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Cellosaurus (CVCL_XB37)

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Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: MD Anderson Cell Lines Project.
Part of: NCI RAS program mutant KRAS cell line panel.
Part of: RAS genetic alteration cell panel (ATCC TCP-1031).
From: Johns Hopkins University School of Medicine; Baltimore; USA.
Population: Caucasian.
Doubling time: 19.2 hours (PubMed=9612602); 30 hours (PubMed=25984343).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Metabolomics.
Omics: Phenotyping; CRISPR screening.
Omics: Phenotyping; Drug screening.
Omics: Phenotyping; shRNA library screening.
Omics: Proteomics.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Pancreas; UBERON=UBERON_0001264.
Sequence variations
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (PubMed=9612602; ATCC=CRL-2547; Cosmic-CLP=925348; DepMap=ACH-000060).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ile255Asn (c.764T>A); ClinVar=VCV000232289; Zygosity=Homozygous (Cosmic-CLP=925348; DepMap=ACH-000060).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.61
Native American1.14
East Asian, North0.96
East Asian, South0
South Asian0.11
European, North66.18
European, South31
Disease Pancreatic ductal adenocarcinoma (NCIt: C9120)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_3567 ! PL45
Sex of cell Male
Age at sampling 81Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-2547; CLS=300599; Cosmic-CLP=925348

Markers:
AmelogeninX
CSF1PO12
D2S133817,18
D3S135814
D5S81813
D6S104317
D7S8208,9
D8S117913,14
D12S39117,20
D13S31712
D16S5399,12
D18S5115
D19S43313,14
D21S1130
FGA20
Penta D12
Penta E11,13
TH016,9.3
TPOX11
vWA16

Run an STR similarity search on this cell line
Web pages Info; MCLP; -; https://tcpaportal.org/mclp/
Publications





Gerd Scherer;
A somatic cell hybrid panel for distal 17q: GDIA1 maps to 17q25.3.
Cytogenet. Cell Genet. 76:172-175(1997)




Cancer Chemother. Pharmacol. 43:198-204(1999)


Paula D. Bos, Xiang H.-F. Zhang, Cristina Nadal, Wei-Ping Shu, Roger R. Gomis, Don X. Nguyen, Andy J. Minn, Marc Joan van de Vijver, William Levi Gerald, John A. Foekens, Joan Massague;
Genes that mediate breast cancer metastasis to the brain.
Nature 459:1005-1009(2009)



Characterisation of a novel cell line (CSQT-2) with high metastatic activity derived from portal vein tumour thrombus of hepatocellular carcinoma.
Br. J. Cancer 102:1618-1626(2010)



switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K.
Cancer Cell 18:683-695(2010)


Julie Adam, Ann Hedley, Gabriela Kalna, Ian Philip Mark Tomlinson, Patrick John Pollard, David George Watson, Ralph J. DeBerardinis, Tomer Shlomi, Eytan Ruppin, Eyal Gottlieb;
Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase.
Nature 477:225-228(2011)


Warren Fiskus, Srdan Verstovsek, Taghi Manshouri, Rekha Rao, Ramesh Balusu, Sreedhar Venkannagari, Narasimharao Nalabothula, Kyungsoo Ha, Jacqueline E. Smith, Stacey L. Hembruff, Sunil Abhyankar ...Show all 13 authors... , Joseph Patrick McGuirk, Kapil N. Bhalla; Show fewer authors
Heat shock protein 90 inhibitor is synergistic with JAK2 inhibitor and overcomes resistance to JAK2-TKI in human myeloproliferative neoplasm cells.
Clin. Cancer Res. 17:7347-7358(2011)



electron-transfer/higher-energy collision dissociation (EThcD).
Proc. Natl. Acad. Sci. U.S.A. 111:4507-4512(2014)


Yasuhiro Takashima, Ge Guo, Remco Loos, Jennifer Nichols, Gabriella Ficz, Felix Krueger, David Oxley, Fatima Santos, James Clarke, William Mansfield, Wolf Reik ...Show all 13 authors... , Paul Bertone, Austin Gerard Smith; Show fewer authors
Resetting transcription factor control circuitry toward ground-state pluripotency in human.
Cell 158:1254-1269(2014)




Cancer Immunol. Immunother. 65:485-492(2016)


Thomas Graf;
Erratum to 'C/EBPalpha induces highly efficient macrophage transdifferentiation of B lymphoma and leukemia cell lines and impairs their tumorigenicity'.
Cell Rep. 19:1281-1281(2017)



literature.
Cancer Res. 77:2784-2788(2017)


Ruta Meleckyte, Yasin Memari, Nathalie Moens, Filipa Soares, Alice Mann, Ian Streeter, Chukwuma A. Agu, Alex Alderton, Rachel Nelson, Sarah Harper, Minal J. Patel ...Show all 27 authors... , Alistair White, Sharad R. Patel, Laura Clarke, Reena Halai, Christopher Michael Kirton, Anja Kolb-Kokocinski, Philip L. Beales, Ewan Birney, Davide Danovi, Angus Iain Lamond, Willem Hendrik Ouwehand, Ludovic Vallier, Fiona Mary Watt, Richard Michael Durbin, Oliver Stegle, Daniel J. Gaffney; Show fewer authors
Common genetic variation drives molecular heterogeneity in human iPSCs.
Nature 546:370-375(2017)


Tetsuhiro Kikuchi, Asuka Morizane, Daisuke Doi, Hiroaki Magotani, Hirotaka Onoe, Takuya Hayashi, Hiroshi Mizuma, Sayuki Takara, Ryosuke Takahashi, Haruhisa Inoue, Satoshi Morita ...Show all 16 authors... , Michio Yamamoto, Keisuke Okita, Masato Nakagawa, Malin Parmar, Jun Takahashi; Show fewer authors
Human iPS cell-derived dopaminergic neurons function in a primate Parkinson's disease model.
Nature 548:592-596(2017)




Cancer Cell 33:386-400.e5(2018)


Katsushi Tokunaga, Masao Nagasaki, Seiji Kito, Keiichi Isoyama, Masafumi Onodera, Hideo Kaneko, Naomichi Matsumoto, Fumihiko Matsuda, Keitaro Matsuo, Yoshiyuki Takahashi, Tomoji Mashimo ...Show all 13 authors... , Seiji Kojima, Tomoo Ogi; Show fewer authors
Digenic mutations in ALDH2 and ADH5 impair formaldehyde clearance and cause a multisystem disorder, AMeD syndrome.
Sci. Adv. 6:eabd7197.1-eabd7197.15(2020)

Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number43