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Cellosaurus FaDu-Luc2 (CVCL_A4CG)

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Cell line name FaDu-Luc2
Accession CVCL_A4CG
Resource Identification Initiative To cite this cell line use: FaDu-Luc2 (RRID:CVCL_A4CG)
Comments Population: Indian.
Characteristics: Stably expresses firefly luciferase under the control of the human EF1a promoter (ATCC=HTB-43-LUC2).
Doubling time: ~30 hours (ATCC=HTB-43-LUC2).
Genetic integration: Method=Transduction; Gene=UniProtKB; P33967; Bacillus cereus Bsr.
Genetic integration: Method=Transduction; Gene=UniProtKB; P08659; Photinus pyralis firefly-type luciferase (Note=With optimized codon usage for mammalian expression = Luc2).
Derived from site: In situ; Pharynx, hypopharynx; UBERON=UBERON_0001051.
Cell type: Epithelial cell; CL=CL_0000066.
Sequence variations
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; c.151-1G>T; ClinVar=VCV000422058; Zygosity=Homozygous; Note=Splice acceptor mutation (from parent cell line).
  • Mutation; HGNC; HGNC:3595; FAT1; Simple; p.Lys3277Asnfs*4 (c.9828delG) (p.Gly3276fs); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; c.376-1G>A (p.Tyr126_Lys132del, c.376_396del21); ClinVar=VCV000481003; Zygosity=Heterozygous; Note=Splice acceptor mutation (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Leu (c.743G>T); ClinVar=VCV000230253; Zygosity=Heterozygous (from parent cell line).
Disease Hypopharyngeal squamous cell carcinoma (NCIt: C4043)
Squamous cell carcinoma of the hypopharynx (ORDO: Orphanet_494547)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1218 (FaDu)
Sex of cell Male
Age at sampling 56Y
Category Cancer cell line
STR profile Source(s): ATCC=HTB-43-LUC2

Markers:
AmelogeninNot_detected
CSF1PO12
D5S81812
D7S82011,12
D13S3178,9
D16S53911
TH018
TPOX11
vWA15,17

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Cross-references
Cell line collections (Providers) ATCC; HTB-43-LUC2
Cell line databases/resources cancercelllines; CVCL_A4CG
Encyclopedic resources Wikidata; Q105506862
Entry history
Entry creation12-Jan-2021
Last entry update14-Aug-2025
Version number11