
Busch M.A., Papior D., Stephan H., Dunker N.
Characterization of etoposide- and cisplatin-chemoresistant retinoblastoma cell lines.
Oncol. Rep. 39:160-172(2018)

Kuduvalli S.S., Ramalakshmi O., Precilla S.D., Anitha T.S.
Evaluation of cell doubling time in C6 and Y79 cell lines based on seeding density.
SBV J. Basic Clin. Appl. Heatlh Sci. 2:146-149(2019)

PubMed=30584916; DOI=10.1016/j.yexcr.2018.12.018
Schwermer M., Hiber M., Dreesmann S., Rieb A., Theissen J., Herold T., Schramm A., Temming P., Steenpass L.
Comprehensive characterization of RB1 mutant and MYCN amplified retinoblastoma cell lines.
Exp. Cell Res. 375:92-99(2019)

PubMed=32123578; DOI=10.1038/s41420-020-0237-8
Aubry A., Yu T., Bremner R.
Preclinical studies reveal MLN4924 is a promising new retinoblastoma therapy.
Cell Death Discov. 6:2.1-2.12(2020)

PubMed=32143590; DOI=10.1186/s12886-020-01348-6
Song W.-P., Zheng S., Yao H.-J., Zhou X.-F., Li R., Zhang C.-Y., Zhao J.-Y., Wang L.-W., Shao R.-G., Li L.
Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism.
BMC Ophthalmol. 20:92.1-92.11(2020)

Cell line collections (Providers) AddexBio; C0029001/4898
BCRC; 60422
BCRJ; 0380
CLS; 300382
Coriell; GM01232
ECACC; 86093003
IBRC; C11182
ICLC; HTL99029
JCRB; KURB2684 - Discontinued
NCBI_Iran; C201
RCB; RCB0427 - Discontinued
RCB; RCB1645
Cell line databases/resources CLO; CLO_0009709
CLO; CLO_0030277
CLO; CLO_0051564
CLDB; cl4796
CLDB; cl4798
CLDB; cl4797
CLDB; cl4984
cancercelllines; CVCL_1893
Cell_Model_Passport; SIDM01395
DepMap; ACH-001295
DSMZCellDive; ACC-246
IGRhCellID; Y79
Anatomy/cell type resources BTO; BTO:0002920
Biological sample resources BioSample; SAMN00803744
BioSample; SAMN01821607
BioSample; SAMN03472733
BioSample; SAMN03473388
Chemistry resources ChEMBL-Cells; CHEMBL3308054
ChEMBL-Targets; CHEMBL613820
PubChem_Cell_line; CVCL_1893
Encyclopedic resources Wikidata; Q54995129
Experimental variables resources EFO; EFO_0002392
Gene expression databases ArrayExpress; E-MTAB-38
GEO; GSM1250686
GEO; GSM1250688
GEO; GSM1486288
GEO; GSM2043882
Polymorphism and mutation databases Cosmic; 688120
Cosmic; 808507
Cosmic; 1071899
Cosmic; 1176623
Progenetix; CVCL_1893
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number39