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Cellosaurus FaDu (CVCL_1218)

[Text version]
Cell line name FaDu
Synonyms FaDU; FADU; JHU-SCC-FaDu
Accession CVCL_1218
Resource Identification Initiative To cite this cell line use: FaDu (RRID:CVCL_1218)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: KuDOS 95 cell line panel.
Part of: MD Anderson Cell Lines Project.
Population: Indian.
Doubling time: ~50 hours (Note=At 16th passage) (PubMed=4332311); 48.1 hours (PubMed=21314983); ~30 hours (DSMZ=ACC-784).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Genomics; Whole genome sequencing; Low read coverage.
Omics: Phenotyping; CRISPR screening.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Pharynx, hypopharynx; UBERON=UBERON_0001051.
Cell type: Epithelial cell; CL=CL_0000066.
Sequence variations
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; c.151-1G>T; ClinVar=VCV000422058; Zygosity=Homozygous; Note=Splice acceptor mutation (ATCC=HTB-43; Cosmic-CLP=906863; DepMap=ACH-000846).
  • Mutation; HGNC; HGNC:3595; FAT1; Simple; p.Lys3277Asnfs*4 (c.9828delG) (p.Gly3276fs); Zygosity=Heterozygous (Cosmic-CLP=906863; DepMap=ACH-000846).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; c.376-1G>A (p.Tyr126_Lys132del, c.376_396del21); ClinVar=VCV000481003; Zygosity=Heterozygous; Note=Splice acceptor mutation (PubMed=1394225; PubMed=11799138; PubMed=23613873; ATCC=HTB-43; Cosmic-CLP=906863; DepMap=ACH-000846).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Leu (c.743G>T); ClinVar=VCV000230253; Zygosity=Heterozygous (PubMed=1394225; PubMed=11799138; PubMed=23613873; ATCC=HTB-43; Cosmic-CLP=906863; DepMap=ACH-000846).
HLA typing Source: PubMed=26589293
Class I
HLA-AA*01:01,01:01
HLA-BB*15:17,37:04
HLA-CC*07:01,07:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African2.06
Native American0
East Asian, North11.01
East Asian, South0
South Asian79.51
European, North0
European, South7.42
Disease Hypopharyngeal squamous cell carcinoma (NCIt: C4043)
Squamous cell carcinoma of the hypopharynx (ORDO: Orphanet_494547)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_EI27 (ER-Fadu)CVCL_0D71 (FaDu 2A3)CVCL_E8SL (FaDu ATM KO clone 1B5)
CVCL_E8SM (FaDu ATM KO clone 1B6)CVCL_E8FQ (FaDu Fat-1)CVCL_VP44 (FaDu(DD))
CVCL_A4CG (FaDu-Luc2)CVCL_SA75 (FaDu-R)CVCL_D5YF (FaDu/DDP4)
CVCL_EG58 (FaDu/T)CVCL_5988 (JHU-013)
Sex of cell Male
Age at sampling 56Y
Category Cancer cell line
STR profile Source(s): ATCC=HTB-43; Cosmic-CLP=906863; DSMZ=ACC-784; KCLB=30043; PubMed=21868764; PubMed=25877200; PubMed=33802339; PubMed=36912284; Technion Genomics Center

Markers:
AmelogeninX (KCLB=30043)
Not_detected (ATCC=HTB-43; Cosmic-CLP=906863; DSMZ=ACC-784; PubMed=21868764; PubMed=25877200; PubMed=33802339; PubMed=36912284; Technion Genomics Center)
CSF1PO12
D1S165616,16.3
D2S44111
D2S133819
D3S135817,18
D5S81812
D7S82011,12
D8S117913
D10S124815,17
D12S39117,21
D13S3178,9 (ATCC=HTB-43; PubMed=21868764; PubMed=25877200; PubMed=33802339; PubMed=36912284; Technion Genomics Center)
9 (DSMZ=ACC-784)
D16S53911 (ATCC=HTB-43; Cosmic-CLP=906863; PubMed=21868764; PubMed=25877200; PubMed=33802339; PubMed=36912284; Technion Genomics Center)
11,12 (DSMZ=ACC-784)
D18S5116
D19S43314,16
D21S1131 (DSMZ=ACC-784)
31.2 (ATCC=HTB-43; PubMed=25877200; PubMed=33802339; Technion Genomics Center)
D22S104511
FGA25
Penta D11
Penta E17,19
TH018
TPOX11
vWA15,17 (ATCC=HTB-43; Cosmic-CLP=906863; KCLB=30043; PubMed=21868764; PubMed=25877200; PubMed=36912284; Technion Genomics Center)
15,17,18 (DSMZ=ACC-784; PubMed=33802339)

