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Cellosaurus Y-79 (CVCL_1893)

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Cell line name Y-79
Synonyms Y79; GM01232; GM01232E
Accession CVCL_1893
Resource Identification Initiative To cite this cell line use: Y-79 (RRID:CVCL_1893)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Population: Caucasian.
Doubling time: 52 hours (PubMed=4135597); 47 hours (PubMed=25326674); 24-28 hours (DOI=10.5005/jp-journals-10082-02230); ~40 hours (DSMZ=ACC-246).
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Omics: Variations; SNP array analysis.
Anecdotal: Named Y-79 because it was the result of the 79th attempt of a group at Yale to establish a retinoblastoma cell line.
Derived from site: In situ; Eye, globe; UBERON=UBERON_0010230.
Sequence variations
HLA typing Source: CLS=300382
Class I
HLA-AA*02:01:01
HLA-BB*40:01:02,51:01:01
HLA-CC*03:04:01,12:03:01
Class II
HLA-DPDPB1*03:01,04:01
HLA-DQDQA1*01:01:01,01:02:01
DQB1*05:01:01,06:04:01
HLA-DRDRB1*01:01:01,13:02:01
Disease Retinoblastoma (NCIt: C7541)
Retinoblastoma (ORDO: Orphanet_790)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_S611 (RB355)CVCL_E1F7 (Ubigene Y-79 SFXN5 KO)CVCL_S610 (WERI-Rb-27)
CVCL_B7IF (Y-79 CDDP-R)CVCL_B7IG (Y-79 Eto-R)CVCL_VA40 (Y79-6)
CVCL_ZF06 (Y79-Luc)CVCL_A5SR (Y79/EDR)
Sex of cell Female
Age at sampling 2Y6M
Category Cancer cell line
STR profile Source(s): AddexBio=C0029001/4898; ATCC=HTB-18; CLS=300382; DepMap=ACH-001295; DSMZ=ACC-246; ECACC=86093003; ICLC=HTL99029; JCRB=JCRB3020; RCB=RCB1645

Markers:
AmelogeninX
CSF1PO11,12
D2S133820
D3S135815,16
D5S81811 (ICLC=HTL99029)
11,12 (AddexBio=C0029001/4898; ATCC=HTB-18; CLS=300382; DepMap=ACH-001295; DSMZ=ACC-246; ECACC=86093003; JCRB=JCRB3020; RCB=RCB1645)
D7S8208,9
D8S117913,16
D13S31711,12
D16S53913,14
D18S5113,16
D19S43313
D21S1130,32
FGA20,22 (ATCC=HTB-18; DepMap=ACH-001295; DSMZ=ACC-246)
22 (CLS=300382)
Penta D12
Penta E13,18
TH016 (JCRB=JCRB3020)
6,9.3 (AddexBio=C0029001/4898; ATCC=HTB-18; CLS=300382; DepMap=ACH-001295; ECACC=86093003; ICLC=HTL99029; RCB=RCB1645)
6,10 (DSMZ=ACC-246)
TPOX8
vWA15,18

Run an STR similarity search on this cell line
Publications

PubMed=4135597; DOI=10.1093/jnci/53.2.347
Ted W. Reid, Daniel M. Albert, Alan Saul Rabson, Paul Russell, Joseph L. Craft, Elizabeth W. Chu, Tommie Sue Tralka, Janice L. Wilcox;
Characteristics of an established cell line of retinoblastoma.
J. Natl. Cancer Inst. 53:347-360(1974)

PubMed=679190
Rosemary C. McFall, Rose Marie Nagy, Barbara T. Nagle, Loily M. McGreevy;
Scanning electron microscopic observation of two retinoblastoma cell lines.
Cancer Res. 38:2827-2835(1978)

PubMed=6167750; DOI=10.1093/jnci/67.2.301
Fred Gilbert, Gloria Brady Balaban-Malenbaum, William Roy Breg, Brenda Louise Gallie, Ted W. Reid, Warren W. Nichols;
Homogeneously staining region in a retinoblastoma cell line: relevance to tumor initiation and progression.
J. Natl. Cancer Inst. 67:301-306(1981)

