ID   Y-79
AC   CVCL_1893
SY   Y79; GM01232; GM01232E
DR   BTO; BTO_0002920
DR   CLO; CLO_0009709
DR   CLO; CLO_0030277
DR   CLO; CLO_0051564
DR   EFO; EFO_0002392
DR   CLDB; cl4796
DR   CLDB; cl4797
DR   CLDB; cl4798
DR   CLDB; cl4984
DR   AddexBio; C0029001/4898
DR   ArrayExpress; E-MTAB-38
DR   ATCC; HTB-18
DR   BCRC; 60422
DR   BCRJ; 0380
DR   BioSample; SAMN00803744
DR   BioSample; SAMN01821607
DR   BioSample; SAMN03472733
DR   BioSample; SAMN03473388
DR   cancercelllines; CVCL_1893
DR   Cell_Model_Passport; SIDM01395
DR   ChEMBL-Cells; CHEMBL3308054
DR   ChEMBL-Targets; CHEMBL613820
DR   CLS; 300382
DR   Coriell; GM01232
DR   Cosmic; 688120
DR   Cosmic; 808507
DR   Cosmic; 1071899
DR   Cosmic; 1176623
DR   DepMap; ACH-001295
DR   DSMZ; ACC-246
DR   DSMZCellDive; ACC-246
DR   ECACC; 86093003
DR   FANTOM5_SSTAR; 10475-106I7
DR   GEO; GSM1250686
DR   GEO; GSM1250688
DR   GEO; GSM1486288
DR   GEO; GSM2043882
DR   IBRC; C11182
DR   ICLC; HTL99029
DR   IGRhCellID; Y79
DR   JCRB; JCRB3020
DR   JCRB; KURB2684
DR   NCBI_Iran; C201
DR   Progenetix; CVCL_1893
DR   PubChem_Cell_line; CVCL_1893
DR   RCB; RCB0427
DR   RCB; RCB1645
DR   Ubigene; YC-B015
DR   Wikidata; Q54995129
RX   CelloPub=CLPUB00447;
RX   DOI=10.3969/j.issn.1673-713X.2017.04.002;
RX   DOI=10.5005/jp-journals-10082-02230;
RX   DOI=10.5795/jjscc.24.451;
RX   PubMed=679190;
RX   PubMed=1679230;
RX   PubMed=2917337;
RX   PubMed=3413073;
RX   PubMed=3518877;
RX   PubMed=4135597;
RX   PubMed=6167750;
RX   PubMed=6351622;
RX   PubMed=7499444;
RX   PubMed=7689221;
RX   PubMed=18036396;
RX   PubMed=18799932;
RX   PubMed=19686387;
RX   PubMed=20215515;
RX   PubMed=21697133;
RX   PubMed=23498719;
RX   PubMed=25326674;
RX   PubMed=27050416;
RX   PubMed=27115612;
RX   PubMed=29162051;
RX   PubMed=29192327;
RX   PubMed=30584916;
RX   PubMed=32123578;
RX   PubMed=32143590;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Population: Caucasian.
CC   Doubling time: 52 hours (PubMed=4135597); 47 hours (PubMed=25326674); 24-28 hours (DOI=10.5005/jp-journals-10082-02230); ~40 hours (DSMZ=ACC-246).
CC   HLA typing: A*02:01:01; B*40:01:02,51:01:01; C*03:04:01,12:03:01; DPB1*03:01,04:01; DQA1*01:01:01,01:02:01; DQB1*05:01:01,06:04:01; DRB1*01:01:01,13:02:01 (CLS=300382).
CC   Sequence variation: Mutation; HGNC; HGNC:9884; RB1; Unexplicit; Ex2-6del; Zygosity=Heterozygous (PubMed=3413073; PubMed=25326674).
CC   Sequence variation: Mutation; HGNC; HGNC:9884; RB1; Unexplicit; IVS20+1G>A; Zygosity=Heterozygous (PubMed=3413073; PubMed=25326674).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; Array-based CGH.
CC   Omics: Variations; SNP array analysis.
CC   Anecdotal: Named Y-79 because it was the result of the 79th attempt of a group at Yale to establish a retinoblastoma cell line.
CC   Discontinued: JCRB; KURB2684; probable.
CC   Discontinued: RCB; RCB0427; true.