Run an STR similarity search on this cell line
Web pages Info; MCLP; -; https://tcpaportal.org/mclp/
Provider; Altogen; Xenograft model; https://altogenlabs.com/xenograft-models/other-bladder-cervical/fadu-xenograft-model/
Publications

PubMed=4332311; DOI=10.1002/1097-0142(197201)29:1<117::AID-CNCR2820290119>3.0.CO;2-R
Setlur Ramaswami S. Rangan;
A new human cell line (FaDu) from a hypopharyngeal carcinoma.
Cancer 29:117-121(1972)

PubMed=327080; DOI=10.1093/jnci/59.1.221
Jorgen Fogh, Jens M. Fogh, Thomas Orfeo;
One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice.
J. Natl. Cancer Inst. 59:221-226(1977)

PubMed=833871; DOI=10.1093/jnci/58.2.209
Jorgen Fogh, William C. Wright, James D. Loveless;
Absence of HeLa cell contamination in 169 cell lines derived from human tumors.
J. Natl. Cancer Inst. 58:209-214(1977)

PubMed=6935474; DOI=10.1093/jnci/66.2.239
William C. Wright, Walter P. Daniels, Jorgen Fogh;
Distinction of seventy-one cultured human tumor cell lines by polymorphic enzyme analysis.
J. Natl. Cancer Inst. 66:239-247(1981)

PubMed=7459858
Monique Rousset, Alain Zweibaum, Jorgen Fogh;
Presence of glycogen and growth-related variations in 58 cultured human tumor cell lines of various tissue origins.
Cancer Res. 41:1165-1170(1981)

PubMed=2990217; PMCID=PMC1888002
Carole Yee, Indira Krishnan-Hewlett, Carl C. Baker, Richard Schlegel, Peter Maxwell Howley;
Presence and expression of human papillomavirus sequences in human cervical carcinoma cell lines.
Am. J. Pathol. 119:361-366(1985)

PubMed=3518877; DOI=10.3109/07357908609038260
Jorgen Fogh;
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

PubMed=3138611; DOI=10.1177/019459988809800603
Thomas P.U. Wustrow, Alexander Raffael, Gunter K. Valet;
Multiparametric flow cytometry of human squamous cell carcinoma lines from the head and neck.
Otolaryngol. Head Neck Surg. 98:552-557(1988)

PubMed=1394225
Kenneth D. Somers, M. Anne Merrick, Martha E. Lopez, Leonard S. Incognito, Gary L. Schechter, Graham Casey;
Frequent p53 mutations in head and neck cancer.
Cancer Res. 52:5997-6000(1992)

DOI=10.1016/B978-0-12-333530-2.50007-1
Thomas E. Carey;
Head and neck tumor cell lines.
(In book chapter) Atlas of human tumor cell lines; Hay, Robert J. & Park, Jae-Gahb & Gazdar, Adi F. (eds.); pp.79-120; Academic Press; New York; USA (1994)

PubMed=8552396
Ankita M. Patel, Leonard S. Incognito, Gary L. Schechter, William J. Wasilenko, Kenneth D. Somers;
Amplification and expression of EMS-1 (cortactin) in head and neck squamous cell carcinoma cell lines.
Oncogene 12:31-35(1996)

PubMed=9815580
Yang-Guan Wu, Ann J. Palad, William J. Wasilenko, Peter F. Blackmore, William A. Pincus, Gary L. Schechter, Joseph R. Spoonster, Elise C. Kohn, Kenneth D. Somers;
Inhibition of head and neck squamous cell carcinoma growth and invasion by the calcium influx inhibitor carboxyamido-triazole.
Clin. Cancer Res. 3:1915-1921(1997)

PubMed=11799138; DOI=10.1177/002215540205000207
Wolfgang Eicheler, Daniel Zips, Annegret Dorfler, Reidar Grenman, Michael Baumann;
Splicing mutations in TP53 in human squamous cell carcinoma lines influence immunohistochemical detection.
J. Histochem. Cytochem. 50:197-204(2002)

