Cellosaurus cell line WERI-Rb-27 (CVCL

Cellosaurus WERI-Rb-27 (CVCL_S610)

Cross-references
Cell line name	WERI-Rb-27
Synonyms	WERI-Rb27; WERI-RB27; W-27; Wills Eye Research Institute-Retinoblastoma-27
Accession	CVCL_S610
Resource Identification Initiative	To cite this cell line use: WERI-Rb-27 (RRID:CVCL_S610)
Comments	Problematic cell line: Contaminated. Shown to be a Y-79 derivative (PubMed=1679230). Originally thought to originate from a 2 year old boy with a bilateral retinoblastoma. Population: Caucasian. Doubling time: 1.9 days (PubMed=2391623). Derived from site: In situ; Eye, globe; UBERON=UBERON_0010230.
Sequence variations	Mutation; HGNC; HGNC:9884; RB1; Unexplicit; Ex2-6del; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:9884; RB1; Unexplicit; IVS20+1G>A; Zygosity=Heterozygous (from parent cell line).
Disease	Retinoblastoma (NCIt: C7541) Retinoblastoma (ORDO: Orphanet_790)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_1893 (Y-79)
Sex of cell	Female
Age at sampling	2Y6M
Category	Cancer cell line
Publications	PubMed=2391623; DOI=10.3928/0191-3913-19900701-11 Theodore W. Sery, Eva Y.-H.P. Lee, Wen-Hwa Lee, Robert Bookstein, Vernon Wong, Jerry Allen Shields, James Jay Augsburger, Lawrence Albert Donoso; Characteristics of two new retinoblastoma cell lines: WERI-Rb24 and WERI-Rb27. J. Pediatr. Ophthalmol. Strabismus 27:212-217(1990) PubMed=1679230; DOI=10.3109/13816819109023085 Steven A. Madreperla, Robert Bookstein, Oliver W. Jones, Wen-Hwa Lee; Retinoblastoma cell lines Y79, RB355 and WERI-Rb27 are genetically related. Ophthalmic Paediatr. Genet. 12:49-56(1991)
Encyclopedic resources	Wikidata; Q54993784
Entry history
Entry creation	03-Feb-2014
Last entry update	19-Dec-2024
Version number	16