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Cellosaurus PLC/PRF/5 (CVCL_0485)

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Cell line name PLC/PRF/5
Synonyms PLC-PRF-5; PLC PRF 5; PLC/PRF5; PLCPRF5; PLC-8024; PLC8024; PLC; Alexander cells; Alexander; Primary Liver Carcinoma/Poliomyelitis Research Foundation/5
Accession CVCL_0485
Secondary accession CVCL_6714
Resource Identification Initiative To cite this cell line use: PLC/PRF/5 (RRID:CVCL_0485)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: JFCR45 cancer cell line panel.
Part of: Liver Cancer Model Repository (LIMORE).
Part of: MD Anderson Cell Lines Project.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-8024.
Population: African; Shangaan.
Virology: Contains at least 7 copies of integrated hepatitis B virus (HBV) genomes. Secretes hepatitis virus B surface antigen (HBsAg) but no other HBV proteins (PubMed=6302689; PubMed=6317496).
Virology: Susceptible to infection by adenovirus types 40 (Ad40) and 41 (Ad41) (PubMed=1317878).
Doubling time: 35-40 hours (PubMed=63998); 20.05-28.76 hours (PubMed=31378681).
Karyotypic information: Has lost chromosome Y.
Transformant: NCBI_TaxID; 10407; Hepatitis B virus (HBV).
Omics: Genomics; Whole exome sequencing.
Omics: Genomics; Whole genome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Proteomics; Subcellular; Secretome.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; miRNA profiling; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Caution: Often called PLC8024 in Chinese literature probably because of a concatenation between PLC/PRF/5 and ATCC-8024.
Misspelling: PCL/PRF/5; Cosmic=873402.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg112Gly (c.334C>G) (p.Pro126Arg, c.377C>G); ClinVar=VCV000233484; Zygosity=Homozygous (PubMed=31378681; DepMap=ACH-001318).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg249Ser (c.747G>T); ClinVar=VCV000012352; Zygosity=Homozygous (PubMed=8224613; PubMed=8389256; DepMap=ACH-001318).
  • Mutation; HGNC; HGNC:12363; TSC2; Simple; p.Asn1651Ser (c.4952A>G); ClinVar=VCV000049335; Zygosity=Homozygous (DepMap=ACH-001318).
HLA typing Source: PubMed=9178645
Class I
HLA-AA*33:02
HLA-BB*42:01,53:01
HLA-CC*04:01,17:01

Source: PubMed=26589293
Class I
HLA-AA*03:01,33:03
HLA-BB*42:02,53:01
HLA-CC*04:01,17:01
Class II
HLA-DQDQB1*06:07,06:07
HLA-DRDRB1*11:73,11:73

Source: CLS=300315
Class I
HLA-AA*03:01:01,09:03:01
HLA-BB*42:02:01,53:01:01
HLA-CC*04:01,04
Class II
HLA-DPDPB1*17,18:01
HLA-DQDQA1*01:03:01,04:01:02
DQB1*03:19:01,06:03:01
HLA-DRDRB1*08:04:01,13:01:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African95.79
Native American0
East Asian, North1.61
East Asian, South0
South Asian0
European, North0
European, South2.59
Disease Adult hepatocellular carcinoma (NCIt: C7956)
Adult hepatocellular carcinoma (ORDO: Orphanet_210159)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_A8RU (N1380)CVCL_B449 (NPLC/PRF/5)CVCL_LJ87 (PLC/PRF/5 Luciferase/GFP)
CVCL_XB32 (PLC/PRF/5-Cas9-705)CVCL_XB33 (PLC/PRF/5-Cas9-706)CVCL_XB34 (PLC/PRF/5-Cas9-707)
CVCL_XB35 (PLC/PRF/5-Cas9-708)CVCL_XB36 (PLC/PRF/5-Cas9-709)CVCL_XB37 (PLC/PRF/5-Cas9-710)
CVCL_XB38 (PLC/PRF/5-Cas9-711)CVCL_XB39 (PLC/PRF/5-Cas9-712)CVCL_XB40 (PLC/PRF/5-Cas9-713)
CVCL_XB41 (PLC/PRF/5-Cas9-714)CVCL_XB42 (PLC/PRF/5-Cas9-715)CVCL_C9DF (PLC/PRF/5/Cas9-hyg)
Sex of cell Male
Age at sampling 24Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-8024; CCRID; CLS=300315; ECACC=85061113; JCRB=IFO50069; JCRB=JCRB0406; KCLB=28024; PubMed=25877200; PubMed=31378681

