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Cellosaurus FaDu/DDP4 (CVCL_D5YF)

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Cell line name FaDu/DDP4
Accession CVCL_D5YF
Resource Identification Initiative To cite this cell line use: FaDu/DDP4 (RRID:CVCL_D5YF)
Comments Population: Indian.
Selected for resistance to: ChEBI; CHEBI_27899; Cisplatin (CDDP).
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Pharynx, hypopharynx; UBERON=UBERON_0001051.
Cell type: Epithelial cell; CL=CL_0000066.
Sequence variations
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; c.151-1G>T; ClinVar=VCV000422058; Zygosity=Homozygous; Note=Splice acceptor mutation (from parent cell line).
  • Mutation; HGNC; HGNC:3595; FAT1; Simple; p.Lys3277Asnfs*4 (c.9828delG) (p.Gly3276fs); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; c.376-1G>A (p.Tyr126_Lys132del, c.376_396del21); ClinVar=VCV000481003; Zygosity=Heterozygous; Note=Splice acceptor mutation (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Leu (c.743G>T); ClinVar=VCV000230253; Zygosity=Heterozygous (from parent cell line).
Disease Hypopharyngeal squamous cell carcinoma (NCIt: C4043)
Squamous cell carcinoma of the hypopharynx (ORDO: Orphanet_494547)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1218 (FaDu)
Sex of cell Male
Age at sampling 56Y
Category Cancer cell line
Publications

PubMed=34249502; DOI=10.7717/peerj.11645; PMCID=PMC8255068
Ge-Hou Zhang, Guo-Lin Tan, Tie-Qi Li, Jin-Gang Ai, Ye-Xun Song, Zheng Zhou, Jian Xiao, Wei Li;
Analysis of ceRNA network of differentially expressed genes in FaDu cell line and a cisplatin-resistant line derived from it.
PeerJ 9:e11645.1-e11645.15(2021)

Cross-references
Encyclopedic resources Wikidata; Q127380840
Gene expression databases GEO; GSM5104699
GEO; GSM5104718
Entry history
Entry creation02-May-2024
Last entry update14-Aug-2025
Version number5