CC   Derived from site: In situ; Eye, globe; UBERON=UBERON_0010230.
ST   Source(s): AddexBio=C0029001/4898; ATCC=HTB-18; CLS=300382; DepMap=ACH-001295; DSMZ=ACC-246; ECACC=86093003; ICLC=HTL99029; JCRB=JCRB3020; RCB=RCB1645
ST   Amelogenin: X
ST   CSF1PO: 11,12
ST   D13S317: 11,12
ST   D16S539: 13,14
ST   D18S51: 13,16
ST   D19S433: 13
ST   D21S11: 30,32
ST   D2S1338: 20
ST   D3S1358: 15,16
ST   D5S818: 11 (ICLC=HTL99029)
ST   D5S818: 11,12 (AddexBio=C0029001/4898; ATCC=HTB-18; CLS=300382; DepMap=ACH-001295; DSMZ=ACC-246; ECACC=86093003; JCRB=JCRB3020; RCB=RCB1645)
ST   D7S820: 8,9
ST   D8S1179: 13,16
ST   FGA: 20,22 (ATCC=HTB-18; DepMap=ACH-001295; DSMZ=ACC-246)
ST   FGA: 22 (CLS=300382)
ST   Penta D: 12
ST   Penta E: 13,18
ST   TH01: 6 (JCRB=JCRB3020)
ST   TH01: 6,9.3 (AddexBio=C0029001/4898; ATCC=HTB-18; CLS=300382; DepMap=ACH-001295; ECACC=86093003; ICLC=HTL99029; RCB=RCB1645)
ST   TH01: 6,10 (DSMZ=ACC-246)
ST   TPOX: 8
ST   vWA: 15,18
DI   NCIt; C7541; Retinoblastoma
DI   ORDO; Orphanet_790; Retinoblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   2Y6M
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 42
CH   CVCL_S611 ! RB355
CH   CVCL_E1F7 ! Ubigene Y-79 SFXN5 KO
CH   CVCL_S610 ! WERI-Rb-27
CH   CVCL_B7IF ! Y-79 CDDP-R
CH   CVCL_B7IG ! Y-79 Eto-R
CH   CVCL_VA40 ! Y79-6
CH   CVCL_ZF06 ! Y79-Luc
CH   CVCL_A5SR ! Y79/EDR
//
RX   PubMed=19686387; DOI=10.1111/j.1471-4159.2009.06322.x; PMCID=PMC3726384;
RA   Glubrecht, Darryl D.
RA   Kim, Ji-Hyeon
RA   Russell, Laurie
RA   Bamforth, John Stephen
RA   Godbout, Roseline
RT   "Differential CRX and OTX2 expression in human retina and
RT   retinoblastoma.";
RL   J. Neurochem. 111:250-263(2009).
//
RX   PubMed=29162051; DOI=10.1186/s12885-017-3750-2; PMCID=PMC5698942;
RA   Nair, Rohini M.
RA   Balla, Murali M.S.
RA   Khan, Imran
RA   Kalathur, Ravi Kiran Reddy
RA   Kondaiah, Paturu
RA   Vemuganti, Geeta K.
RT   "In vitro characterization of CD133(lo) cancer stem cells in
RT   retinoblastoma Y79 cell line.";
RL   BMC Cancer 17:779.1-779.12(2017).
//
RX   PubMed=7499444; DOI=10.1007/BF01213319;
RA   Inomata, Motoko
RA   Saijo, Nagahiro
RA   Kawashima, Kazuko
RA   Kaneko, Akihiro
RA   Fujiwara, Yasuhiro
RA   Kunikane, Hiroshi
RA   Tanaka, Yasuhiko
RT   "Induction of apoptosis in cultured retinoblastoma cells by the
RT   protein phosphatase inhibitor, okadaic acid.";
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//
RX   DOI=10.5005/jp-journals-10082-02230;
RA   Kuduvalli, Shreyas S.
RA   Ramalakshmi, O.
RA   Precilla, S. Daisy
RA   Anitha, Thirugnanasambandhar Sivasubramanian
RT   "Evaluation of cell doubling time in C6 and Y79 cell lines based on
RT   seeding density.";
RL   SBV J. Basic Clin. Appl. Heatlh Sci. 2:146-149(2019).