PubMed=6351622; DOI=10.1016/S0002-9394(14)77822-5
Yuichi Ohashi, Tetsuo Sasabe, Teruo Nishida, Yasuaki Nishi, Hideyoshi Higashi;
Hanganutziu-Deicher heterophile antigen in human retinoblastoma cells.
Am. J. Ophthalmol. 96:321-325(1983)

DOI=10.5795/jjscc.24.451
Masaru Tsumuraya, Takashi Nakajima, Takeo Terasaki, Tetsuro Kodama, Yukio Shimosato, Hisaaki Higuchi, Yoshio Uei;
Analysis of LDH isoenzyme patterns in cell lines of the small cell carcinoma (lung) and retinoblastoma.
Nihon Rinsho Saibo Gakkai Zasshi 24:451-456(1985)

PubMed=3518877; DOI=10.3109/07357908609038260
Jorgen Fogh;
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

PubMed=3413073; DOI=10.1073/pnas.85.16.6017; PMCID=PMC281896
Eva Y.-H.P. Lee, Robert Bookstein, Lih-Jiuan Young, Chi-Jen Lin, Michael Geoffrey Rosenfeld, Wen-Hwa Lee;
Molecular mechanism of retinoblastoma gene inactivation in retinoblastoma cell line Y79.
Proc. Natl. Acad. Sci. U.S.A. 85:6017-6021(1988)

PubMed=2917337; DOI=10.1016/0165-4608(89)90079-4
Bernhard Horsthemke, Valerie Greger, Reinhard Becher, Eberhard Passarge;
Mechanism of i(6p) formation in retinoblastoma tumor cells.
Cancer Genet. Cytogenet. 37:95-102(1989)

PubMed=1679230; DOI=10.3109/13816819109023085
Steven A. Madreperla, Robert Bookstein, Oliver W. Jones, Wen-Hwa Lee;
Retinoblastoma cell lines Y79, RB355 and WERI-Rb27 are genetically related.
Ophthalmic Paediatr. Genet. 12:49-56(1991)

CLPUB00447
Richard A. Mulivor, Sharon F. Suchy;
1992/1993 catalog of cell lines. NIGMS human genetic mutant cell repository. 16th edition. October 1992.
(In misc. document) Institute for Medical Research (Camden, N.J.) NIH 92-2011; pp.1-918; National Institutes of Health; Bethesda; USA (1992)

PubMed=7689221; DOI=10.1073/pnas.90.16.7578; PMCID=PMC47185
Roseline Godbout, Jeremy Andrew Squire;
Amplification of a DEAD box protein gene in retinoblastoma cell lines.
Proc. Natl. Acad. Sci. U.S.A. 90:7578-7582(1993)

PubMed=7499444; DOI=10.1007/BF01213319
Motoko Inomata, Nagahiro Saijo, Kazuko Kawashima, Akihiro Kaneko, Yasuhiro Fujiwara, Hiroshi Kunikane, Yasuhiko Tanaka;
Induction of apoptosis in cultured retinoblastoma cells by the protein phosphatase inhibitor, okadaic acid.
J. Cancer Res. Clin. Oncol. 121:729-738(1995)

PubMed=18036396; DOI=10.1016/j.cancergencyto.2007.08.014
Jana Paderova, Marija Orlic-Milacic, Maisa Yoshimoto, Gilda da Cunha Santos, Brenda Louise Gallie, Jeremy Andrew Squire;
Novel 6p rearrangements and recurrent translocation breakpoints in retinoblastoma cell lines identified by spectral karyotyping and mBAND analyses.
Cancer Genet. Cytogenet. 179:102-111(2007)