PubMed=17848307; DOI=10.1016/j.ijrobp.2007.04.082
Wendell Gray Yarbrough, Amy Whigham, Brandee Brown, Michael Roach, Robbert J.C. Slebos;
Phosphoinositide kinase-3 status associated with presence or absence of human papillomavirus in head and neck squamous cell carcinomas.
Int. J. Radiat. Oncol. Biol. Phys. 69:S98-S101(2007)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=21314983; DOI=10.1186/1758-3284-3-9; PMCID=PMC3046925
Matthew Harris, Xing-Guo Wang, Ze-Wei Jiang, Gary L. Goldberg, Arturo Casadevall, Ekaterina Dadachova;
Radioimmunotherapy of experimental head and neck squamous cell carcinoma (HNSCC) with E6-specific antibody using a novel HPV-16 positive HNSCC cell line.
Head Neck Oncol. 3:9.1-9.7(2011)

PubMed=21833476; DOI=10.3892/or.2011.1418
Ju-Ke Ma, Su-Mei Lu, Liang Yu, Jia-Jun Tian, Jian-Feng Li, Hai-Bo Wang, Wei Xu;
FaDu cell characteristics induced by multidrug resistance.
Oncol. Rep. 26:1189-1195(2011)

PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690; PMCID=PMC3229662
Mei Zhao, Daisuke Sano, Curtis R. Pickering, Samar A. Jasser, Ying C. Henderson, Gary L. Clayman, Erich M. Sturgis, Thomas J. Ow, Reuben Lotan, Thomas E. Carey, Peter G. Sacks ...Show all 15 authors... , Jennifer Rubin Grandis, David Sidransky, Nils-Erik Heldin, Jeffrey N. Myers; Show fewer authors
Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.
Clin. Cancer Res. 17:7248-7264(2011)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=23613873; DOI=10.1371/journal.pone.0061555; PMCID=PMC3629194
Sanne R. Martens-de Kemp, Simone U. Dalm, Fiona M.J. Wijnolts, Arjen Brink, Richard J. Honeywell, Godefridus Johannes Peters, Boudewijn J.M. Braakhuis, Ruud H. Brakenhoff;
DNA-bound platinum is the major determinant of cisplatin sensitivity in head and neck squamous carcinoma cells.
PLoS ONE 8:e61555.1-e61555.9(2013)

PubMed=25485619; DOI=10.1038/nbt.3080
Christiaan Klijn, Steffen Durinck, Eric W. Stawiski, Peter M. Haverty, Zhao-Shi Jiang, Han-Bin Liu, Jeremiah Degenhardt, Oleg Mayba, Florian Gnad, Jin-Feng Liu, Gregoire Pau ...Show all 30 authors... , Jens Reeder, Yi Cao, Kiran Mukhyala, Suresh K. Selvaraj, Ma-Mie Yu, Gregory J. Zynda, Matthew J. Brauer, Thomas D. Wu, Robert Clifford Gentleman, Gerard Manning, Robert L. Yauch, Richard Bourgon, David Stokoe, Zora Modrusan, Richard M. Neve, Frederic J. de Sauvage, Jeffrey Settleman, Somasekar Seshagiri, Ze-Min Zhang; Show fewer authors
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=25888065; DOI=10.1016/j.molonc.2015.03.008; PMCID=PMC4523436
Aditya Stanam, Laurie Love-Homan, Tisha S. Joseph, Madelyn Espinosa-Cotton, Andrean L. Simons;
Upregulated interleukin-6 expression contributes to erlotinib resistance in head and neck squamous cell carcinoma.
Mol. Oncol. 9:1371-1383(2015)

PubMed=26122845; DOI=10.1158/0008-5472.CAN-15-0528
Chantal Stoepker, Najim Ameziane, Petra van der Lelij, Irsan E. Kooi, Anneke B. Oostra, Martin A. Rooimans, Saskia E. van Mil, Arjen Brink, Ralf Dietrich, Jesper A. Balk, Bauke Ylstra ...Show all 14 authors... , Hans Joenje, Stephan M. Feller, Ruud H. Brakenhoff; Show fewer authors
Defects in the Fanconi anemia pathway and chromatid cohesion in head and neck cancer.
Cancer Res. 75:3543-3553(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

CLPUB00484
Zhi-Hong Xu, Wen-Wen Sun, Jun-Biao Hang, Bei-Li Gao, Jia-An Hu;
RNA-seq identified a novel functional MET fusion in head and neck cancer 5-8F cell line.
Int. J. Clin. Exp. Pathol. 9:8308-8317(2016)