Markers:
AmelogeninX
CSF1PO10
D1S165614
D2S44112,14
D2S133819 (CLS=300315; PubMed=25877200)
19,22 (ATCC=CRL-8024; CCRID)
D3S135815
D5S81812
D6S104313,21
D7S8209,11
D8S117913,16
D12S39115,20 (CCRID)
20 (CLS=300315; PubMed=25877200)
D13S31711,12
D16S53913
D18S5117
D19S43311,13
D21S1130,33.2
FGA19.2,25
Penta D6,10
Penta E10,16
TH017,8 (CLS=300315; ECACC=85061113; JCRB=IFO50069; JCRB=JCRB0406; KCLB=28024; PubMed=25877200; PubMed=31378681)
8 (ATCC=CRL-8024; CCRID)
TPOX8
vWA15,16

Run an STR similarity search on this cell line
Web pages Info; LCCL; -; https://lccl.zucmanlab.com/hcc/cellLines/PLC.PRF5
Info; MCLP; -; https://tcpaportal.org/mclp/
Provider; BRICS; BRICS0076; http://www.brics.ac.cn/cell/template/cell/cell_detail.html?id=3890
Publications

PubMed=63998
Jennifer J. Alexander, Elke M. Bey, Eric W Geddes, Gerasimos Lecatsas;
Establishment of a continuously growing cell line from primary carcinoma of the liver.
S. Afr. Med. J. 50:2124-2128(1976)

PubMed=184551
Jennifer J. Alexander, Elke M. Bey, J. Michael Whitcutt, James Henderson Sutherland Gear;
Adaptation of cells derived from human malignant tumours to growth in vitro.
S. Afr. J. Med. Sci. 41:89-98(1976)

PubMed=187208; DOI=10.1038/bjc.1976.205; PMCID=PMC2025201
Gwen M. MacNab, Jennifer J. Alexander, Gerasimos Lecatsas, Elke M. Bey, J.M. Urbanowicz;
Hepatitis B surface antigen produced by a human hepatoma cell line.
Br. J. Cancer 34:509-515(1976)

PubMed=6160110; DOI=10.1128/IAI.30.2.607-611.1980; PMCID=PMC551353
Richard J. Daemer, Stephen Mark Feinstone, Jennifer J. Alexander, Joseph G. Tully, William Thomas London, Doris C. Wong, Robert Harry Purcell;
PLC/PRF/5 (Alexander) hepatoma cell line: further characterization and studies of infectivity.
Infect. Immun. 30:607-611(1980)

PubMed=6248960; DOI=10.1126/science.6248960
Barbara B. Knowles, Chin C. Howe, David P. Aden;
Human hepatocellular carcinoma cell lines secrete the major plasma proteins and hepatitis B surface antigen.
Science 209:497-499(1980)

PubMed=6268737; DOI=10.1099/0022-1317-53-1-105
Paul E. Oefinger, David Leigh Bronson, Gordon R. Dreesman;
Induction of hepatitis B surface antigen in human hepatoma-derived cell lines.
J. Gen. Virol. 53:105-113(1981)

PubMed=6275024; DOI=10.1099/0022-1317-57-1-95
Rajen Koshy, Philippe Maupas, R. Muller, Peter Hans Hofschneider;
Detection of hepatitis B virus-specific DNA in the genomes of human hepatocellular carcinoma and liver cirrhosis tissues.
J. Gen. Virol. 57:95-102(1981)