PubMed=18799932; DOI=10.1097/MPH.0b013e31816e232d
Jeong Hun Kim, Jin Hyoung Kim, Young Suk Yu, Dong Hun Kim, Yong Kyu Kim, Kyu-Won Kim;
Comparative genomic hybridization analysis of newly established retinoblastoma cell lines of adherent growth compared with Y79 of nonadherent growth.
J. Pediatr. Hematol. Oncol. 30:571-574(2008)

PubMed=19686387; DOI=10.1111/j.1471-4159.2009.06322.x; PMCID=PMC3726384
Darryl D. Glubrecht, Ji-Hyeon Kim, Laurie Russell, John Stephen Bamforth, Roseline Godbout;
Differential CRX and OTX2 expression in human retina and retinoblastoma.
J. Neurochem. 111:250-263(2009)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=21697133; DOI=10.1167/iovs.11-7479
Mio Oshikawa, Chihiro Tsutsui, Tomoko Ikegami, Yuki Fuchida, Maki Matsubara, Shigeru Toyama, Ron Usami, Kuniyo Ohtoko, Seishi Kato;
Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method.
Invest. Ophthalmol. Vis. Sci. 52:6662-6670(2011)

PubMed=23498719; DOI=10.1016/S1470-2045(13)70045-7
Diane E. Rushlow, Berber M. Mol, Jennifer Y. Kennett, Stephanie Yee, Sanja Pajovic, Brigitte L. Theriault, Nadia L. Prigoda-Lee, Clarellen Spencer, Helen Dimaras, Timothy W. Corson, Renee Pang ...Show all 25 authors... , Christine Massey, Roseline Godbout, Zhe Jiang, Eldad Zacksenhaus, Katherine Paton, Annette C. Moll, Claude Houdayer, Anthony Raizis, William Halliday, Wan L. Lam, Paul Christopher Boutros, Dietmar R. Lohmann, Josephine C. Dorsman, Brenda Louise Gallie; Show fewer authors
Characterisation of retinoblastomas without RB1 mutations: genomic, gene expression, and clinical studies.
Lancet Oncol. 14:327-334(2013)

PubMed=25326674; DOI=10.1007/s00418-014-1285-z
Maike Anna Busch, Claudia Philippeit, Andreas Weise, Nicole Dunker;
Re-characterization of established human retinoblastoma cell lines.
Histochem. Cell Biol. 143:325-338(2015)

PubMed=27050416; DOI=10.1371/journal.pone.0153011; PMCID=PMC4822873
Angela Ferrario, Marian C. Luna, Natalie Rucker, Sam Wong, Ariel Lederman, Jonathan Kim, Charles Joseph Gomer;
Targeting survivin enhances chemosensitivity in retinoblastoma cells and orthotopic tumors.
PLoS ONE 11:e0153011.1-e0153011.16(2016)

PubMed=27115612; DOI=10.1371/journal.pone.0153323; PMCID=PMC4846005
Irsan E. Kooi, Berber M. Mol, Maarten P.G. Massink, Marcus C. de Jong, Pim de Graaf, Paul van der Valk, Hanne Meijers-Heijboer, Gertjan J.L. Kaspers, Annette C. Moll, Hein te Riele, Jacqueline Cloos, Josephine C. Dorsman;
A meta-analysis of retinoblastoma copy numbers refines the list of possible driver genes involved in tumor progression.
PLoS ONE 11:e0153323.1-e0153323.20(2016)

DOI=10.3969/j.issn.1673-713X.2017.04.002
Wen-Ping Song, Cheng-Yue Zhang, Yan Zhang, Yi Li, Rui Cao, Cheng Ye, Lin Zhang, Rong-Guang Shao, Liang Li, Jun-Yang Zhao;
Generation of etoposide-resistant subline of human retinoblastoma Y79 cells and preliminary study of its resistance mechanism.
Zhongguo Yiyao Sheng Wu Jishu 12:297-302(2017)

