Cellosaurus logo
expasy logo

Cellosaurus Y79/EDR (CVCL_A5SR)

[Text version]
Cell line name Y79/EDR
Accession CVCL_A5SR
Resource Identification Initiative To cite this cell line use: Y79/EDR (RRID:CVCL_A5SR)
Comments Population: Caucasian.
Doubling time: 14.5 hours (DOI=10.3969/j.issn.1673-713X.2017.04.002).
Selected for resistance to: ChEBI; CHEBI:4911; Etoposide (VP-16).
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Eye, globe; UBERON=UBERON_0010230.
Sequence variations
  • Mutation; HGNC; 9884; RB1; Unexplicit; Ex2-6del; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 9884; RB1; Unexplicit; IVS20+1G>A; Zygosity=Heterozygous (from parent cell line).
Disease Retinoblastoma (NCIt: C7541)
Retinoblastoma (ORDO: Orphanet_790)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1893 (Y-79)
Sex of cell Female
Age at sampling 2Y6M
Category Cancer cell line

Song W.-P., Zhang C.-Y., Zhang Y., Li Y., Cao R., Ye C., Zhang L., Shao R.-G., Li L., Zhao J.-Y.
Generation of etoposide-resistant subline of human retinoblastoma Y79 cells and preliminary study of its resistance mechanism.
Zhongguo Yiyao Sheng Wu Jishu 12:297-302(2017)

PubMed=32143590; DOI=10.1186/s12886-020-01348-6
Song W.-P., Zheng S., Yao H.-J., Zhou X.-F., Li R., Zhang C.-Y., Zhao J.-Y., Wang L.-W., Shao R.-G., Li L.
Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism.
BMC Ophthalmol. 20:92.1-92.11(2020)

Encyclopedic resources Wikidata; Q107117559
Entry history
Entry creation20-May-2021
Last entry update29-Jun-2023
Version number5