PubMed=26754630; DOI=10.1186/s13046-016-0284-4; PMCID=PMC4709939
Hiroshi Hyakusoku, Daisuke Sano, Hideaki Takahashi, Takashi Hatano, Yasuhiro Isono, Shoko Shimada, Yusuke Ito, Jeffrey N. Myers, Nobuhiko Oridate;
JunB promotes cell invasion, migration and distant metastasis of head and neck squamous cell carcinoma.
J. Exp. Clin. Cancer Res. 35:6.1-6.12(2016)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, A. Karina Eterovic, Lauren Averett Byers ...Show all 25 authors... , Michael A. Davies, Wan-Leng Deng, Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=28476783; DOI=10.21873/anticanres.11555
Jan Hagemann, Christian Jacobi, Moritz Hahn, Vanessa Schmid, Christian Welz, Sabina Schwenk-Zieger, Roland H. Stauber, Philipp Baumeister, Sven Becker;
Spheroid-based 3D cell cultures enable personalized therapy testing and drug discovery in head and neck cancer.
Anticancer Res. 37:2201-2210(2017)

PubMed=29156801; DOI=10.18632/oncotarget.21174; PMCID=PMC5689691
Nene N. Kalu, Tuhina Mazumdar, Shao-Hua Peng, Li Shen, Vaishnav Sambandam, Xia-Yu Rao, Yuan-Xin Xi, Le-Rong Li, Yuan Qi, Frederico O. Gleber-Netto, Ameeta Patel ...Show all 16 authors... , Jing Wang, Mitchell J. Frederick, Jeffrey N. Myers, Curtis R. Pickering, Faye M. Johnson; Show fewer authors
Genomic characterization of human papillomavirus-positive and -negative human squamous cell cancer cell lines.
Oncotarget 8:86369-86383(2017)

PubMed=28844650; DOI=10.1016/j.anl.2017.07.011
Kwang-Jae Cho, Eun-Ji Park, Min-Sik Kim, Young-Hoon Joo;
Characterization of FaDu-R, a radioresistant head and neck cancer cell line, and cancer stem cells.
Auris Nasus Larynx 45:566-573(2018)

PubMed=30135316; DOI=10.1172/jci.insight.122204; PMCID=PMC6141174
Stephen M.F. Jamieson, Peter Tsai, Maria K. Kondratyev, Pratha Budhani, Arthur Liu, Neil N. Senzer, E. Gabriela Chiorean, Shadia I. Jalal, John Joseph Nemunaitis, Dennis Kee, Avik Shome ...Show all 35 authors... , Way W. Wong, Dan Li, Nooriyah Poonawala-Lohani, Purvi M. Kakadia, Nicholas S. Knowlton, Courtney R.H. Lynch, Cho R. Hong, Tet Woo Lee, Reidar Grenman, Laura Caporiccio, Trevor David McKee, Mark Zaidi, Sehrish Butt, Andrew M.J. Macann, Nicholas P. McIvor, John M. Chaplin, Kevin O. Hicks, Stefan Klaus Bohlander, Bradly G. Wouters, Charles P. Hart, Cristin Gregor Print, William R. Wilson, Michael A. Curran, Francis W. Hunter; Show fewer authors
Evofosfamide for the treatment of human papillomavirus-negative head and neck squamous cell carcinoma.
JCI Insight 3:e122204.1-e122204.19(2018)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=30971826; DOI=10.1038/s41586-019-1103-9
Fiona M. Behan, Francesco Iorio, Gabriele Picco, Emanuel Goncalves, Charlotte M. Beaver, Giorgia Migliardi, Rita Santos, Yanhua Rao, Francesco Sassi, Marika Pinnelli, Rizwan Ansari ...Show all 25 authors... , Sarah Harper, David Adam Jackson, Rebecca McRae, Rachel Pooley, Piers Wilkinson, Dieudonne J. van der Meer, David Dow, Carolyn A. Buser-Doepner, Andrea Bertotti, Livio Trusolino, Euan Alexander Stronach, Julio Saez-Rodriguez, Kosuke Yusa, Mathew J. Garnett; Show fewer authors
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Nature 568:511-516(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31541927; DOI=10.1016/j.oraloncology.2019.09.004; PMCID=PMC7372097
Anne M. van Harten, Jos B. Poell, Marijke Buijze, Arjen Brink, Susanne I. Wells, C. Rene Leemans, Rob M.F. Wolthuis, Ruud H. Brakenhoff;
Characterization of a head and neck cancer-derived cell line panel confirms the distinct TP53-proficient copy number-silent subclass.
Oral Oncol. 98:53-61(2019)