PubMed=29162051; DOI=10.1186/s12885-017-3750-2; PMCID=PMC5698942
Rohini M. Nair, Murali M.S. Balla, Imran Khan, Ravi Kiran Reddy Kalathur, Paturu Kondaiah, Geeta K. Vemuganti;
In vitro characterization of CD133(lo) cancer stem cells in retinoblastoma Y79 cell line.
BMC Cancer 17:779.1-779.12(2017)

PubMed=29192327; DOI=10.3892/or.2017.6100; PMCID=PMC5783599
Maike Anna Busch, David Papior, Harald Stephan, Nicole Dunker;
Characterization of etoposide- and cisplatin-chemoresistant retinoblastoma cell lines.
Oncol. Rep. 39:160-172(2018)

DOI=10.5005/jp-journals-10082-02230
Shreyas S. Kuduvalli, O. Ramalakshmi, S. Daisy Precilla, Thirugnanasambandhar Sivasubramanian Anitha;
Evaluation of cell doubling time in C6 and Y79 cell lines based on seeding density.
SBV J. Basic Clin. Appl. Heatlh Sci. 2:146-149(2019)

PubMed=30584916; DOI=10.1016/j.yexcr.2018.12.018
Melanie Schwermer, Michaela Hiber, Sabine Dreesmann, Anja Rieb, Jessica Theissen, Thomas Herold, Alexander Schramm, Petra Temming, Laura Steenpass;
Comprehensive characterization of RB1 mutant and MYCN amplified retinoblastoma cell lines.
Exp. Cell Res. 375:92-99(2019)

PubMed=32123578; DOI=10.1038/s41420-020-0237-8; PMCID=PMC7026052
Arthur Aubry, Tao Yu, Rod Bremner;
Preclinical studies reveal MLN4924 is a promising new retinoblastoma therapy.
Cell Death Discov. 6:2.1-2.12(2020)

PubMed=32143590; DOI=10.1186/s12886-020-01348-6; PMCID=PMC7060629
Wen-Ping Song, Si Zheng, Hong-Juan Yao, Xiao-Fei Zhou, Rui Li, Cheng-Yue Zhang, Jun-Yang Zhao, Lie-Wei Wang, Rong-Guang Shao, Liang Li;
Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism.
BMC Ophthalmol. 20:92.1-92.11(2020)

Cross-references
Cell line collections (Providers) AddexBio; C0029001/4898
ATCC; HTB-18
BCRC; 60422
BCRJ; 0380
CLS; 300382
Coriell; GM01232
DSMZ; ACC-246
ECACC; 86093003
IBRC; C11182
ICLC; HTL99029
JCRB; JCRB3020
JCRB; KURB2684 - Discontinued
NCBI_Iran; C201
RCB; RCB0427 - Discontinued
RCB; RCB1645
Ubigene; YC-B015
Cell line databases/resources CLO; CLO_0009709
CLO; CLO_0030277
CLO; CLO_0051564
CLDB; cl4796
CLDB; cl4797
CLDB; cl4798
CLDB; cl4984
cancercelllines; CVCL_1893
Cell_Model_Passport; SIDM01395
DepMap; ACH-001295
DSMZCellDive; ACC-246
IGRhCellID; Y79
Anatomy/cell type resources BTO; BTO_0002920
Biological sample resources BioSample; SAMN00803744
BioSample; SAMN01821607
BioSample; SAMN03472733
BioSample; SAMN03473388
Chemistry resources ChEMBL-Cells; CHEMBL3308054
ChEMBL-Targets; CHEMBL613820
PubChem_Cell_line; CVCL_1893
Encyclopedic resources Wikidata; Q54995129
Experimental variables resources EFO; EFO_0002392
Gene expression databases ArrayExpress; E-MTAB-38
FANTOM5_SSTAR; 10475-106I7
GEO; GSM1250686
GEO; GSM1250688
GEO; GSM1486288
GEO; GSM2043882
Polymorphism and mutation databases Cosmic; 688120
Cosmic; 808507
Cosmic; 1071899
Cosmic; 1176623
Progenetix; CVCL_1893
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number42