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Cellosaurus FaDu(DD) (CVCL_VP44)

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Cell line name FaDu(DD)
Synonyms FaDuDD; FADUDD; FaDudd; FaDu DD; FADU DD
Accession CVCL_VP44
Resource Identification Initiative To cite this cell line use: FaDu(DD) (RRID:CVCL_VP44)
Comments Population: Indian.
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Pharynx, hypopharynx; UBERON=UBERON_0001051.
Cell type: Epithelial cell; CL=CL_0000066.
Sequence variations
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; c.151-1G>T; ClinVar=VCV000422058; Zygosity=Homozygous; Note=Splice acceptor mutation (from parent cell line).
  • Mutation; HGNC; HGNC:3595; FAT1; Simple; p.Lys3277Asnfs*4 (c.9828delG) (p.Gly3276fs); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; c.376-1G>A (p.Tyr126_Lys132del, c.376_396del21); ClinVar=VCV000481003; Zygosity=Hemizygous; Note=Splice acceptor mutation (PubMed=11799138).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Leu (c.743G>T); ClinVar=VCV000230253; Zygosity=Heterozygous (from parent cell line).
Disease Hypopharyngeal squamous cell carcinoma (NCIt: C4043)
Squamous cell carcinoma of the hypopharynx (ORDO: Orphanet_494547)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1218 (FaDu)
Sex of cell Male
Age at sampling 56Y
Category Cancer cell line
Publications

PubMed=11799138; DOI=10.1177/002215540205000207
Wolfgang Eicheler, Daniel Zips, Annegret Dorfler, Reidar Grenman, Michael Baumann;
Splicing mutations in TP53 in human squamous cell carcinoma lines influence immunohistochemical detection.
J. Histochem. Cytochem. 50:197-204(2002)

PubMed=20429727; DOI=10.3109/02841861003614343
Brita Singers Sorensen, Kasper Toustrup, Michael R. Horsman, Jens Overgaard, Jan Alsner;
Identifying pH independent hypoxia induced genes in human squamous cell carcinomas in vitro.
Acta Oncol. 49:895-905(2010)

Cross-references
Cell line databases/resources cancercelllines; CVCL_VP44
Encyclopedic resources Wikidata; Q93549515
Gene expression databases GEO; GSM1716417
GEO; GSM1716418
GEO; GSM1716419
GEO; GSM1716420
GEO; GSM1716421
GEO; GSM1716422
GEO; GSM1716427
GEO; GSM1716428
GEO; GSM1716429
GEO; GSM1716430
Entry history
Entry creation07-Sep-2018
Last entry update14-Aug-2025
Version number14