PubMed=31978347; DOI=10.1016/j.cell.2019.12.023; PMCID=PMC7339254
David Paul Nusinow, John Szpyt, Mahmoud Ghandi, Christopher M. Rose, E. Robert McDonald 3rd, Marian Kalocsay, Judit Jane-Valbuena, Ellen T. Gelfand, Devin K. Schweppe, Mark P. Jedrychowski, Javad Golji ...Show all 20 authors... , Dale A. Porter, Tomas Rejtar, Y. Karen Wang, Gregory V. Kryukov, Frank Stegmeier, Brian K. Erickson, Levi Alexander Garraway, William Raj Sellers, Steven P. Gygi; Show fewer authors
Quantitative proteomics of the Cancer Cell Line Encyclopedia.
Cell 180:387-402.e16(2020)

PubMed=33802339; DOI=10.3390/cancers13051069; PMCID=PMC7959143
Eva-Leonne Gottgens, Marleen Ansems, William P.J. Leenders, Johan Bussink, Paul N. Span;
Genotyping and characterization of HPV status, hypoxia, and radiosensitivity in 22 head and neck cancer cell lines.
Cancers (Basel) 13:1069.1-1069.12(2021)

PubMed=34249502; DOI=10.7717/peerj.11645; PMCID=PMC8255068
Ge-Hou Zhang, Guo-Lin Tan, Tie-Qi Li, Jin-Gang Ai, Ye-Xun Song, Zheng Zhou, Jian Xiao, Wei Li;
Analysis of ceRNA network of differentially expressed genes in FaDu cell line and a cisplatin-resistant line derived from it.
PeerJ 9:e11645.1-e11645.15(2021)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

PubMed=36912284; DOI=10.1002/ijc.34506
Hiep Tai Nguyen, Wei-Liang Tang, Andrew L.H. Webster, Jeffrey R. Whiteaker, Christopher M. Chandler, Ricardo Errazquin Ciudad, Khashayar Roohollahi, Madeline Fritzke, Elizabeth E. Hoskins, Erica C. Jonlin, Leslie Wakefield ...Show all 21 authors... , Lucas B. Sullivan, Eleanor Y. Chen, Josephine C. Dorsman, Ruud H. Brakenhoff, Amanda Grace Paulovich, Markus Grompe, Ramon Garcia-Escudero, Susanne I. Wells, Agata Smogorzewska, Raymond J. Monnat Jr.; Show fewer authors
Fanconi anemia-isogenic head and neck cancer cell line pairs: a basic and translational science resource.
Int. J. Cancer 153:183-196(2023)

Cross-references
Cell line collections (Providers) ATCC; HTB-43
BCRC; 60214
BCRJ; 0301
CLS; 305033
DSMZ; ACC-784
KCLB; 30043
Cell line databases/resources CLO; CLO_0002993
cancercelllines; CVCL_1218
CCRID; 3101HUMTCHu132
Cell_Model_Passport; SIDM00860
Cosmic-CLP; 906863
DepMap; ACH-000846
DSMZCellDive; ACC-784
IGRhCellID; FaDu
LINCS_LDP; LCL-1201
Anatomy/cell type resources BTO; BTO_0003233
Biological sample resources BioSample; SAMN03471972
BioSample; SAMN10987898
CRISP screens repositories BioGRID_ORCS_Cell_line; 676
Chemistry resources ChEMBL-Cells; CHEMBL3307943
ChEMBL-Targets; CHEMBL612250
GDSC; 906863
PharmacoDB; FADU_365_2019
PubChem_Cell_line; CVCL_1218
Encyclopedic resources Wikidata; Q54833221
Experimental variables resources EFO; EFO_0002178
Gene expression databases ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
GEO; GSM482707
GEO; GSM482708
GEO; GSM482709
GEO; GSM482710
GEO; GSM887011
GEO; GSM888080
GEO; GSM1374479
GEO; GSM1374480
GEO; GSM1524310
GEO; GSM1524311
GEO; GSM1524312
GEO; GSM1669791
GEO; GSM5104698
GEO; GSM5104717
Polymorphism and mutation databases Cosmic; 686975
Cosmic; 906863
Cosmic; 921832
Cosmic; 1006466
Cosmic; 1017792
Cosmic; 1122668
Cosmic; 1339914
Cosmic; 1530736
Cosmic; 1752764
Cosmic; 2301587
Cosmic; 2592979
Cosmic; 2646650
Cosmic; 2668290
IARC_TP53; 1681
LiGeA; CCLE_224
Progenetix; CVCL_1218
Proteomic databases PRIDE; PXD002132
PRIDE; PXD002486
PRIDE; PXD030304
Sequence databases EGA; EGAS00001000610
EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number49