//
RX   PubMed=25326674; DOI=10.1007/s00418-014-1285-z;
RA   Busch, Maike Anna
RA   Philippeit, Claudia
RA   Weise, Andreas
RA   Dunker, Nicole
RT   "Re-characterization of established human retinoblastoma cell lines.";
RL   Histochem. Cell Biol. 143:325-338(2015).
//
RX   PubMed=32143590; DOI=10.1186/s12886-020-01348-6; PMCID=PMC7060629;
RA   Song, Wen-Ping
RA   Zheng, Si
RA   Yao, Hong-Juan
RA   Zhou, Xiao-Fei
RA   Li, Rui
RA   Zhang, Cheng-Yue
RA   Zhao, Jun-Yang
RA   Wang, Lie-Wei
RA   Shao, Rong-Guang
RA   Li, Liang
RT   "Different transcriptome profiles between human retinoblastoma Y79
RT   cells and an etoposide-resistant subline reveal a chemoresistance
RT   mechanism.";
RL   BMC Ophthalmol. 20:92.1-92.11(2020).
//
RX   DOI=10.5795/jjscc.24.451;
RA   Tsumuraya, Masaru
RA   Nakajima, Takashi
RA   Terasaki, Takeo
RA   Kodama, Tetsuro
RA   Shimosato, Yukio
RA   Higuchi, Hisaaki
RA   Uei, Yoshio
RT   "Analysis of LDH isoenzyme patterns in cell lines of the small cell
RT   carcinoma (lung) and retinoblastoma.";
RL   Nihon Rinsho Saibo Gakkai Zasshi 24:451-456(1985).
//
RX   PubMed=27115612; DOI=10.1371/journal.pone.0153323; PMCID=PMC4846005;
RA   Kooi, Irsan E.
RA   Mol, Berber M.
RA   Massink, Maarten P.G.
RA   de Jong, Marcus C.
RA   de Graaf, Pim
RA   van der Valk, Paul
RA   Meijers-Heijboer, Hanne
RA   Kaspers, Gertjan J.L.
RA   Moll, Annette C.
RA   te Riele, Hein
RA   Cloos, Jacqueline
RA   Dorsman, Josephine Christine
RT   "A meta-analysis of retinoblastoma copy numbers refines the list of
RT   possible driver genes involved in tumor progression.";
RL   PLoS ONE 11:e0153323.1-e0153323.20(2016).
//
RX   PubMed=2917337; DOI=10.1016/0165-4608(89)90079-4;
RA   Horsthemke, Bernhard
RA   Greger, Valerie
RA   Becher, Reinhard
RA   Passarge, Eberhard
RT   "Mechanism of i(6p) formation in retinoblastoma tumor cells.";
RL   Cancer Genet. Cytogenet. 37:95-102(1989).
//
RX   PubMed=6351622; DOI=10.1016/S0002-9394(14)77822-5;
RA   Ohashi, Yuichi
RA   Sasabe, Tetsuo
RA   Nishida, Teruo
RA   Nishi, Yasuaki
RA   Higashi, Hideyoshi
RT   "Hanganutziu-Deicher heterophile antigen in human retinoblastoma
RT   cells.";
RL   Am. J. Ophthalmol. 96:321-325(1983).
//
RX   PubMed=679190;
RA   McFall, Rosemary C.
RA   Nagy, Rose Marie
RA   Nagle, Barbara T.
RA   McGreevy, Loily M.
RT   "Scanning electron microscopic observation of two retinoblastoma cell
RT   lines.";
RL   Cancer Res. 38:2827-2835(1978).
//
RX   PubMed=1679230; DOI=10.3109/13816819109023085;
RA   Madreperla, Steven A.
RA   Bookstein, Robert
RA   Jones, Oliver W.
RA   Lee, Wen-Hwa
RT   "Retinoblastoma cell lines Y79, RB355 and WERI-Rb27 are genetically
RT   related.";
RL   Ophthalmic Paediatr. Genet. 12:49-56(1991).
//
RX   DOI=10.3969/j.issn.1673-713X.2017.04.002;
RA   Song, Wen-Ping
RA   Zhang, Cheng-Yue
RA   Zhang, Yan
RA   Li, Yi
RA   Cao, Rui
RA   Ye, Cheng
RA   Zhang, Lin
RA   Shao, Rong-Guang
RA   Li, Liang
RA   Zhao, Jun-Yang
RT   "Generation of etoposide-resistant subline of human retinoblastoma Y79
RT   cells and preliminary study of its resistance mechanism.";
RL   Zhongguo Yiyao Sheng Wu Jishu 12:297-302(2017).
