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Cellosaurus FaDu 2A3 (CVCL_0D71)

[Text version]
Cell line name FaDu 2A3
Synonyms 2A3
Accession CVCL_0D71
Resource Identification Initiative To cite this cell line use: FaDu 2A3 (RRID:CVCL_0D71)
Comments Population: Indian.
Doubling time: 51.8 hours (PubMed=21314983); ~51 hours (ATCC=CRL-3212).
Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Derived from site: In situ; Pharynx, hypopharynx; UBERON=UBERON_0001051.
Cell type: Epithelial cell; CL=CL_0000066.
Sequence variations
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; c.151-1G>T; ClinVar=VCV000422058; Zygosity=Homozygous; Note=Splice acceptor mutation (from parent cell line).
  • Mutation; HGNC; HGNC:3595; FAT1; Simple; p.Lys3277Asnfs*4 (c.9828delG) (p.Gly3276fs); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; c.376-1G>A (p.Tyr126_Lys132del, c.376_396del21); ClinVar=VCV000481003; Zygosity=Heterozygous; Note=Splice acceptor mutation (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Leu (c.743G>T); ClinVar=VCV000230253; Zygosity=Heterozygous (from parent cell line).
Disease Hypopharyngeal squamous cell carcinoma (NCIt: C4043)
Squamous cell carcinoma of the hypopharynx (ORDO: Orphanet_494547)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1218 (FaDu)
Sex of cell Male
Age at sampling 56Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-3212

Markers:
AmelogeninNot_detected
CSF1PO12
D5S81812
D7S82011,12
D13S3178,9
D16S53911
TH018
TPOX11
vWA15,17

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Publications

PubMed=21314983; DOI=10.1186/1758-3284-3-9; PMCID=PMC3046925
Matthew Harris, Xing-Guo Wang, Ze-Wei Jiang, Gary L. Goldberg, Arturo Casadevall, Ekaterina Dadachova;
Radioimmunotherapy of experimental head and neck squamous cell carcinoma (HNSCC) with E6-specific antibody using a novel HPV-16 positive HNSCC cell line.
Head Neck Oncol. 3:9.1-9.7(2011)

Cross-references
Cell line collections (Providers) ATCC; CRL-3212
Cell line databases/resources cancercelllines; CVCL_0D71
Encyclopedic resources Wikidata; Q54584291
Entry history
Entry creation10-Apr-2015
Last entry update14-Aug-2025
Version number18