PubMed=6288577; DOI=10.1002/ijc.2910300106
Daniela Simon, David P. Aden, Barbara B. Knowles;
Chromosomes of human hepatoma cell lines.
Int. J. Cancer 30:27-33(1982)

PubMed=6889516; DOI=10.1016/0277-5379(82)90010-4
Fred R. Sattler, Stephen Paolucci, John W. Kreider, Roger L. Ladda;
A human hepatoma cell line (PCL/PRF/5) produces lung metastases and secretes HBsAg in nude mice.
Eur. J. Cancer Clin. Oncol. 18:381-389(1982)

PubMed=6225510; DOI=10.1007/BF00199161; PMCID=PMC11039258
Aleta Keong, Arthur Ronald Rabson;
Supernatant derived from a human hepatocellular carcinoma cell line (PLC/PRF/5) activates a population of T-suppressor cells.
Cancer Immunol. Immunother. 15:178-182(1983)

PubMed=6302689; DOI=10.1073/pnas.80.9.2505; PMCID=PMC393854
Anne Dejean-Assemat, Christian Brechot, Pierre Tiollais, Simon Wain-Hobson;
Characterization of integrated hepatitis B viral DNA cloned from a human hepatoma and the hepatoma-derived cell line PLC/PRF/5.
Proc. Natl. Acad. Sci. U.S.A. 80:2505-2509(1983)

PubMed=6317496
Francis Barin, Alain Goudeau, Christian Brechot, Jean-Loup Romet-Lemonne, Camille Sureau, Gerard Lesage;
Further studies on production and characterization of HBsAg derived from a human hepatoma cell line (PLC/PRF/5).
Dev. Biol. Stand. 54:81-92(1983)

PubMed=6555060; DOI=10.1007/BF00199162; PMCID=PMC11039064
Aleta Keong, Jean Herman, Arthur Ronald Rabson;
Supernatant derived from a human hepatocellular carcinoma cell line (PLC/PRF/5) depresses natural killer (NK) cell activity.
Cancer Immunol. Immunother. 15:183-187(1983)

PubMed=2414854
Sanet Aspinall, Jennifer J. Alexander;
Hepatitis B virus gene expression in two cell lines, one derived from a natural human infection, the other experimentally infected in vitro.
S. Afr. Med. J. 68:751-754(1985)

PubMed=2992761; DOI=10.1016/0165-4608(85)90033-0
Maximina R. Pinto, Elke M. Bey, Rene Bernstein;
The PLC/PRF/5 human hepatoma cell line. I. Reevaluation of the karyotype.
Cancer Genet. Cytogenet. 18:11-18(1985)

PubMed=2992762; DOI=10.1016/0165-4608(85)90034-2
Anne M. Bowcock, Maximina R. Pinto, Elke M. Bey, Johannes M. Kuyl, Geoffrey Mark Dusheiko, Rene Bernstein;
The PLC/PRF/5 human hepatoma cell line. II. Chromosomal assignment of hepatitis B virus integration sites.
Cancer Genet. Cytogenet. 18:19-26(1985)

PubMed=3023526; DOI=10.1099/0022-1317-67-11-2315
Sanet Aspinall, Jennifer J. Alexander, Pieter Bos;
Comparative expression of hepatitis B virus antigens in several cell model systems.
J. Gen. Virol. 67:2315-2323(1986)

DOI=10.1007/978-4-431-68349-0_4
Jennifer J. Alexander;
Human hepatoma cell lines.
(In book chapter) Neoplasms of the liver; Okuda, Kunio & Ishak, Kamal George (eds.); pp.47-56; Springer; Tokyo; Japan (1987)

PubMed=2439335; DOI=10.1111/j.1432-1033.1987.tb11497.x
Claude Vincent, Marianne Marceau, Pascale Blangarin, Patrick Bouic, Jean-Jacques Madjar, Jean-Pierre Revillard;
Purification of alpha 1-microglobulin produced by human hepatoma cell lines. Biochemical characterization and comparison with alpha 1-microglobulin synthesized by human hepatocytes.
Eur. J. Biochem. 165:699-704(1987)