//
RX   PubMed=18799932; DOI=10.1097/MPH.0b013e31816e232d;
RA   Kim, Jeong Hun
RA   Kim, Jin Hyoung
RA   Yu, Young Suk
RA   Kim, Dong Hun
RA   Kim, Yong Kyu
RA   Kim, Kyu-Won
RT   "Comparative genomic hybridization analysis of newly established
RT   retinoblastoma cell lines of adherent growth compared with Y79 of
RT   nonadherent growth.";
RL   J. Pediatr. Hematol. Oncol. 30:571-574(2008).
//
RX   PubMed=18036396; DOI=10.1016/j.cancergencyto.2007.08.014;
RA   Paderova, Jana
RA   Orlic-Milacic, Marija
RA   Yoshimoto, Maisa
RA   da Cunha Santos, Gilda
RA   Gallie, Brenda Louise
RA   Squire, Jeremy Andrew
RT   "Novel 6p rearrangements and recurrent translocation breakpoints in
RT   retinoblastoma cell lines identified by spectral karyotyping and mBAND
RT   analyses.";
RL   Cancer Genet. Cytogenet. 179:102-111(2007).
//
RX   PubMed=30584916; DOI=10.1016/j.yexcr.2018.12.018;
RA   Schwermer, Melanie
RA   Hiber, Michaela
RA   Dreesmann, Sabine
RA   Rieb, Anja
RA   Theissen, Jessica
RA   Herold, Thomas
RA   Schramm, Alexander
RA   Temming, Petra
RA   Steenpass, Laura
RT   "Comprehensive characterization of RB1 mutant and MYCN amplified
RT   retinoblastoma cell lines.";
RL   Exp. Cell Res. 375:92-99(2019).
//
RX   CelloPub=CLPUB00447;
RA   Mulivor, Richard A.
RA   Suchy, Sharon F.
RT   "1992/1993 catalog of cell lines. NIGMS human genetic mutant cell
RT   repository. 16th edition. October 1992.";
RL   (In misc. document) Institute for Medical Research (Camden, N.J.) NIH 92-2011; pp.1-918; National Institutes of Health; Bethesda; USA (1992).
//
RX   PubMed=7689221; DOI=10.1073/pnas.90.16.7578; PMCID=PMC47185;
RA   Godbout, Roseline
RA   Squire, Jeremy Andrew
RT   "Amplification of a DEAD box protein gene in retinoblastoma cell
RT   lines.";
RL   Proc. Natl. Acad. Sci. U.S.A. 90:7578-7582(1993).
//
RX   PubMed=4135597; DOI=10.1093/jnci/53.2.347;
RA   Reid, Ted W.
RA   Albert, Daniel M.
RA   Rabson, Alan Saul
RA   Russell, Paul
RA   Craft, Joseph L.
RA   Chu, Elizabeth W.
RA   Tralka, Tommie Sue
RA   Wilcox, Janice L.
RT   "Characteristics of an established cell line of retinoblastoma.";
RL   J. Natl. Cancer Inst. 53:347-360(1974).
//
RX   PubMed=32123578; DOI=10.1038/s41420-020-0237-8; PMCID=PMC7026052;
RA   Aubry, Arthur
RA   Yu, Tao
RA   Bremner, Rod
RT   "Preclinical studies reveal MLN4924 is a promising new retinoblastoma
RT   therapy.";
RL   Cell Death Discov. 6:2.1-2.12(2020).
//
RX   PubMed=3518877; DOI=10.3109/07357908609038260;
RA   Fogh, Jorgen
RT   "Human tumor lines for cancer research.";
RL   Cancer Invest. 4:157-184(1986).
//
RX   PubMed=3413073; DOI=10.1073/pnas.85.16.6017; PMCID=PMC281896;
RA   Lee, Eva Y.-H.P.
