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Cellosaurus JHU-013 (CVCL_5988)

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Cell line name JHU-013
Synonyms JHU 013; JHU013; JHU-O13; JHU-13; O13; Johns Hopkins University-013
Accession CVCL_5988
Resource Identification Initiative To cite this cell line use: JHU-013 (RRID:CVCL_5988)
Comments Problematic cell line: Contaminated. Shown to be a FaDu derivative (PubMed=21868764).
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00404.
Population: Indian.
Derived from site: In situ; Pharynx, hypopharynx; UBERON=UBERON_0001051.
Cell type: Epithelial cell; CL=CL_0000066.
Sequence variations
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; c.151-1G>T; ClinVar=VCV000422058; Zygosity=Homozygous; Note=Splice acceptor mutation (from parent cell line).
  • Mutation; HGNC; HGNC:3595; FAT1; Simple; p.Lys3277Asnfs*4 (c.9828delG) (p.Gly3276fs); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; c.376-1G>A (p.Tyr126_Lys132del, c.376_396del21); ClinVar=VCV000481003; Zygosity=Heterozygous; Note=Splice acceptor mutation (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Leu (c.743G>T); ClinVar=VCV000230253; Zygosity=Heterozygous (from parent cell line).
Disease Hypopharyngeal squamous cell carcinoma (NCIt: C4043)
Squamous cell carcinoma of the hypopharynx (ORDO: Orphanet_494547)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1218 (FaDu)
Sex of cell Male
Age at sampling 56Y
Category Cancer cell line
STR profile Source(s): PubMed=21868764

Markers:
AmelogeninNot_detected
CSF1PO12
D5S81812
D7S82011,12
D13S3178,9
D16S53911
TH018
TPOX11
vWA15,17

Run an STR similarity search on this cell line
Web pages Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=12925955; DOI=10.1002/ijc.11341
Khalid M. Minhas, Bhuvanesh Singh, Wei-Wen Jiang, David Sidransky, Joseph A. Califano 3rd;
Spindle assembly checkpoint defects and chromosomal instability in head and neck squamous cell carcinoma.
Int. J. Cancer 107:46-52(2003)

PubMed=12963126; DOI=10.1016/S0304-3835(03)00344-6
Mohammad Obaidul Hoque, Shahnaz Begum, Matthias Sommer, Taekyeol Lee, Barry Trink, Edward Ratovitski, David Sidransky;
PUMA in head and neck cancer.
Cancer Lett. 199:75-81(2003)

PubMed=17848307; DOI=10.1016/j.ijrobp.2007.04.082
Wendell Gray Yarbrough, Amy Whigham, Brandee Brown, Michael Roach, Robbert J.C. Slebos;
Phosphoinositide kinase-3 status associated with presence or absence of human papillomavirus in head and neck squamous cell carcinomas.
Int. J. Radiat. Oncol. Biol. Phys. 69:S98-S101(2007)

PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690; PMCID=PMC3229662
Mei Zhao, Daisuke Sano, Curtis R. Pickering, Samar A. Jasser, Ying C. Henderson, Gary L. Clayman, Erich M. Sturgis, Thomas J. Ow, Reuben Lotan, Thomas E. Carey, Peter G. Sacks ...Show all 15 authors... , Jennifer Rubin Grandis, David Sidransky, Nils-Erik Heldin, Jeffrey N. Myers; Show fewer authors
Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.
Clin. Cancer Res. 17:7248-7264(2011)

Cross-references
Cell line databases/resources cancercelllines; CVCL_5988
Anatomy/cell type resources BTO; BTO_0003890
Biological sample resources BioSample; SAMN03151639
Chemistry resources PharmacoDB; JHU013_693_2019
Encyclopedic resources Wikidata; Q54898669
Polymorphism and mutation databases Cosmic; 1122670
Cosmic; 1530747
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number32