PubMed=3431441; DOI=10.1016/s0076-6879(87)51006-0
Gretchen J. Darlington;
Liver cell lines.
Methods Enzymol. 151:19-38(1987)

PubMed=2542205; DOI=10.1111/j.1349-7006.1989.tb02290.x; PMCID=PMC5917712
Hitoshi Tsuda, Setsuo Hirohashi, Yukio Shimosato, Yoshinori Ino, Teruhiko Yoshida, Masaaki Terada;
Low incidence of point mutation of c-Ki-ras and N-ras oncogenes in human hepatocellular carcinoma.
Jpn. J. Cancer Res. 80:196-199(1989)

PubMed=1661347; DOI=10.2302/kjm.40.139
Hidetsugu Saito, Toshio Morizane, Tetsu Watanabe, Tatehiro Kagawa, Shingo Miyaguchi, Naoki Kumagai, Kanji Tsuchimoto, Masaharu Tsuchiya;
Proto-oncogene expression in three human hepatoma cell lines, HCC-M, HCC-T and PLC/PRF/5.
Keio J. Med. 40:139-145(1991)

PubMed=1317878; DOI=10.1016/0166-0934(92)90047-h
Wilhelm Otto Karl Grabow, D.L. Puttergill, Albert Bosch;
Propagation of adenovirus types 40 and 41 in the PLC/PRF/5 primary liver carcinoma cell line.
J. Virol. Methods 37:201-207(1992)

PubMed=8224613; DOI=10.1096/fasebj.7.14.8224613
Alain Puisieux, Katherine Galvin, Frederic Troalen, Brigitte Bressac, Christophe Marcais, Eithan Galun, Frederique Ponchel, Cengiz Yakicier, Jing-Wei Ji, Mehmet Ozturk;
Retinoblastoma and p53 tumor suppressor genes in human hepatoma cell lines.
FASEB J. 7:1407-1413(1993)

PubMed=8389256; DOI=10.1093/carcin/14.5.987
Ih-Chang Hsu, Takayoshi Tokiwa, William P. Bennett, Robert A. Metcalf, Judith A. Welsh, Tsung-Tang Sun, Curtis Craig Harris;
p53 gene mutation and integrated hepatitis B viral DNA sequences in human liver cancer cell lines.
Carcinogenesis 14:987-992(1993)

PubMed=7874267; DOI=10.1007/BF02349278
Shigeo Ikuta, Fumio Itoh, Yuji Hinoda, Minoru Toyota, Yusuke Makiguchi, Kohzoh Imai, Akira Yachi;
Expression of cytoskeletal-associated protein tyrosine phosphatase PTPH1 mRNA in human hepatocellular carcinoma.
J. Gastroenterol. 29:727-732(1994)

PubMed=8050184; DOI=10.1111/j.1365-2249.1994.tb06089.x; PMCID=PMC1534706
Ahmed Abdulhay Wadee, Alan Paterson, Keren Anne Coplan, Selvan G. Reddy;
HLA expression in hepatocellular carcinoma cell lines.
Clin. Exp. Immunol. 97:328-333(1994)

PubMed=8835345; DOI=10.1002/(SICI)1096-9071(199602)48:2<133::AID-JMV3>3.0.CO;2-A
So Tsuboi, Seishi Nagamori, Masahiro Miyazaki, Koichiro Mihara, Ken-ichi Fukaya, Kiichiro Teruya, Tsunenori Kosaka, Takao Tsuji, Masayoshi Namba;
Persistence of hepatitis C virus RNA in established human hepatocellular carcinoma cell lines.
J. Med. Virol. 48:133-140(1996)