RA   Bookstein, Robert
RA   Young, Lih-Jiuan
RA   Lin, Chi-Jen
RA   Rosenfeld, Michael Geoffrey
RA   Lee, Wen-Hwa
RT   "Molecular mechanism of retinoblastoma gene inactivation in
RT   retinoblastoma cell line Y79.";
RL   Proc. Natl. Acad. Sci. U.S.A. 85:6017-6021(1988).
//
RX   PubMed=29192327; DOI=10.3892/or.2017.6100; PMCID=PMC5783599;
RA   Busch, Maike Anna
RA   Papior, David
RA   Stephan, Harald
RA   Dunker, Nicole
RT   "Characterization of etoposide- and cisplatin-chemoresistant
RT   retinoblastoma cell lines.";
RL   Oncol. Rep. 39:160-172(2018).
//
RX   PubMed=27050416; DOI=10.1371/journal.pone.0153011; PMCID=PMC4822873;
RA   Ferrario, Angela
RA   Luna, Marian C.
RA   Rucker, Natalie
RA   Wong, Sam
RA   Lederman, Ariel
RA   Kim, Jonathan
RA   Gomer, Charles Joseph
RT   "Targeting survivin enhances chemosensitivity in retinoblastoma cells
RT   and orthotopic tumors.";
RL   PLoS ONE 11:e0153011.1-e0153011.16(2016).
//
RX   PubMed=23498719; DOI=10.1016/S1470-2045(13)70045-7;
RA   Rushlow, Diane E.
RA   Mol, Berber M.
RA   Kennett, Jennifer Y.
RA   Yee, Stephanie
RA   Pajovic, Sanja
RA   Theriault, Brigitte L.
RA   Prigoda-Lee, Nadia L.
RA   Spencer, Clarellen
RA   Dimaras, Helen
RA   Corson, Timothy W.
RA   Pang, Renee
RA   Massey, Christine
RA   Godbout, Roseline
RA   Jiang, Zhe
RA   Zacksenhaus, Eldad
RA   Paton, Katherine
RA   Moll, Annette C.
RA   Houdayer, Claude
RA   Raizis, Anthony
RA   Halliday, William
RA   Lam, Wan L.
RA   Boutros, Paul Christopher
RA   Lohmann, Dietmar R.
RA   Dorsman, Josephine Christine
RA   Gallie, Brenda Louise
RT   "Characterisation of retinoblastomas without RB1 mutations: genomic,
RT   gene expression, and clinical studies.";
RL   Lancet Oncol. 14:327-334(2013).
//
RX   PubMed=6167750; DOI=10.1093/jnci/67.2.301;
RA   Gilbert, Fred
RA   Balaban-Malenbaum, Gloria Brady
RA   Breg, William Roy
RA   Gallie, Brenda Louise
RA   Reid, Ted W.
RA   Nichols, Warren W.
RT   "Homogeneously staining region in a retinoblastoma cell line:
RT   relevance to tumor initiation and progression.";
RL   J. Natl. Cancer Inst. 67:301-306(1981).
//
RX   PubMed=21697133; DOI=10.1167/iovs.11-7479;
RA   Oshikawa, Mio
RA   Tsutsui, Chihiro
RA   Ikegami, Tomoko
RA   Fuchida, Yuki
RA   Matsubara, Maki
RA   Toyama, Shigeru
RA   Usami, Ron
RA   Ohtoko, Kuniyo
RA   Kato, Seishi
RT   "Full-length transcriptome analysis of human retina-derived cell lines
RT   ARPE-19 and Y79 using the vector-capping method.";
RL   Invest. Ophthalmol. Vis. Sci. 52:6662-6670(2011).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662;
RA   Rothenberg, S. Michael
RA   Mohapatra, Gayatry
RA   Rivera, Miguel N.
RA   Winokur, Daniel
RA   Greninger, Patricia
RA   Nitta, Mai
RA   Sadow, Peter M.
RA   Sooriyakumar, Gaya
RA   Brannigan, Brian W.
RA   Ulman, Matthew J.
RA   Perera, Rushika M.
RA   Wang, Rui
RA   Tam, Angela
RA   Ma, Xiao-Jun
RA   Erlander, Mark
RA   Sgroi, Dennis C.
RA   Rocco, James W.
RA   Lingen, Mark W.
RA   Cohen, Ezra E.W.
RA   Louis, David Neil
RA   Settleman, Jeffrey
RA   Haber, Daniel Arie
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//