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Cellosaurus ER-Fadu (CVCL_EI27)

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Cell line name ER-Fadu
Accession CVCL_EI27
Resource Identification Initiative To cite this cell line use: ER-Fadu (RRID:CVCL_EI27)
Comments Population: Indian.
Selected for resistance to: ChEBI; CHEBI_114785; Erlotinib.
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Pharynx, hypopharynx; UBERON=UBERON_0001051.
Cell type: Epithelial cell; CL=CL_0000066.
Sequence variations
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; c.151-1G>T; ClinVar=VCV000422058; Zygosity=Homozygous; Note=Splice acceptor mutation (from parent cell line).
  • Mutation; HGNC; HGNC:3595; FAT1; Simple; p.Lys3277Asnfs*4 (c.9828delG) (p.Gly3276fs); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; c.376-1G>A (p.Tyr126_Lys132del, c.376_396del21); ClinVar=VCV000481003; Zygosity=Heterozygous; Note=Splice acceptor mutation (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Leu (c.743G>T); ClinVar=VCV000230253; Zygosity=Heterozygous (from parent cell line).
Disease Hypopharyngeal squamous cell carcinoma (NCIt: C4043)
Squamous cell carcinoma of the hypopharynx (ORDO: Orphanet_494547)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1218 (FaDu)
Sex of cell Male
Age at sampling 56Y
Category Cancer cell line
Publications

PubMed=25888065; DOI=10.1016/j.molonc.2015.03.008; PMCID=PMC4523436
Aditya Stanam, Laurie Love-Homan, Tisha S. Joseph, Madelyn Espinosa-Cotton, Andrean L. Simons;
Upregulated interleukin-6 expression contributes to erlotinib resistance in head and neck squamous cell carcinoma.
Mol. Oncol. 9:1371-1383(2015)

Cross-references
Cell line databases/resources cancercelllines; CVCL_EI27
Encyclopedic resources Wikidata; Q54832418
Gene expression databases GEO; GSM1524313
GEO; GSM1524314
GEO; GSM1524315
Entry history
Entry creation26-Sep-2016
Last entry update14-Aug-2025
Version number16