DOI=10.11418/jtca1981.16.3_173
Koichiro Mihara, Masahiro Miyazaki, Kazuo Fushimi, Toshiya Tsuji, Yusuke Inoue, Ken-ichi Fukaya, Ryuichiro Ohashi, Masayoshi Namba;
The p53 gene status and other cellular characteristics of human cell lines maintained in our laboratory.
Tissue Cult. Res. Commun. 16:173-178(1997)

PubMed=9023415; DOI=10.1006/cimm.1996.1062
Naoko Seki, Tomoaki Hoshino, Megumi Kikuchi, Akihiro Hayashi, Kyogo Itoh;
HLA-A locus-restricted and tumor-specific CTLs in tumor-infiltrating lymphocytes of patients with non-small cell lung cancer.
Cell. Immunol. 175:101-110(1997)

PubMed=9178645; DOI=10.1006/cimm.1997.1108
Masanobu Nakao, Michio Sata, Hideki Saitsu, Shigeru Yutani, Mayumi Kawamoto, Masamichi Kojiro, Kyogo Itoh;
CD4+ hepatic cancer-specific cytotoxic T lymphocytes in patients with hepatocellular carcinoma.
Cell. Immunol. 177:176-181(1997)

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Li-Qun Jia, Motonobu Osada, Chikashi Ishioka, Makio Gamo, Shuntaro Ikawa, Takao Suzuki, Hideki Shimodaira, Tomohito Niitani, Toshio Kudo, Mitoshi Akiyama, Narimiti Kimura ...Show all 18 authors... , Mitsuyoshi Matsuo, Hiroshi Mizusawa, Noriho Tanaka, Hideki Koyama, Masayoshi Namba, Ryunosuke Kanamaru, Toshio Kuroki; Show fewer authors
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

PubMed=9359923; DOI=10.18926/AMO/30789
Koichiro Mihara, Masahiro Miyazaki, Tadashi Kondo, Kazuo Fushimi, Toshiya Tsuji, Yusuke Inoue, Ken-ichi Fukaya, Chikashi Ishioka, Masayoshi Namba;
Yeast functional assay of the p53 gene status in human cell lines maintained in our laboratory.
Acta Med. Okayama 51:261-265(1997)

PubMed=10523694; DOI=10.3892/or.6.6.1267
Chong Gao, Ryuichiro Ohashi, Hong Pu, Yusuke Inoue, Toshiya Tsuji, Masahiro Miyazaki, Masayoshi Namba;
Yeast functional assay of the p53 gene status in 11 cell lines and 26 surgical specimens of human hepatocellular carcinoma.
Oncol. Rep. 6:1267-1271(1999)

PubMed=11050057; DOI=10.1053/jhep.2000.19349
Nathalie Wong, Paul Bo-San Lai, Elizabeth Pang, Thomas Wai-Tong Leung, Joseph Wan-Yee Lau, Philip James Johnson;
A comprehensive karyotypic study on human hepatocellular carcinoma by spectral karyotyping.
Hepatology 32:1060-1068(2000)

PubMed=12029633; DOI=10.1053/jhep.2002.33683
Kohichiroh Yasui, Shigeki Arii, Chen Zhao, Issei Imoto, Masakazu Ueda, Hisaki Nagai, Mitsuru Emi, Johji Inazawa;
TFDP1, CUL4A, and CDC16 identified as targets for amplification at 13q34 in hepatocellular carcinomas.
Hepatology 35:1476-1484(2002)

PubMed=15767549; DOI=10.1158/1535-7163.MCT-04-0234
Noriyuki Nakatsu, Yoko Yoshida, Kanami Yamazaki, Tomoki Nakamura, Shingo Dan, Yasuhisa Fukui, Takao Yamori;
Chemosensitivity profile of cancer cell lines and identification of genes determining chemosensitivity by an integrated bioinformatical approach using cDNA arrays.
Mol. Cancer Ther. 4:399-412(2005)

PubMed=20069059; DOI=10.1155/2010/437143; PMCID=PMC2801507
Chantragan Srisomsap, Phannee Sawangareetrakul, Pantipa Subhasitanont, Daranee Chokchaichamnankit, Khajeelak Chiablaem, Vajarabhongsa Bhudhisawasdi, Sopit Wongkham, Jisnuson Svasti;
Proteomic studies of cholangiocarcinoma and hepatocellular carcinoma cell secretomes.
J. Biomed. Biotechnol. 2010:437143.1-437143.18(2010)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=23505090; DOI=10.1002/hep.26402
Kai Wang, Ho Yeong Lim, Stephanie Shi, Jeeyun Lee, Shi-Bing Deng, Tao Xie, Zhou Zhu, Yu-Li Wang, David Pocalyko, Wei Jennifer Yang, Paul A. Rejto ...Show all 14 authors... , Mao Mao, Cheol-Keun Park, Jiang-Chun Xu; Show fewer authors
Genomic landscape of copy number aberrations enables the identification of oncogenic drivers in hepatocellular carcinoma.
Hepatology 58:706-717(2013)

PubMed=23887712; DOI=10.1038/ncomms3218; PMCID=PMC3731665
Jean-Charles Nault, Maxime Mallet, Camilla Pilati, Julien Calderaro, Paulette Bioulac-Sage, Christophe Laurent, Alexis Laurent, Daniel Cherqui, Charles Balabaud, Jessica Zucman-Rossi;
High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions.
Nat. Commun. 4:2218.1-2218.7(2013)

PubMed=25485619; DOI=10.1038/nbt.3080
Christiaan Klijn, Steffen Durinck, Eric W. Stawiski, Peter M. Haverty, Zhao-Shi Jiang, Han-Bin Liu, Jeremiah Degenhardt, Oleg Mayba, Florian Gnad, Jin-Feng Liu, Gregoire Pau ...Show all 30 authors... , Jens Reeder, Yi Cao, Kiran Mukhyala, Suresh K. Selvaraj, Ma-Mie Yu, Gregory J. Zynda, Matthew J. Brauer, Thomas D. Wu, Robert Clifford Gentleman, Gerard Manning, Robert L. Yauch, Richard Bourgon, David Stokoe, Zora Modrusan, Richard M. Neve, Frederic J. de Sauvage, Jeffrey Settleman, Somasekar Seshagiri, Ze-Min Zhang; Show fewer authors
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25574106; DOI=10.3748/wjg.v21.i1.311; PMCID=PMC4284350
Dilek Cevik, Gokhan Yildiz, Mehmet Ozturk;
Common telomerase reverse transcriptase promoter mutations in hepatocellular carcinomas from different geographical locations.
World J. Gastroenterol. 21:311-317(2015)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, A. Karina Eterovic, Lauren Averett Byers ...Show all 25 authors... , Michael A. Davies, Wan-Leng Deng, Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=29892436; DOI=10.1098/rsos.172472; PMCID=PMC5990783
Setsuko Shioda, Fumio Kasai, Ken Watanabe, Kohei Kawakami, Azusa Ohtani, Masashi Iemura, Midori Ozawa, Akemi Arakawa, Noriko Hirayama, Eiko Kawaguchi, Tomoko Tano ...Show all 15 authors... , Sayaka Miyata, Motonobu Satoh, Norio Shimizu, Arihiro Kohara; Show fewer authors
Screening for 15 pathogenic viruses in human cell lines registered at the JCRB Cell Bank: characterization of in vitro human cells by viral infection.
R. Soc. Open Sci. 5:172472-172472(2018)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31063779; DOI=10.1053/j.gastro.2019.05.001
Stefano Caruso, Anna-Line Calatayud, Jill Pilet, Tiziana La Bella, Samia Rekik, Sandrine Imbeaud, Eric Letouze, Lea Meunier, Quentin Bayard, Nataliya Rohr-Udilova, Camille Peneau ...Show all 20 authors... , Bettina Grasl-Kraupp, Leanne de Koning, Berengere Ouine, Paulette Bioulac-Sage, Gabrielle Couchy, Julien Calderaro, Jean-Charles Nault, Jessica Zucman-Rossi, Sandra Rebouissou; Show fewer authors
Analysis of liver cancer cell lines identifies agents with likely efficacy against hepatocellular carcinoma and markers of response.
Gastroenterology 157:760-776(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31378681; DOI=10.1016/j.ccell.2019.07.001; PMCID=PMC7505724
Zhi-Xin Qiu, Hong Li, Zheng-Tao Zhang, Zhen-Feng Zhu, Sheng He, Xu-Jun Wang, Peng-Cheng Wang, Jian-Jie Qin, Li-Ping Zhuang, Wei Wang, Fu-Bo Xie ...Show all 33 authors... , Ying Gu, Ke-Ke Zou, Chao Li, Chun Li, Chen-Hua Wang, Jin Cen, Xiao-Tao Chen, Ya-Jing Shu, Zhao Zhang, Lu-Lu Sun, Li-Hua Min, Yong Fu, Xiao-Wu Huang, Hui Lv, He Zhou, Yuan Ji, Zhi-Gang Zhang, Zhi-Qiang Meng, Xiao-Lei Shi, Hai-Bin Zhang, Yi-Xue Li, Li-Jian Hui; Show fewer authors
A pharmacogenomic landscape in human liver cancers.
Cancer Cell 36:179-193.e11(2019)

Cross-references
Cell line collections (Providers) ATCC; CRL-8024
BCRC; 60223
BCRJ; 0274
CLS; 300315
ECACC; 85061113
IZSLER; BS TCL 122
JCRB; IFO50069
JCRB; JCRB0406
KCB; KCB 200785YJ
KCLB; 28024
NCBI_Iran; C145
RCB; RCB1887 - Discontinued
TKG; TKG 0376
Ubigene; YC-C125
Cell line databases/resources CLO; CLO_0008458
CLO; CLO_0008459
MCCL; MCC:0000384
CLDB; cl3914
CLDB; cl3915
CLDB; cl3916
CLDB; cl5248
cancercelllines; CVCL_0485
CCRID; 1101HUM-PUMC000674
CCRID; 1102HUM-NIFDC00071
CCRID; 3101HUMTCHu119
CCRID; 4201HUM-CCTCC00644
Cell_Model_Passport; SIDM01318
CGH-DB; 9070-4
DepMap; ACH-001318
LIMORE; PLC8024
LIMORE; PLCPRF5
LINCS_LDP; LCL-1942
TOKU-E; 2898
Anatomy/cell type resources BTO; BTO_0003492
Biological sample resources BioSample; SAMN03471130
BioSample; SAMN03473236
BioSample; SAMN10988112
CRISP screens repositories BioGRID_ORCS_Cell_line; 484
Chemistry resources ChEMBL-Cells; CHEMBL3308140
ChEMBL-Targets; CHEMBL1075561
GDSC; 925349
PharmacoDB; PLCPRF5_1274_2019
PubChem_Cell_line; CVCL_0485
Encyclopedic resources Wikidata; Q54947574
Experimental variables resources EFO; EFO_0006291
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-2770
GEO; GSM207051
GEO; GSM565881
GEO; GSM827153
GEO; GSM886865
GEO; GSM887520
GEO; GSM887930
GEO; GSM888602
GEO; GSM936773
GEO; GSM2551580
GEO; GSM2551581
Polymorphism and mutation databases Cosmic; 721061
Cosmic; 808505
Cosmic; 871514
Cosmic; 873402
Cosmic; 925349
Cosmic; 945155
Cosmic; 948065
Cosmic; 1019318
Cosmic; 1351513
Cosmic; 1518224
Cosmic; 2023861
Cosmic; 2162538
Cosmic; 2321033
Cosmic; 2674231
Cosmic; 2773187
IARC_TP53; 107
IARC_TP53; 30016
LiGeA; CCLE_292
Progenetix; CVCL_0485
Sequence databases EGA; EGAS00001000610
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number47